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Objective To investigate the value of contrast-enhanced ultrasound (CEUS) in differential diagnosis of pancreatic pseudocysts,cystadenomas and cystadenocarcinomas,so as to improve diagnostic accuracy of the condition.Methods The results of CEUS and conventional ultrasound for 71 patients with pancreatic cystic lesions were analyzed retrospectively,and compared with the finally obtained surgical-pathological examination to assess the ability of qualitative diagnosis between two methods.Results In 71 pancreatic cystic lesions,there were 32 pancreatic pseudocysts,24 cystadenomas and 15 cystadenocarcinomas.The sensitivity and accuracy of CEUS for pancreatic pseudocysts and cystadenocarcinomas were 84.4％,93.0％ and 86.7％,88.7％,which were higher than those of conventional ultrasound 56.3 ％,80.3 ％ and 53.3 ％,74.6％ (x2 =6.06,4.92,3.97,4.71,all P ＜ 0.05).Conclusion There are some similarities in terms of imaging manifestations among pancreatic pseudocysts,cystadenomas and cystadenocarcinomas.Combining conventional ultrasound with CEUS can help the differential diagnosis of pancreatic cystic lesions.
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Background: Epithelial ovarian carcinoma is worldwide the sixth most common female cancer. This malignancy carries the highest mortality among all gynecological cancers. Aim and objectives: To perform and interpret p53 immunostaining on the diagnosed serous and mucinous malignant surface epithelial ovarian tumors and to correlate expression of p53 with histological type of malignancy. Materials and methods: 2 year prospective study was done i.e. from October 2011 to September 2013 on “p53 interpretation on surface epithelial ovarian tumors” in MGM Hospital, Warangal. All the ovarian surface epithelial tumor specimens, received in the pathology department during this period were considered. Results: A total of 120 cases were studied, out of which benign tumors were the most common (64.2%), followed by malignancy (25.8 %) and 12 cases (10%) of borderline malignancy. Most of the benign tumors were unilateral, the cases which showed bilateral involvement were mostly malignant. The maximum number of cases in the present study was seen in the age group of 31-60 years. The youngest patient was 16 years old and the oldest was 68 years old. Serous cyst adenoma was the most common neoplasm found and accounted for 53 cases (44.2%) , followed by mucinous cystadenoma, which accounted for 21 cases (17.5%). 9 cases of serous cystadenofibroma (7.5%), 3 borderline serous tumors (2.5%) and 11 serous cystadenocarcinoma (9.1%) were found in the present study. Out of the 44 mucinous tumors, 21 were benign (17.5%), 3 were of borderline malignancy (2.5%) and 20 were malignant (16.7%). One case of mucinous cystadenocarcinoma was found to be associated with T. T. Sreeja, S. Chandrasekhar, S. Lokesh Rao Magar, K. Durga. 2 years study on p53 expression on serous and mucinous tumors of ovary. IAIM, 2016; 3(7): 150-158. Page 151 adenocarcinoma of ascending colon. One case of benign Brenner tumour was also found in the present study. Conclusion: The rate of p53 abnormalities varies with histologic type, grade and stage of the tumor. P53 expression was more in malignant serous tumors as compared to the malignant mucinous tumors.
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ObjectiveTo investigate the correlation of Skp2,p27kiP1 and p21WAF1 expression with the clinicopathological features of ovarian serous cystadenocarcinomas.Methods Expressions of Skp2 ,p27kiP1 and p21WAF1 were examined by immunohistochemical staining in 124 epithelial ovarian tumors (25 serous cystadenomas, 19 borderline serous cystadenomas, and 80 serous cystadenocarcinomas) Results(1) The expression of Skp2 in serous cystadenocarcinomas (47.5％)was significantly higher than that in borderline serous cystadenomas (0％)and serous cystadenomas (0％)(P ＜ 0.001) .The p27kiP1 expression in serous cystadenocarcinomas (35.0％) was significantly lower than that in borderline serous cystadenomas(73.7％)and serous cystadenomas (80.0％) .The p21WAF1 staining frequency in serous cystadenocarcinomas (38.8％)was significantly lower than in borderline serous cystadenomas (73.7％)and serous cystadenomas (80.0％) .(2) The Skp2 protein expression in serous cystadenocarcinomas was positively correlated with clinicopathological stage,histological differentiation degree and lymph node metastasis of the tumors.The p27kiP1, p21WAF1 protein expression in serous cystadenocarcinomas was reversely correlated with clinicopathological stage and histological differentiation degree of the tumors(Ps ＜ 0.05) .(3) The Skp2 protein expression in serous cystadenocarcinomas was reversely correlated with that of p27kiP1 , p21WAF1.Conclusion The Skp2 protein expression in serous cystadenocarcinomas was increased and positively correlated with the clinicopathological features of ovarian serous cystadenocarcinomas.Skp2 protein expression was reversely correlated with p27kip1 ,p21WAF1.Skp2 protein expression may play an important role in the development and progression of serous cystadenocarcinomas.
