Incidence of urinary tract infection after cystography / Incidência de infecção urinária após cistografia

ABSTRACT Objective: Cystography an invasive procedure with potential complications such as urinary infection (UI). There are few studies about the incidence of complications associated with this procedure. The purpose of this study is to evaluate the incidence of post-cystography urinary infection (UI.). Methods: Retrospective study with a review of clinical records of patients under 15 years of age, followed in this hospital, who underwent cystography (radiologic or indirect radionuclide) between 2009 and 2018. Post-cystography UI was defined when it occurred until seven days after the procedure. Descriptive and nonparametric statistics were applied to assess possible predictive factors related with post-cystography UI. Results: In the study period, 531 cystograms were undertaken (55% indirect radionuclide and 45% radiologic). The mean age at the procedure was 11.5 months; 62% were boys. Every patient had a previous negative urine culture; 50% were under antibiotic prophylaxis at the time of the procedure. The most common indication for the procedure was the post-natal study of congenital hydronephrosis/other nephrological malformation (53%), followed by the study of febrile UI (31%). Vesicoureteral reflux (VUR) was diagnosed in 40% of procedures. Post-cystography UI occurred in 23 cases (incidence of 4.3%). The most frequent microorganism was E. coli (52%). The presence of VUR was significantly associated with the occurrence of post-cystography IU. Conclusions: The incidence of post-cystography UI was low in our sample. The presence of VUR was significantly associated with the occurrence of post-cystography UI. The authors highlight the importance of an adequate catheterization technique and the need for clinical surveillance after the procedure.

RESUMO Objetivo: A cistografia é um exame invasivo que apresenta potencial iatrogenia, nomeadamente infecção urinária (IU). Os estudos sobre a incidência de complicações associadas a esse exame são escassos. O objetivo deste trabalho foi avaliar a incidência de IU após realização de cistografia. Métodos: Estudo retrospetivo por consulta dos prontuários clínicos dos doentes com idade inferior a 15 anos, seguidos em consulta nesse hospital, que realizaram cistografia (radiológica ou isotópica) entre 2009 e 2018. Admitiu-se relação de causalidade quando o diagnóstico de IU ocorreu até sete dias após a realização do exame. Foi realizada análise estatística descritiva e utilizados testes não paramétricos para avaliar possíveis fatores preditores da ocorrência de IU após cistografia. Resultados: Realizaram-se 531 cistografias (55% isotópicas e 45% radiológicas). A mediana de idade foi de 11,5 meses; 62% eram do sexo masculino. Todos os doentes efetuaram urocultura prévia (negativa); 50% recebiam profilaxia antibiótica (ATB) à data do exame. A indicação mais frequente foi o estudo pós-natal de hidronefrose (HN) congênita/outra malformação nefrourológica (53%), seguida do estudo da IU febril (31%). Documentou-se refluxo vesicoureteral (RVU) em 40% dos exames. Ocorreu IU após cistografia em 23 casos (incidência de 4,3%). O microrganismo mais frequente foi a E. coli (52%). Verificou-se associação entre a presença de RVU e a ocorrência de IU. Conclusões: A incidência de IU pós-cistografia foi relativamente baixa na amostra deste estudo. Observou-se associação entre a ocorrência de IU após cistografia e a presença de RVU. Sublinha-se a importância de uma técnica adequada de cateterização vesical e da vigilância clínica após o exame.

Utilization of pretransplant cystography and hydrodistention among anuric patients on renal replacement therapy and its impact on cost and timing of transplantation

OBJECTIVE@#To describe utilization of pretransplant cystography and hydrodistention among anuric end stage renal disease patients (ESRD) on renal replacement therapy (RRT) and its impact on cost and timing of transplantation.@*METHODS@#A chart review was done on all anuric ESRD pretransplant patients on renal replacement therapy who underwent cystography and hydrodistention from 2014 to 2019. The authors analyzed patient demographics, post-transplant outcomes, process indicators and costs incurred due to cystography and hydrodistention.@*RESULTS@#A total of 151 patients were included in the study. There was female predominance (86, 57%) with a median age of 32 (range 18-61) years. Majority of the patients underwent hemodialysis (144, 95%). Glomerulonephritis was the prevailing etiology of ESRD (119, 79%). Majority had normal bladder capacity (107, 71.5%), while 44 (29%) patients had small bladder capacity who subsequently underwent hydrodistention. There is a moderately negative correlation between bladder capacity and duration of dialysis and anuria. Hydrodistention did not significantly increase duration from diagnosis to kidney transplant (4.2 vs 3.5 months; p = .083). Median cost of cystography was Php 4377 (range 1978 – 5282) and the average total cost incurred per patient due to hydrodistention was Php 643.53.@*CONCLUSION@#Longer duration of RRT and anuria yields to lesser bladder capacity. Cystography is recommended in ESRD patients who are anuric for at least three years. Hydrodistention does not significantly prolong duration of diagnosis to kidney transplant.

