ABSTRACT
Primary cutaneous cribriform apocrine carcinoma is a rare but distinct variant of primary cutaneous apocrine carcinoma and it is considered a low grade malignancy. We herein present a case of primary cutaneous cribriform apocrine carcinoma at the neck of a 26-year-old female. The tumor features a relatively well-circumscribed border and multiple aggregations of mildly pleomorphic epithelial cells with large ovoid nuclei, small nucleoli and abundant eosinophilic cytoplasms. Cribriform and tubular structures are the major architectural patterns. The primary differential diagnosis is cutaneous metastasis from a cribriform visceral carcinoma; others include primary secretory carcinoma of the skin, adenoid cystic basal cell carcinoma and primary cutaneous adenoid cystic carcinoma.
ABSTRACT
Objective To analyze MRI features of invasive cribriform carcinoma of the breast,and to improve the diagnostic accuracy of the disease.Methods MRI of 10 cases with biopsy-proved invasive cribriform carcinoma of the breast in our hospital were analyzed retrospectively.Results 10 cases with invasive cribriform carcinoma of the breast showed unclear boundary.Lesions showed isointensity on T1 WI,and hyperintensity on T2 WI partially with point-like low signal intensity.After contrast administration,the lesions showed heterogeneous enhancement,most of which showed point-like low signal intensity in the lesions,which may be the characteristic manifestations of invasive cribriform carcinoma of the breast.The patterns of time-signal intensity curves were washout type and platform type.Five cases had lymph node metastasis,which may due to the overexpression of PR.Conclusion MRI plays an important role in the diagnosis of invasive cribriform carcinoma of the breast.There is a promising benefit of this radiation-free technique for selecting the optimal therapeutic regimen for this disease.
ABSTRACT
Glassy cell carcinoma is an unusual neoplasm of the uterine cervix with highly aggressive clinical behavior. On cervico-vaginal smear examination, the tumor has well confused of atypical repair cell of the endocervix. Recently, we have experienced two cases of glassy cell carcinoma of the uterine cervix, diagnosed on cervico-vaginal smears and confirmed on following histologic sections. The cervico-vaginal smears revealed abundant clusters with well defined boarders. The cell clusters were composed of large tumor cells. The tumor cells had distinct granular cytoplasm and eosinophilic macronucleoli. Characteristic cytologic features of this tumor were discussed in view of differential diagnosis.