ABSTRACT
Objective:To compare the efficacy and safety between ozonated oil and compound flumethasone ointment in the treatment of psoriasis vulgaris.Methods:A left/right self-controlled,parallel group study was conducted.Forty patients with stable psoriasis vulgaris were enrolled in the study,whose lesions were symmetrical and involvement areas were ＜30％ body surface.The patients were divided into 2 groups.Patients with left lesions served as a test group were treated daily for ozonated oil twice,and patients with right lesions served as a control group were treated daily for compound flumetasone ointment twice.The patients in the 2 groups were treated for 4 weeks.The clinical efficacy and safety were observed at 1,2 and 4 weeks after the treatment.Results:After 1 week treatment,the effective rates of the test group and the control group were 60.58％ and 72.28％,respectively,with significant difference between them (P＜0.05).At 2 weeks and 4 weeks after the treatment,the efficacy in the test group was similar to that in the control group.The effective rates in the test group and the control group were 69.84％ and 70.25％ after 2 weeks,respectively,70.88％ and 71.23％ after 4 weeks,respectively.There was no significant difference between the 2 groups (P＜0.05).In addition,the reflectance confocal microscope results in both the test group and the control group after 4 weeks showed that the epidermis was approximately normal.There were few inflammatory cells infiltration in the dermal papilla,and the inflammatory cells infiltration was significantly reduced after treatment.Conclusion:Ozonated oil treatment for stable psoriasis is safe and effective,and its efficacy is equivalent to the effect ofglucocorticoid topical preparations.
ABSTRACT
Objective Psoriasis vulgaris (PV) is easy to prone to recur and hard to cure and little research has been done on combined treatment on PV.The article was to study the clinical effects of total glucosides of paeony capsules (TGP) combined with acitretin and compound flumethasone on PV as well as the peripheral blood cytokine levels.Methods 126 patients with PV who visited our hospital from October 2015 to January 2017 were randomly divided into combined treatment group (63 cases) and control group (63 cases).Both groups were treated with oral acitretin and topical compound flumethasone, what's more, the compound flumethasone group received oral TGP treatment, 8 weeks for a course.The clinical therapeutic effects were evaluated by the levels of peripheral blood IL-17, IL-18, IL-23, TNF-α level, PASI score and percentage of total skin lesions before and after the treatment.Results After the treatment, the concentration of IL-17, IL-18, IL-23 significantly decreased(P<0.05), which was significantly less in combined treatment group compared with control group (IL-17 [61.18±8.91] vs [78.64±7.85], IL-18 [68.56±17.95] vs [79.49±18.64], IL-23 [70.13±12.16] vs [91.18±16.89] pg/ML)(P<0.05).Moreover, the TNF-α level, the PASI score and the percentage of total skin lesions significantly decreased in both groups after treatment(P<0.05), which was significantly less in combined treatment group compared with control group (TNF-α level [14.47±7.53] vs [23.49±8.12]ng/L, PASI score [4.09±1.29] vs [7.29±5.13], the percentage of total skin lesions [6.17±4.59]% vs [8.09±5.18]%) (P<0.05).Conclusion TGP combined with acitretin and compound flumethasone can significantly enhance the clinical therapeutic effects and effectively regulate the levels of the IL-17, IL-18, IL-23 and TNF-α level, which results in treating psoriasis vulgaris.