ABSTRACT
No abstract available.
ABSTRACT
Cutaneous lymphadenoma is a rare distinctive benign adnexal tumor of unknown histogenesis. It usually presents as a slowly growing, skin-colored nodule on the head and neck. Histologically, this tumor is composed of dermal lobules with a biphasic pattern of epithelial and lymphoid cells. We report two additional examples of this peculiar neoplasm.
Subject(s)
Head , Lymphocytes , NeckABSTRACT
The histological and immunohistological features of two cases of cutaneous lymphadenoma was studied. A single, erythematous nodule with smooth surface developed on the face of both patients. The lesion slowly progressed. Histology revealed irregular epithelial lobules in the dermis which showed a peripheral palisaded border of basaioid-like cells as well as a center composed of clear cells. Some epithelial lobules and surrounding stroma were infiltrated by numerous small lymphocytes. Immunohistological study showed that the lymphocytic infiltration was predominantly composed of T cells (CD3 positive) along with a small number of B cells (CD20 positive). Within epithelial lobules and surrounded stroma, there were numerous dendritic cells that were positive for S-100 and CDia but negative for cytokeratin 7, cytokeratin 20 or carcino-embryonic antigen. In the center of epithelial lobules in one case, a few cells positive for epithe-lial membrane antigen and CD30 was observed. The diagnosis of cutaneous lymphadenoma was made according to the pathological and immunohistochemical findings, and the infiltration was predominated by CD3-positive lymphocytes in this uncommon epithelial neoplasm.
ABSTRACT
Cutaneous lymphadenoma is a benign epithelial neoplasm with lymphoepithelial infiltration that is supposed to be from a pilosebaceous origin. We report a 44-year-old man with a nodule on the pre-auricular area showing basaloid proliferation, intraepithelial lymphocytes and immature pilosebaceous structures. The findings of our case make it possible to diagnose a cutaneous lymphadenoma with follicular differentiation and supports this occurs as a variant form of nodular trichoblastoma with adamantinoid features.
Subject(s)
Adult , Humans , Lymphocytes , Neoplasms, Glandular and EpithelialABSTRACT
Cutaneous lymphadenoma (CL) is a rare, benign, epithelial neoplasm with a prominent lymphocyte infiltration of unknown histogenesis. Both pilosebaceous and eccrine origins have been suggested, and the current view is that CL is a variant of trichoblastoma with adamantinoid features. We report a case of cutaneous lymphadenoma which developed on the left postauricular area of a 46-year-old woman, plus a review of the related literature.