ABSTRACT
In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC value of 1.44 μmol·L and TI (Therapeutic Index) value of 15.59.
Subject(s)
Humans , Anti-HIV Agents , Pharmacology , Cell Line, Tumor , Cell Survival , Glucosides , Chemistry , Pharmacology , Toxicity , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Extracts , Chemistry , Pharmacology , Toxicity , Senna Plant , Chemistry , Triterpenes , Chemistry , Pharmacology , ToxicityABSTRACT
Medicinal plants in Cimicifuga L. contain triterpenoid glycosides, phenolic acids, chromones and other ingredients, showed biological activities of antitumor, anti-inflammatory, antiviral, anti-nucleoside transport, anti-osteoporosis, anti-oxidant, antidepression, etc, and have been used in the treatment of perimenopausal syndrome. This paper reviews the advances in studies on chemical constituents cimicifuga, focuses on the research progress of biological activities and clinical applications to provide a reference for further development of medicinal plants in Cimicifuga L.
ABSTRACT
Secocycloartanes are a class of triterpenoids with novel structures showing anti-HIV and antitumor activities. This review summarized the structures, bioactivities and plant distribution of secocycloartane triterpenoids reported from plants but Schisandraceae in recent years to provide a basis for further study of this type of compound and the discovery of new drugs.