ABSTRACT
Since December 2019, there has been a sharp increase in the number of confirmed cases of pneumonia caused by the novel coronavirus (SARS-CoV-2) in China, which has caused great concern around the world. In face of severe epidemic, no specific drugs have been found in clinical practice. However, some Chinese medicine compounds have shown obvious clinical efficacy, and it is feasible to find and develop natural drugs for the treatment of novel coronavirus pneumonia from these compounds. In this paper, based on the recommends of new type of coronavirus infection pneumonia diagnosis and treatment scheme (trial version 6), the use frequency of Chinese herbal medicines was calculated. The antiviral reports of high frequency Chinese herbal medicines were reviewed, in order to provide the reference for screening the active components against SARS-CoV-2 from traditional Chinese medicine.
ABSTRACT
In December 2019, a new type of coronavirus pneumonia emerged and spread rapidly, but there is no specific antiviral vaccine or drug. At present, traditional Chinese Medicine (TCM) prevention and treatment programs have been introduced in many places in China. This paper systematically reviews and summarizes the etiology and pathogenesis of novel coronavirus pneumonia 2019 (COVID-19), the prevention programs for different populations in different regions and the treatment programs by stages. We analyzed the TCM prevention and treatment programs of COVID-19 in various regions and the clinical characteristics of the first-line patients. It is verified that the disease belongs to the category of "wet poison epidemic" according to TCM, and the disease is located in the lung and the spleen. The core pathogenesis of the disease is "dampness, heat, poison, blood stasis and deficiency" because of the rage of the disease. According to the relevant plan, TCM prevention should adopt different prescriptions according to the constitution of different populations and pay attention to comprehensive prevention according to different climates, regions and populations. Treatment should focus on eliminating filth and resolving turbidity, with clearing dampness as the key point. The corresponding treatment plan should be made according to the development of the disease, and the treatment should be divided into five stages (observation stage, initial stage, middle stage, severe stage and convalescence stage) according to the rules of syndrome development. Through the systematic analysis of the progress of TCM applied in various regions during the epidemic period, this paper hopes to provide useful help and guidance for the prevention and control of the epidemic and rational application and further research on the clinical treatment with TCM.
ABSTRACT
Objective: To summarize the main characteristics of clinical studies regarding coronavirus disease 2019 (COVID-19) registered on the Chinese and US NIH Official Clinical Trial Registration Websites. Methods: To search all the clinical studies about COVID-19 which were registered on the Chinese and U.S. NIH official clinical trial registration websites until March 9, 2020. The search terms were "new coronavirus pneumonia (COVID-19), 2019-nCoV, novel coronavirus pneumonia". Results: Overall, 360 studies with a total sample size of 268, 773 participants are registered on Chinese clinical trial registration website, and 74 studies with a total sample size of 73, 723 participants in the U.S. NIH clinical trial registration website. According to the information provided by the Chinese Clinical Trial Registration Website, there are 237 interventional studies, 108 observational studies, and 15 diagnostic test studies; and the most commonly studied interventions were Traditional Chinese Medicine in 80 studies, antiviral therapy in 58 studies, stem cells in 19 studies, plasma of recovered patients in 13 studies, glucocorticoid in 7 studies, molecular targeted therapy in 4 studies, and vaccine in 2 studies. According to the information provided by the U.S. NIH Clinical Trial Registration Website, there were 54 interventional studies, 17 observational studies, and 3 diagnostic test studies; and the most commonly studied interventions were antiviral therapy in 16 studies, stem cells in 7 studies, Traditional Chinese Medicine in 6 studies, molecular targeted therapy in 3 studies, and vaccine in 3 studies. Conclusions Numerous clinical studies related to COVID-19 have been registered during a very short period. Among them, Traditional Chinese Medicine is the most commonly studied intervention, which suggests the Chinese characteristics in medical care. However, considering such a large sample size needed for these clinical studies, it is very important to ensure the enrollment of participants effectively and orderly in future.