Prediction of Drug–Drug Interactions by Using Profile Fingerprint Vectors and Protein Similarities / 대한의료정보학회지

Advances in determination of median sagittal plane of facial soft tissue / 中华口腔医学杂志

Facial symmetry is a crucial component of human facial esthetics. Along with the increasing pursuit of aesthetic, in recent years, more and more researchers have focused on facial asymmetry assessment, of which determining the facial median sagittal plane is the first and most important step, and it will directly affect the accuracy of asymmetry evaluation and clinical treatment outcome. Limited by technical means, the earlier studies of facial soft tissue asymmetry assessment were mainly based on midline from two-dimensional (2D) images. Along with the development of three-dimensional (3D) measurement and data analysis techniques, new methods such as 3D landmark-based method and mirror-original alignment method have become main trend nowadays. This article systematically reviews the methods of determination of median sagittal plane of facial soft tissue, elaborates the developments and the latest research progress in this field, and discusses the advantages and limitations of each method in order to provide reference for clinical application.

Detección de comunidades a partir de redes de coautoría en grafos RDF / Community detection using co-authorship networks in RDF graphs / Detecção de comunidades a partir de redes de coautoria em grafos RDF

La detección de comunidades se refiere al problema de identificar comunidades o particiones de nodos que comparten propiedades comunes en una red. Las redes de coautoría se consideran redes complejas, donde los nodos de la red son los autores, y los enlaces entre los nodos establecen la relación de coautoría en una o varias publicaciones. En los últimos años se han desarrollado investigaciones con el objetivo de publicar metadatos bibliográficos siguiendo los principios de los datos enlazados. Como resultado se obtienen grafos RDF que contienen los autores y las relaciones de coautoría que se establecen entre ellos. En este artículo se propone un método para la detección y visualización de comunidades en grafos RDF teniendo en cuenta las relaciones de coautoría como indicador para medir la colaboración científica. Con la implementación del método se pretende dotar a los especialistas en ciencias de la información de una herramienta de análisis que ayude en el proceso de toma de decisiones y la realización de estudios en esta área.

Community detection refers to the problem to identify communities or partitions of nodes that shares common properties in a network. The co-authorship networks are considered complex networks, where the nodes of the network are authors and the edges between nodes provides the co-authorship relationships in one or more publications. In recent years, researches have been carried out with the aim to publish bibliographic metadata following the principles of the linked data. Resulting from this, RDF graphs are obtained, containing the authors and the co-authorship relationships among them. In this paper we propose a method for detecting and visualizing communities in RDF graphs, considering co-authorship relationships as an indicator to measure scientific collaboration. With the implementation of the method proposed, we provide an analysis tool for specialists in information sciences, which improve the process of decision making and implementation of studies in the area.

A detecção de comunidades refere-se ao problema de identificar comunidades o partições de nodos que partilham propriedades comuns em uma rede. As redes de coautoria são consideradas redes complexas, onde os nodos da rede são os autores, e os enlaces entre os nodos estabelecem a relação de coautoria em uma ou várias publicações. Nos últimos anos se têm desenvolto investigações com o objetivo de publicar metadados bibliográficos seguindo os princípios dos dados ligados. Como resultado se obtêm grafos RDF que contêm os autores e as relações de coautoria que se estabelecem entre eles. Neste artigo se propõe um método para a detecção e visualização de comunidades em grafos RDF tendo em conta as relações de coautoria como indicador para medir a colaboração científica. Com a implementação do método se pretende dotar aos especialistas em ciências da informação de uma ferramenta de análise que ajude no processo de toma de decissões e a realização de estudos nesta área.

Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews / 예방의학회지

OBJECTIVES: The systematic review (SR) is a research methodology that aims to synthesize related evidence. Updating previously conducted SRs is necessary when new evidence has been produced, but no consensus has yet emerged on the appropriate update methodology. The authors have developed a new SR update method called 'adaptive meta-analysis' (AMA) using the 'cited by', 'similar articles', and 'related articles' citation discovery tools in the PubMed and Scopus databases. This study evaluates the usefulness of these citation discovery tools for updating SRs. METHODS: Lists were constructed by applying the citation discovery tools in the two databases to the articles analyzed by a published SR. The degree of overlap between the lists and distribution of excluded results were evaluated. RESULTS: The articles ultimately selected for the SR update meta-analysis were found in the lists obtained from the 'cited by' and 'similar' tools in PubMed. Most of the selected articles appeared in both the 'cited by' lists in Scopus and PubMed. The Scopus 'related' tool did not identify the appropriate articles. CONCLUSIONS: The AMA, which involves using both citation discovery tools in PubMed, and optionally, the 'related' tool in Scopus, was found to be useful for updating an SR.

