ABSTRACT
Objective To study the clinical efficacy of compound herba Houttuyniae granules used in mycoplasma pneumonia in the elderly and analyze the change of IL-6,serum myocardial enzymes and vascular endothelial growth factor before and after the treatment.Methods According to treatment methods,80 elderly patients with mycoplasma pneumonia,were divided into the control group and treatment group,40 cases in each group,the control group were given Ribavirin granules,the treatment group was given on the basis of the control group and compound herba Houttuyniae granules.The therapeutic effects and the incidence of adverse drug reactions were observed,and the change of IL-6,serum myocardial enzymes and vascular endothelial growth factor of the two groups before and after the treatment were compared.Results After 7-days'treatment,the efficiency of the treatment group(97.5％) was significantly higher than that of the control group(72.5％) (x2 =9.804,P ＜0.05).After the drug treatment,the rate of adverse drug reactions was 5.0％ in the treatment group,which was significantly lower than the 32.5％ in the control group(x2 =9.928,P ＜ 0.05).Before treatment,the IL-6,serum myocardial enzymes and vascular endothelial growth factor were not significantly different between the two groups (all P ＞ 0.05).After treatment,the IL-6,serum myocardial enzymes and vascular endothelial growth factor of the treatment group were significantly lower than those of the control group (all P ＜ 0.05).Conclusion The treatment of compound herba Houttuyniae granules used in elderly mycoplasma pneumonia is efficient and the incidence of adverse reactions was low.It can improve the clinically relevant outcome measures and is worthy of clinical application.
ABSTRACT
Objective: To establish the method for quality control of Compound Herba Houttuyniae Granules(Herba Houttuyniae, Radix Scutellariae, Radix Isatidis, Flos Lonicerae, Fructus Forsythiae). Methods: Herba houttuyniae, Flos Lonicerae, Fructus Forsythiae in this medicine were identified by TLC. The content of baicalin in this medicine was determined by HPLC. Results: Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae could be identified by TLC. The content of baicalin determined by HPLC was 7.33～7.65 mg?g -1 . The average recovery was 99.16% and the RSD was 1.06%( n =6). Conclusion: The method was simple, accurate and with strong specificity and can be used for the quality control of Compound Herba Houttuyniae Granules.