ABSTRACT
Objective: To optimize the optional extraction process parameters of Modified Simiao Granule (MSG). Methods: HPLC was employed to determine the content of rhodoglycoside, chlorogenic acid, ammonium glycyrrhizate, berberine hydrochloride, and glycyrrhizin, using the extraction ratio, dried cream yield, and fingerprint similarity of which as comprehensive evaluation indexes, orthogonal test was used to investigate effects of solid-liquid ratio, extraction time and times on extraction process. Information entropy method was used to determine the objective weight of each index to achieve orthogonal test optimization of extraction process. Results: According to the result of comprehensive score, the optimal extraction conditions of this preparation were as follows: extracted twice with 10 times of water quantity, each for 30 min. The mean of the three batches of comprehensive evaluation was 88.91 and the RSD value was 0.61%. Conclusion: The optimized technologies are stable, repeatable, feasible and suitable for the industrial production of MSG.