ABSTRACT
Congenital peribronchial myofibroblastic tumor (CPMT) is a benign pulmonary spindle cell neoplasm of intrauterine and perinatal period, which is thought to arise from primitive peribronchial mesenchyme. We present a case detected incidentally in a one-month-old infant. The solid and partially necrotic tumor involved the right middle and lower lobes of the lung with extension to the diaphragm. Histologically, the tumor was composed of fasciculated monotonous spindle cells, proliferating peribronchiolar cartilage and round cells with rich vasculature, and high mitotic activity was identified in the round cell area. Immunohistochemical and electron microscopic studies showed that the spindle cells were myofibroblastic in phenotype. Although the tumor showed several malignant pathological features, recurrence was not observed in the two-year follow-up period, consistent with the benign clinical behavior of CPMT.
Subject(s)
Humans , Infant , Cartilage , Diaphragm , Electrons , Follow-Up Studies , Lung , Mesoderm , Myofibroblasts , Phenotype , RecurrenceABSTRACT
The epidermoid cyst is formed as the result of inclusion of epithelial elements at the time of closure of the neural tube. The incidence of this tumor is less than 3% of all spinal canal tumors in children, The authors have experienced a 6-year old child with intraspinal epidermoid cyst which presented with symptom of back and abdominal pain. The magnetic resonance imaging study showed intraspinal mass lesion from level of T12 to S1. The patient had no history of previous lumbar puncture. We have removed totally the pearly-like intradural mass with laminoplastic laminotomy from T12 to L5. The pathological findings were compatible with epidermoid cyst. The postoperative course was uneventful without any neurologic deficit. Characteristics of this lesion with a pertinent literature is reviewed.
Subject(s)
Child , Humans , Abdominal Pain , Epidermal Cyst , Incidence , Laminectomy , Magnetic Resonance Imaging , Neural Tube , Neurologic Manifestations , Spinal Canal , Spinal PunctureABSTRACT
A congenital salivary gland tumor, sialoblastoma, is extremely rare. A sialoblastoma of the parotid gland, occurring in a 28-week old fetus, is described. The histologic, immunohistochemical, and ultrastructural features of this tumor were studied. The tumor was characterized by solid nests or sheets of tumor cells intermingled with ductal structures lined by a columnar cells. Some of the tumor cells showed squamous differentiation. Immunohistochemically, these epidermoid cells reacted positively with anti-cytokeratin. But anti-S-100, anti- vimentin, anti-smooth muscle actin, anti-GFAP positive cells were not found. The ultrastructure was characterized by primitive epithelial cells. Although various names have been proposed, we favored the term "sialoblastoma". The histogenesis of this tumor is also discussed.
Subject(s)
Actins , Epithelial Cells , Fetus , Parotid Gland , Salivary Glands , VimentinABSTRACT
A suprasellar meningioma with multiple intratumoral cysts in a 6-month-old boy is reported. A review of literature disclosed only 11 cases so far. They showed a characteristic predominance in males and predominance of fibroblastic type on pathological examination. Intratumoral cystes are less common than peritumoral cysts. The various hypothesis regarding cyst formation are discussed.
Subject(s)
Humans , Infant , Male , Cysts/diagnosis , Meningeal Neoplasms/diagnosis , Meningioma/diagnosisABSTRACT
Herein reported is a case of congenital malignant melanoma in a premature male baby from a 25-year-old healthy mother who was found to have hydramnios at the 29th week of gestation. The pregnancy was interrupted because of a large posterior neck mass detected by ultrasonography. The large neck mass of the baby was a malignant melanoma involving deep dermis and subcutaneous tissue. The skin over the mass showed a large area of pigmentation with hairs and the pigmentation involved the occipital scalp and posterior neck. Microscopically, the tumor cells were monotonous and showed polygonal and epithelioid appearance with prominent nucleoli indicative of malignant melanoma of a minimal deviation variety. Neither junctional components nor benign dermal nevus cells were noted. There were no distant metastasis or underlying leptomeningeal melanosis. This tumor is presumed to have developed from either preexisted congenital giant pigmented nevus with loss of benign components or de novo origin.
Subject(s)
Adult , Female , Humans , Infant, Newborn , Male , Pregnancy , Abortion, Induced , Head and Neck Neoplasms/complications , Melanoma/congenital , PolyhydramniosABSTRACT
Epidermoid cyst is a congenital tumor and it's incidence is relatively rare in all intracranial tumors. Preference site is the basal surface of the brain, particularly the cerebellopontine angle and parasellar region. We report a epidermoid cyst in the fourth ventricle of 37 years old femals with signs of cerebellar dysfunctions. The literature on the incidence, diagnosis, surgical technoque and complications are reviewed.
Subject(s)
Adult , Humans , Brain , Cerebellar Diseases , Cerebellopontine Angle , Diagnosis , Epidermal Cyst , Fourth Ventricle , IncidenceABSTRACT
Dermoid and epidermoid of the spinal cord are rare and their percentage was 2.6% of spinal cord tumors. In dermoid average age of occurrence is 28.3 years. They are dysembryonic malformations. Dermoid consists of desquamated material, sebaceous material and hairs. The region of preference is lumbosacral spinal cords, especially cauda equina and conus medullaris. We are reporting a case of dermoid which has taken intracapsular enucleation and discuss about the epidemiology and pathogenesis.