Compresión de imágenes médicas / Medical image compression: a review

La medicina moderna es una actividad cada vez más compleja, basada en la información proveniente de múltiples fuentes: historias clínicas, dictáfonos e imágenes y vídeos provenientes de múltiples dispositivos. Las imágenes médicas constituyen una de las fuentes de mayor importancia, por cuanto ofrecen un apoyo integral del acto médico: el diagnóstico y el seguimiento. Sin embargo, la cantidad de información generada por los dispositivos de adquisición de imágenes sobrepasa rápidamente la disponibilidad de almacenamiento que tienen los servicios de radiología, lo cual genera costos adicionales en equipos de cómputo con mayor capacidad de almacenamiento. Además, la tendencia actual de desarrollo de aplicaciones en la "nube de cómputo", tiene limitaciones por cuanto, aunque el almacenamiento es virtual y está disponible desde cualquier sitio, la conexión se hace a través de internet. En estos dos casos, el uso óptimo de la información requiere necesariamente de algoritmos de compresión potentes y adaptados a las necesidades de la actividad médica. En este artículo se presenta una revisión de las técnicas de compresión más utilizadas para el almacenamiento de imágenes, así como un análisis crítico de éstas desde el punto de vista de su uso en ambientes clínicos.

Modern medicine is an increasingly complex activity , based on the evidence ; it consists of information from multiple sources : medical record text , sound recordings , images and videos generated by a large number of devices . Medical imaging is one of the most important sources of information since they offer comprehensive support of medical procedures for diagnosis and follow-up . However , the amount of information generated by image capturing gadgets quickly exceeds storage availability in radiology services , generating additional costs in devices with greater storage capacity . Besides , the current trend of developing applications in cloud computing has limitations, even though virtual storage is available from anywhere, connections are made through internet . In these scenarios the optimal use of information necessarily requires powerful compression algorithms adapted to medical activity needs . In this paper we present a review of compression techniques used for image storage , and a critical analysis of them from the point of view of their use in clinical settings.

Archetype Model-Driven Development Framework for EHR Web System / 대한의료정보학회지

OBJECTIVES: This article describes the Web application framework for Electronic Health Records (EHRs) we have developed to reduce construction costs for EHR sytems. METHODS: The openEHR project has developed clinical model driven architecture for future-proof interoperable EHR systems. This project provides the specifications to standardize clinical domain model implementations, upon which the ISO/CEN 13606 standards are based. The reference implementation has been formally described in Eiffel. Moreover C# and Java implementations have been developed as reference. While scripting languages had been more popular because of their higher efficiency and faster development in recent years, they had not been involved in the openEHR implementations. From 2007, we have used the Ruby language and Ruby on Rails (RoR) as an agile development platform to implement EHR systems, which is in conformity with the openEHR specifications. RESULTS: We implemented almost all of the specifications, the Archetype Definition Language parser, and RoR scaffold generator from archetype. Although some problems have emerged, most of them have been resolved. CONCLUSIONS: We have provided an agile EHR Web framework, which can build up Web systems from archetype models using RoR. The feasibility of the archetype model to provide semantic interoperability of EHRs has been demonstrated and we have verified that that it is suitable for the construction of EHR systems.

Revisão de literatura: Implantação de Prontuário Eletrônico do Paciente / Literature review: Implementation of Electronic Patient / Revisión de la literatura: Aplicación de la Clínica Electrónica

