ABSTRACT
BACKGROUND: Papular elastorrhexis (PE), eruptive collagenoma (EC), and nevus anelasticus (NA) are described as multiple small papules with decrease, fragmentation, or lack of dermal elastic fibers. These diseases are suggested to be the same entity. The change of collagen fibers in the conditions has not been addressed to date. OBJECTIVE: We compared the clinical features of the 3 diseases and investigated changes in the collagen fibers involved. METHODS: Twenty-four cases of PE, 12 cases of EC, and 2 cases of NA found in PubMed and the Korean database were reviewed. Changes in dermal collagen fibers in 10 cases with histological figures were investigated. RESULTS: There were significant similarities between the 3 entities in terms of their clinical features. Four patients with PE and 2 with EC with fine, dense collagen fibers were women who had multiple white to hypopigmented, slightly indurated to firm, millimeter-size papules on the trunk and/or extremities that progressed gradually after developing in the patients' first to third decades. CONCLUSION: The 3 conditions are the same clinical entity in our opinion; such cases with fine, dense collagen manifest typical features.
Subject(s)
Female , Humans , Collagen , Elastic Tissue , Extremities , NevusABSTRACT
BACKGROUND: Papular elastorrhexis (PE), eruptive collagenoma (EC), and nevus anelasticus (NA) are described as multiple small papules with decrease, fragmentation, or lack of dermal elastic fibers. These diseases are suggested to be the same entity. The change of collagen fibers in the conditions has not been addressed to date. OBJECTIVE: We compared the clinical features of the 3 diseases and investigated changes in the collagen fibers involved. METHODS: Twenty-four cases of PE, 12 cases of EC, and 2 cases of NA found in PubMed and the Korean database were reviewed. Changes in dermal collagen fibers in 10 cases with histological figures were investigated. RESULTS: There were significant similarities between the 3 entities in terms of their clinical features. Four patients with PE and 2 with EC with fine, dense collagen fibers were women who had multiple white to hypopigmented, slightly indurated to firm, millimeter-size papules on the trunk and/or extremities that progressed gradually after developing in the patients' first to third decades. CONCLUSION: The 3 conditions are the same clinical entity in our opinion; such cases with fine, dense collagen manifest typical features.
Subject(s)
Female , Humans , Collagen , Elastic Tissue , Extremities , NevusABSTRACT
Proteus syndrome is one of the very rare syndromes with occurrence of cerebriform connective tissue nevus. The aim of the present manuscript was to present a case of Proteus syndrome in an unusual facial location, which to the best of our knowledge, is being reported for the first time. The unusual occurrence further strengthens the mosaical basis of its etiopathogenesis.
Subject(s)
Adolescent , Facial Paralysis/etiology , Female , Nevus/pathology , Proteus Syndrome/complications , Proteus Syndrome/diagnosisABSTRACT
Mucinous nevus is a rare entity classified as either cutaneous mucinosis or connective tissue nevi. Clinically, grouped papules or plaques grow to form a verrucous or nevoid feature usually on the trunk. It can be present since birth or early childhood. Histologically, it consists of mucin deposits localized in the superficial dermis with or without epidermal changes. An 18-year-old boy presented with asymptomatic multiple grouped brown papules and coalescent plaques on his lower back that had been present since birth. Histological examination showed a band-like mucin deposit in the papillary dermis. To our knowledge, there have been only few reports of mucinous nevus in the literature. Here, we report a case of mucinous nevus present since birth, including a review of relevant literature.