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Objective To investigate the CT radiological features of pancreatic cystadenomas and cystadenocarcinomas. Methods The CT scans from 39 patients with pathologically proven cystic pancreatic tumors (21 cases of serous cystadenomas, 12 cases of mucinous cystadenomas, and 6 cases of mucinous cystadenocarcinomas) were retrospectively analyzed. Tumor location, the number of cyst (polycystic or not) , diameter of the largest cyst, features of the cyst wall, partition within cyst, border of tumor, and the relationship between tumors and pancreatic duct were recorded. Results In 21 patients with serous cystadenomas, tumors were located at the pancreatic head and neck areas in 17 cases, at the pancreatic body and tail areas in 5 cases, and 1 case was multiple. All 21 cases were polycystic; the median diameter of the largest cyst was 1.77 cm; calcification was seen in cyst wall or partition in 4 cases and soft tissue was seen in 7 cases; mild pancreatic duct dilatation was found in 10 cases. In 12 patients with mucinous cystadenomas, tumors were located at the pancreatic head and neck areas in 6 cases, at the pancreatic body and tail areas in6 cases; 4 cases were polycystic; the median diameter of the largest cyst was 4.88cm; calcification was seen in 1 case and soft tissue was seen in 6 cases; pancreatic duct dilatation was found in 2 cases and mild duct dilatation was found in 3 cases. In 6 patients with mucinous cystadenocarcinomas, tumors were located at the pancreatic body and tail areas in 5 cases, tumor was located at the pancreatic head and neck areas in 1 case; 4 cases were polycystic; the median diameter of the largest cyst was 5.09 cm; calcification was seen in 1 case and soft tissue was seen in 5 cases; duct dilatation was found in 1 case. In all cases, there was no pancreatic duct communication. After enhancement, the soft tissue and partition of lesion was enhanced to gome extent. Conclusions There are CT radiological features of pancreatic cystadenomas and cystadenocarcinomas. However, there are still some atypical CT appearances that may challenge the diagnosis.
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Os tumores císticos mucinosos do pâncreas são neoplasias epiteliais císticas compostas por células colunares produtoras de mucina e comportamento semelhante ao cistoadenoma de ovário e fígado com propensão a degeneração maligna. São neoplasias raras que correspondem a menos de 5 % dos tumores pancreáticos, acometendo mais frequentemente as mulheres, com predomínio em pacientesjovens. Relata- se o caso de uma paciente de 47 anos, sexo feminino, que iniciou com desconforto na região mesogástrica, progressivo durante o puerpério associado a aumento do volume abdominal. Exames de imagem revelaram lesão cística na topografia do pâncreas. Foi realizada umaPancreatectomia corpo-caudal e esplenectomia no qual se confirmou o diagnóstico de Cistoadenocarcinoma invasivo da cauda do pâncreas medindo 12 centímetros. Não existe no momento consenso em relação ao tratamento adjuvante.
Mucinous cystic tumors of the pancreas are cystic epithelial neoplasms composed of columnar cells producing mucin-like behavior and cystadenoma of ovary and liver are prone to malignancy. Are rare neoplasms that account for less than 5% of pancreatic tumors, most often affecting women, predominantly in young patients. We report the case of a 47-year-old female, who started with discomfort in the mesogastric, progressive during the postpartum period associated with increased abdominal volume. Imaging examinations revealed a cystic lesion in the topography of the pancreas. We performed a body-tail pancreatectomy and splenectomy in which it confirmed the diagnosis of invasive cystadenocarcinoma of the tail of the pancreas measuring 12cm. There is no currently consensus regarding adjuvant treatment.
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Salivary gland papillary cystadenocarcinomas are rare lesions, and particularly when they are found in the oral cavity. They have been recognized as being low grade carcinomas of the salivary glands. The author reports here on a case of recurrent papillary cystadenocarcinoma in the right retromolar area. The initial mass had multicystic and papillary structures with low grade features. The recurred mass showed basically the same histologic features. However the layer of papillae and the solid portion were increased and the tumor cells were larger and more pleomorphic with prominent nucleoli and frequent mitoses. Focal comedo type tumor necrosis and spindle cell proliferations in the surrounding soft tissue were present. This is a very rare report of a minor salivary gland papillary cystadenocarcinoma in a Korean, and the morphologic dedifferentiation was accompanied by the clinical recurrence.