Estudo de revisão identificando na literatura evidencia sobre a implantação de Prontuário Eletrônico de Paciente. Utilizou-se a Biblioteca Virtual de Saúde, base de dados LILACS, PUBMED, MEDLINE, as bibliotecas eletrônicas SciELO e SBIS. Os descritores "Prontuário eletrônico", "Computação de alto desempenho", "Informática médica" e "Sistemas de informação multi-hospitalar". Foram incluídos artigos publicados entre 2005 e 2011, nos idiomas português, inglês e espanhol e disponível na íntegra. Foram identificados 68 artigos. Após a exclusão das publicações que não correspondiam os critérios de seleção obtivemos 21 artigos. Resultados e Discussão: No ano de 2010 houve maior número de publicações (24%), seguido pelos anos 2006 (19%), 2009 e 2011 (14%). Os artigos foram analisados e agrupados nas áreas: Conceitos Gerais (29%), Evolução Histórica (19%), Escolha e desenvolvimento de software (14%) e Análise de desempenho (10%). Conclusões: O sucesso ou fracasso estão intimamente ligados ao envolvimento dos usuários no planejamento e diversas fases de implantação. Chama atenção também a preocupação que o uso da informática não deve eliminar o contato com o paciente.

Study of revision to identify the available evidences in literature on the Electronic Handbook implantation of patient in the years of 2005 - 2011. It was used Virtual Library of Health, database LILACS, PUBMED, MEDLINE, SciELO and SIBS. The used describers had been "electronic Handbook", "Computation of high performance", "Computer science measured", "Systems of multi-hospital information" and "use of the scientific information in the taking of decisions in health". Results and Quarrel: In the year of 2010 it had greater publication number (24%), followed per years 2006 (19%), 2009 and 2011 (14%). The articles had been analyzed and grouped in the areas: General concepts (29%), Historical Evolution (19%), Choice and development of software (14%) and Analysis of performance (10%). Conclusions: The success or failure is closely on to the envolvement of the users in the planning and diverse phases of implantation. Flame attention also the concern that the use of computer science does not have to eliminate the contact with the patient.

Estudio de la revisión para identificar las evidencias disponibles en literatura en la implantación electrónica del manual del paciente en los años de 2005 - 2011. Era biblioteca virtual usada de la salud, de las LILAS de la base de datos, de PUBMED, de MEDLINE, de SciELO y de SIBS. Los describers usados habían sido "manual electrónico", "cómputo del alto rendimiento", "informática medida", "sistemas de la información del multi-hospital" y "uso de la información científica en tomar de decisiones en salud". Resultados y pelea: En el año de 2010 hizo el mayor número de la publicación (el 24%), seguir por los años 2006 (el 19%), 2009 y 2011 (el 14%). Los artículos habían sido analizados y agrupados en las áreas: Conceptos generales (el 29%), evolución histórica (el 19%), opción y desarrollo del software (el 14%) y análisis del funcionamiento (el 10%). Conclusiones: El éxito o la falta está de cerca encendido al envolvement de los usuarios en el planeamiento y las fases diversas de la implantación. Flamee la atención también la preocupación que el uso de la informática no tiene que eliminar el contacto con el paciente.

Análise por meio do método dos elementos finitos de um protetor bucal para atividades esportivas / Finite elements analisis in mouthguard for sports ativities

O uso de protetores bucais na prática de esportes tem ampliado espaço no contexto da prevenção de traumas bucais, bem como apresentado melhoria no desempenho ao longo de sua história. O objetivo deste trabalho foi avaliar o comportamento do complexo bucodentoalveolar por meio do método dos elementos finitos. O estudo partiu de um modelo em formato esterolitográfico oriundo de uma tomografia computadorizada, o qual foi convertido para um modelo 3D pelo programa Rhinoceros® versão 4.0, sem protetor bucal (controle) e com protetor bucal de 4,0 mm de espessura em EVA (copolímero de etileno e acetato de vinila), os quais receberam duas cargas diferentes (500, 1000 N) no programa ANSYS® v.12 em regime quase estático e de caráter elástico linear. Pudemos observar que houve um padrão de comportamento das estruturas envolvidas quanto à dissipação das tensões geradas e ao se comparar o modelo controle com o modelo provido de protetor bucal houve uma absorção das tensões geradas em até 50%, permitindo confirmar a ação do protetor bucal em literatura e tornando o seu uso imperativo durante a prática de esportes, em especial as modalidades de maior contato.

