ABSTRACT
Cutaneous B-cell pseudolymphoma (CBPL) is a reactive B-cell hyperplasia that clinically and histologically mimics cutaneous B-cell lymphoma (CBCL). Many different terms have been used to describe this condition such as lymphocytoma cutis and cutaneous lymphoid hyperplasia. This condition typically present as a solitary nodule or papule over face (cheek, nose and ear lobe), chest and upper extremities, but multiple lesions may also be present. A variety of stimuli are known to induce this condition but most cases have an unknown cause. We report 2 cases of CBPL, the causes of which could not be ascertained.
ABSTRACT
The pseudolymphoma of the skin has the architectural and cytological features of a neoplastic proliferation of lymphoid tissue but pursue a benign course. Cutaneous B cell pseudolymphoma (CBPL) shares many histopathologic and clinical features with cutaneous B cell lymphoma (CBCL). Therefore, the differentiation between CBPL and CBCL is often very difficult, but it is important because each of them has a different therapeutic consequence. Recently, immunoglobulin gene rearrangement is considered as a reliable technique for differentiation of CBPL with CBCL. We herein report a case of idiopathic lymphocytoma cuffs, showing a typical nodular infiltrate of lymphocytes that formed a follicular germinal center resembling reactive lymph nodes with numerous tingible bodies, and that revealed a polyclonality in the immunoglobulin gene rearrangement.