Subject(s)
Adolescent , Humans , Male , Connective Tissue , Dermis , Mucinoses , Mucins , Nevus , ParturitionABSTRACT
BACKGROUND: A collagenoma or connective tissue nevus of the collagen type is a hamartoma consisting predominantly of collagen. Collagenomas are divided into the inherited and acquired types. The acquired forms include eruptive and isolated collagenoma. However, few studies have assessed the characteristics of patients with acquired collagenoma. OBJECTIVE: The aim of this study was to analyze the clinical characteristics of patients with acquired collagenoma. METHODS: We reviewed the medical records and clinical photographs of 23 patients who had been diagnosed histopathologically with acquired collagenoma by biopsy during the last 12 years, from January 2002 to December 2013. In addition, 11 cases of eruptive or isolated collagenomas previously reported in the Korean literature were added. RESULTS: In total, 34 cases of acquired collagenoma were assessed. Of the 34 cases, 53% were men and 47% were women. The mean age at diagnosis was 20.0 years for the patients with eruptive collagenoma and 29.1 years for the patients with isolated collagenoma. In the cases of eruptive collagenoma, multiple, flesh-colored or whitish papules on the trunk were predominant. On the other hand, in the cases of isolated collagenoma, solitary, flesh-colored plaques on the palms or soles were common features. Collagenomas in most cases were asymptomatic (79.4%). However, some patients with collagenomas had other symptoms such as tenderness or pruritus. There was no traumatic history in any case. CONCLUSION: Our study showed that the clinical features of patients with acquired collagenoma share many similarities with those in previously reported studies, with some differences. This study is expected to help us understand and obtain more information on the clinical diagnosis of acquired collagenoma.
Subject(s)
Female , Humans , Male , Biopsy , Collagen , Collagen Type I , Connective Tissue , Diagnosis , Hamartoma , Hand , Medical Records , Nevus , PruritusABSTRACT
Eruptive collagenoma is an acquired connective tissue nevus composed predominantly of collagen. We present a case of eruptive collagenoma in a 13-years-old female who had asymptomatic multiple 3 to 9 mm sized flesh colored scattered papules on both limbs. In addition, the differential diagnosis and other types of cutaneous collagenomas are briefly discussed.
Subject(s)
Female , Humans , Collagen , Connective Tissue , Diagnosis, Differential , Extremities , NevusABSTRACT
Connective tissue nevus is not a true tumor, but rather a hamartoma involving various components of connective tissue. It presents as a slow-growing, painless, flesh-colored, or pink nodule or plaque that is evident from childhood. While any region of the body may be affected, there is a predilection for the trunk and extremities. A 20-month-old girl presented with three ipsilateral confluent popular plaques with zosteriform distribution that had formed over the previous 17 months on the left chest and abdomen. The patient remained asymptomatic. Unlike all previously reported cases demonstrating a single lesion, we report a connective tissue nevi in a child who presented with multiple unilateral zosteriform lesions, an unusual pattern of distribution without evidence of tuberous sclerosis complex.
Subject(s)
Child , Humans , Infant , Abdomen , Connective Tissue , Extremities , Hamartoma , Nevus , Thorax , Tuberous SclerosisABSTRACT
Papular elastorrhexis is a rare cutaneous disorder that occurs predominantly during adolescence. The disorder is characterized by asymptomatic indurated white or flesh papules showing decreased and fragmented elastic fibers in the dermis. We herein report on a 12-year-old girl with multiple asymptomatic white, nonfollicular, firm papules scattered on the extremities and trunk. Histological examination revealed focal areas showing increased layers of collagen fibers and decreased and fragmented elastic fibers in the upper dermis.