The use of mouthguards in the practice of sports has expanded space in the prevention of oral trauma, and has presented performance improvement over its history. The aim of this study was to evaluate the behavior of complex dento alveolar buccal through the finite element method. The study was based on a template stereolitographic format come from a CT scan, which was converted to a 3D model by the program Rhinoceros® version 4.0, without a mouthguard (control) and mouthguard 4.0 mm thick copolymer of ethylene and vinyl acetate (EVA), which received two different loads (500, 1000 N) in ANSYS® v.12 under quasi-static linear and elastic character. We noticed that there was a pattern of behavior of the structures involved about the dissipation of tensions generated, and when the model was compared with the control model fitted with a mouthguard there was an absortion of the stresses generated in up to 50%, allowing to confirm the action of the mouthguard in literature and making its use mandatory for the practice of sports, especially the arrangements for closer contact.

Aplicação das tecnologias digitais virtuais no contexto psicopedagógico / The application of virtual digital technologies in the psychopedagogical context

As Tecnologias Digitais Virtuais (TDVs) trazem novas possibilidades de interação, comunicação e representação, possibilitando um leque cada vez maior de aplicações no campo psicopedagógico, pois podem tornar-se instrumentos para a investigação das vinculações inadequadas que ocorrem no processo de aprendizagem. No entanto, para o psicopedagogo ser o protagonista desse processo e atender à demanda da geração digital, é necessário vivenciar experiências com tais tecnologias, a fim de desenvolver competências didático-pedagógicas, aliadas a competências tecnológicas-digitais, que lhe viabilizem interagir e utilizar essas tecnologias em sua prática psicopedagógica, tanto institucional como clínica. Nesse contexto, apresentamos uma revisão teórica acerca das possibilidades psicopedagógicas do uso das TDVs, destacando contribuições advindas dos estudos e da experiência docente e psicopedagógica das autoras com a utilização dessas tecnologias. A partir das reflexões realizadas, acreditamos que a utilização das TDVs na prática psicopedagógica, por atuar no campo das representações virtuais, aciona os mecanismos da projeção, facilitando assim a investigação das significações do ato de aprender e a representação social que o sujeito faz dos conhecimentos escolares, familiares e consigo mesmo, abrindo novas vias para a ressignificação da aprendizagem...

Virtual Digital Technologies (VDTs) bring new possibilities of interaction, communication and representation, enabling a wider range of applications in the psychopedagogical field, as they can become instruments for the investigation of the inadequate connections that occur in the learning process. However, for psychopedagogists to be protagonists in this process and attend to the demand of the digital generation, it is necessary to have experience with such technologies, in order to develop didactic-pedagogical competences, allied with technological-digital competences, which enable the interaction and use of these technologies in their psychopedagogical practice, institutional as well as clinical. In this context, we present a theoretical review on the psychopedagogical possibilities for using VDTs, highlighting contributions from the studies and teaching and psychopedagogical experiences of the authors in using these technologies. Based on these reflections, we believe that the use of VDTs in the psychopedagogical practice, due to their working in the field of virtual representations, activate the projection mechanisms, thus facilitating the investigation of meanings in the act of learning and the social representation that the subject makes of academic and informal knowledge and of himself, opening new paths for new meanings of learning...

Stress distribution in the cervical region of an upper central incisor in a 3D finite element model

The aim of this study was to evaluate the stress distribution in the cervical region of a sound upper central incisor in two clinical situations, standard and maximum masticatory forces, by means of a 3D model with the highest possible level of fidelity to the anatomic dimensions. Two models with 331,887 linear tetrahedral elements that represent a sound upper central incisor with periodontal ligament, cortical and trabecular bones were loaded at 45º in relation to the tooth's long axis. All structures were considered to be homogeneous and isotropic, with the exception of the enamel (anisotropic). A standard masticatory force (100 N) was simulated on one of the models, while on the other one a maximum masticatory force was simulated (235.9 N). The software used were: PATRAN for pre- and post-processing and Nastran for processing. In the cementoenamel junction area, tensile forces reached 14.7 MPa in the 100 N model, and 40.2 MPa in the 235.9 N model, exceeding the enamel's tensile strength (16.7 MPa). The fact that the stress concentration in the amelodentinal junction exceeded the enamel's tensile strength under simulated conditions of maximum masticatory force suggests the possibility of the occurrence of non-carious cervical lesions such as abfractions.

EpiDoc®: plataforma de comunicação em epidemiologia / EpiDoc®: a communication platform in epidemiology

Introdução: EpiDoc® é um modelo para transferência de conhecimento na área de metodologia da pesquisa. Está baseado no conceito de estratégias de colaboração para a aprendizagem (learning communities ou communities of practice) mediante a união de esforços entre os interesses comuns de um grupo de profissionais. O objetivo deste projeto é desenvolver uma plataforma de comunicação para a transferência de conhecimento e desenvolvimento de competências em uma comunidade de prática de metodologia da pesquisa em saúde. Métodos:. A plataforma de comunicação está desenvolvido com a tecnologia de páginas de servidor ASP (Active Server Pages), interagindo com uma base de dados Microsoft SQL Server 2000. Na fase da avaliação, tomou-se uma amostra de 38 pessoas para responder a pesquisa de opinião de 84 perguntas que inclui as diferentes áreas a avaliar como são os conteúdos, a tecnologia, o ambiente educativo, os problemas e dificuldades, assim como os elementos positivos do processo de aprendizagem. Resultados: A plataforma divide-se basicamente em 2 zonas, uma pública e outra privada, e pode ser observado em inglês, espanhol e português. A plataforma conta com os seguintes módulos: Controle de acesso; biblioteca; administração de cursos; apresentações; assinatura de usuários para distribuição eletrônica de materiais educativos; correio eletrônico e correio massivo; salas virtuais de Chat; foros de discussão; manipulação de documentos entre tutores e usuários; aplicação de provas de avaliação para os usuários; geração automática de certificados; métricas e relatórios de atividades. A avaliação foi feita com uma amostra de 38 estudantes de um curso de Epidemiologia Clínica. O 94 % dos estudantes ficaram satisfeitos ou muito satisfeitos com a experiência de aprendizagem. O 95% considerou que tinha adquirido novas habilidades de comunicação e colaboração ao estudar por meio virtual. Para o 76% facilitou-se o trabalho em equipe, assim como para o 84% melhorou...

Introduction: Epidoc® is a model for the transference of knowledge in the field or research methodology. It is based on the concept of collaboration strategies for learning (learning communities or communities of practice) by the joint effort among common interests of a professional group. The objective of this project is to develop a communication platform for the knowledge transference and developing of competences in a community which practices the Research Methodology in the health field. Methods: The communication platform was designed with a technology of ASP (Active Server Pages) interacting with a Microsoft SQL Server 2000 data base. For the evaluation phase a sample of 38 people was taken to answer an opinion questionnaire of 84 questions which include the different areas to evaluate such as the contents, the technology, the learning environment, the problems and the difficulties and also all the positive elements of the learning process. Results: The communication platform is divided in two zones, one public and one private and is available in three different languajes: English, Spanish and Portuguese. The platform contains the following modules: access control; library; courses administration; presentations; subscriptions for electronic distribution of educational materials; electronic and massive mail; Chat virtual rooms; discussion forums; documents management between users and mentors; implementation of evaluation test for the users; generation of certificates; metrics and activities reports. The evaluation was implemented with a sample of 38 students from a Clinical Epidemiology course. 94% of the students were satisfied or very satisfied by the learning experience. 95% considered that they had acquired new communication and collaboration abilities at studying by the virtual way. For 76% the group work was eased as for 84% noticed an improve capacity to learn form the others, interacting among others...

Effective Query Expansion using Condensed UMLS Metathesaurus for Medical Information Retrieval / 대한의료정보학회지

Medical vocabularies in medical records are used in several synonyms and various expressions even though they are same concepts. Query expansion using a thesaurus enhances recall of medical information retrieval (IR) system for searching patient records or literatures. This study proposed IR system architecture applied the Metathesaurus of Unified Medical Language System (UMLS). To enhance the retrieval effectiveness at the same time to reduce retrieval time, we reconstructed condensed Metathesaurus (CMT), which is constituted of frequently used terms in medical records. We used 40,000 radiology reports of Brain CT/MRI at Seoul National University Hospital. The retrieval model we used is the Boolean methods. The results showed 15~27% effectiveness for searching relevant documents implementing the UMLS MT into IR system for query expansion. But it took 3.5 times longer for retrieval compared with non-MT implemented IR system. When we applied the CMT into IR system, however, the retrieval time reduced by 50% and the retrieval performance decreased only 8.7% compared with all MT implemented IR system. In this paper, we developed the medical document retrieval system applied UMLS MT for query expansion methods that can improve the relevant document retrieval performance, at the same time it can reduce the retrieval time through consisting condensed Metathesaurus for a specific domain.