Subject(s)
Adolescent , Child , Humans , Collagen , Dermis , Diagnosis, Differential , Elastic Tissue , Extremities , NevusABSTRACT
BACKGROUND: The collagen type of connective tissue nevus is a hamartoma in which the amount of collagen is increased. It is divided into two groups:the inherited form that contains familial cutaneous collagenoma and shagreen patches in tuberous sclerosis, and the acquired form that contains eruptive collagenoma and isolated collagenoma. OBJECTIVE: The purpose of this study is to investigate the clinical and histopathological features of the collagen type of connective tissue nevus, along with considering the associated systemic or genetic disorders. METHODS: We retrospectively reviewed the medical records and biopsy specimens of 17 patients. RESULTS: We compiled the clinical data and histopathologic feature of 17 patients with the collagen type of connective tissue nevus. The ratio of males to females was 1:1.125 and the mean age of onset was 12.2 years for the patients with eruptive collagenoma and 43.7 years for the patients with isolated collagenoma. Eruptive collagenoma was disseminated on the trunk and arms, but 1 case of eruptive collagenoma was localized on the left thigh. Isolated collagenoma developed as a solitarily lesion on the various sites. The lesions of eruptive collagenoma were less than 1 cm, but the size of the isolated collgenoma varied from 0.5 to 4 cm. Three cases of eruptive collagenoma presented with white-color lesions, but the rest of the eruptive collagenoma and isolated collagenoma showed flesh-colored lesions. No case was combined with congenital or systemic disease. Histopathologically, there were increased thickened collagen bundles that were randomly arranged in the dermis. The elastic fibers were decreased and fragmented. CONCLUSION: The collagen type of connective tissue nevus is benign and rare, and its clinical and histopathologic characteristics are similar with those of other dermal tumors or reactive disorders. Exact knowledge about the collagen type of connective tissue nevus is needed to differentiate connective tissue nevus from several other disorders that have similar characters and to disclose the association with other diseases.
Subject(s)
Female , Humans , Male , Adjustment Disorders , Age of Onset , Arm , Biopsy , Collagen , Connective Tissue , Dermis , Elastic Tissue , Hamartoma , Medical Records , Nevus , Retrospective Studies , Thigh , Tuberous SclerosisABSTRACT
Nevus anelasticus is an elastic tissue disorder that is characterized by perifollicular papules and the fragmentation or absence of elastic tissue. A 17-year-old female presented with multiple erythematous papules on her lower back. These skin lesions first appeared a few years ago and at that time she presented with multiple, flat tapped, coalescing pinkish-red papules that were 0.5 to 1 centimeters in diameter. Histopathologic examination revealed the loss of elastic tissue, with fragmentation of the residual elastic fibers in the upper and mid dermis, and the pattern of the dermal collagen was normal. Herein we report on a rare case of nevus anelasticus and we review the relevant literature.
Subject(s)
Adolescent , Female , Humans , Collagen , Dermis , Elastic Tissue , Nevus , SkinABSTRACT
Collagenomas are considered to be connective tissue nevi composed predominantly of collagen. They can be hereditary or sporadic. We report herein a rare case of isolated collagenoma on the left side of the face and the left thigh without associated abnormalities, in a 30-year-old man. Histopathologically, the lesion consisted of thick collagen fibers, which was compatible with collagenoma.
Subject(s)
Adult , Humans , Collagen , Connective Tissue , Nevus , ThighABSTRACT
Eruptive collagenoma is a connective tissue nevus, which can occur even if there is no family history of the condition. We report a case of eruptive collagenoma in a 44-year-old woman, who had had multiple, variable-sized, yellowish papules on her neck since childhood. The histopathologic findings showed thickened, homogenized collagen fibers and decreased elastic fibers.
Subject(s)
Adult , Female , Humans , Collagen , Connective Tissue , Elastic Tissue , Neck , NevusABSTRACT
The eruptive collagenoma is a connective tissue nevus without family history. We report a case of eruptive collagenoma in a 5 year old boy, who had multiple, variable sized orange colored nodules on his back since birth. The histopathologic finding showed increased number and size of collagen fiber and increased dermal thickness.
Subject(s)
Child, Preschool , Humans , Male , Citrus sinensis , Collagen , Connective Tissue , Nevus , ParturitionABSTRACT
The connective tissue nevus represents a hamartoma of various components of dermal connective tissue elements, predominantly collagen, elastin, or glycosa minoglycan. Zosterriform connective tissue nevus, described by Steiner, in 1944, clinically shows grouped papules in a zosteriform band without extracutaneous manifestations of family history, and peculiar histopathologic findings. We experienced 3 cases of typical zosteriforrn connective tissue nevus developed on the flank area of 30-year-old male and 21-year-old male, and on the inguinal area of 15-year-old female.