Is computed tomography cystography indicated in children with pelvic fractures? / 中华创伤杂志(英文版)

PURPOSE@#Pelvic fracture evaluation with abdominopelvic computed tomography (CT) and formal CT cystography for rule out of urine bladder injury have been commonly employed in pediatric trauma patients. The additional delayed imaging required to obtain optimal CT cystography is, however, associated with increased doses of ionizing radiation to pelvic organs and represent a significant risk in the pediatric population for future carcinogenic risk. We hypothesized that avoidance of routine CT cystography among pediatric pelvic fracture victims would not result in an appreciable rate of missed bladder injuries and would aid in mitigating the radiation exposure risk associated with these additional images.@*METHODS@#A retrospective cohort study involving blunt trauma pelvic fractures among pediatric trauma patients (age<14) between the years 1997 and 2016 was conducted utilizing the Israeli National Trauma Registry. Statistical analysis was performed using SAS statistical software version 9.4 via the tests of Chi-square test and two-sided Fisher's exact test. A p value of less than 0.05 was considered statistically significant.@*RESULTS@#A total of 1072 children were identified from the registry for inclusion. Mean age of patients was 7.7 years (range 0-14) and 713 (66.5%) were male. Overall mortality in this population was 4.1% (44/1072). Only 2.1% (23) of pediatric patients with pelvic fractures had bladder injury identified, with just 9 children having intraperitoneal bladder rupture (0.8% of all the patients).@*CONCLUSION@#The vast majority of blunt pediatric trauma victims with pelvic fractures do not have urine bladder injuries. Based on our study results we do not recommend the routine utilization of CT cystography in this unique population.

The Effectiveness of Cystography-Measured Bladder Neck Elevation at Predicting the Return of Continence After Robot-Assisted Radical Prostatectomy / 대한배뇨장애요실금학회지

PURPOSE: To analyze the clinical parameters correlated with early recovery of urinary continence after radical prostatectomy, with a focus on urethral mobility during pelvic contraction at catheter removal. METHODS: We prospectively analyzed 67 patients who underwent prostatectomy for prostate cancer at Jeju National University Hospital from January 2015 to June 2018. At the time of catheter removal, a cystography was performed in 67 men (median age, 65 years; range, 55–76 years) who had undergone robot-assisted laparoscopic prostatectomy. The vertical length of bladder neck movement between relaxing and contracting the pelvic muscles was measured. The correlation between the rate of continence recovery and the length of urethral movement was also assessed. All participants were divided into 2 groups according to the length of bladder neck elevation. Group 1 had ≥0.6 cm of elevation, while group 2 demonstrated <0.6 cm of elevation. RESULTS: A reverse correlation existed between the length of urethral movement and the recovery rate of urinary continence (r=–0.488, P<0.001). The optimal cutoff value for length of urethral movement was found to be 0.6 cm among patients (area under the curve, 0.703). A statistically significant difference was observed between group 1 (length≥0.6 cm) and group 2 (<0.6 cm) (P<0.05). Multivariate regression analysis showed that urethral movement predicted the postoperative urinary incontinence. CONCLUSIONS: The extent of bladder neck elevation after robot-assisted laparoscopic prostatectomy, which can be easily evaluated using cystography, may be a good predictor of the recovery of urinary continence.

Nuclear Imaging in Pediatric Kidney Diseases

Renal scintigraphy is a useful tool in diagnosis and management of various nephro-urological conditions. Tc-99m dimercaptosuccinicacid renal scintigraphy (Tc-99m-DMSA), Tc-99m mercaptoacetyltriglycine (Tc-99m-MAG3) or Tc-99m diethylenetriaminepentaaceticacid (Tc-99m-DTPA) dynamic renal scintigraphy, and Radionuclide micturating cystography are the common scans used in children withkidney diseases. These studies are minimally invasive, easily available, and offer both anatomic details and functional informationrequired for thorough evaluation. At the same time, it is essential to have appropriate knowledge to interpret these studies and be awareof their limitations and pitfalls. The advent of Positron emission tomography-computed tomography/magnetic resonance imaging (PET-CT/MRI) has broadened the scope of nuclear medicine. This article focuses on the technique, interpretation, indication and recentpractice guidelines of renal scintigraphy in children with kidney diseases.

Extravasation of the Contrast Material During Voiding Cystourethrography in a Chronic Spinal Cord Injury Patient: A Case Report

Neurogenic bladder is common in most spinal cord injury patients. Voiding cystourethrography (VCUG) is recommended in these patients to detect urinary tract complications. However, rare but serious complications may occur during VCUG, although VCUG is generally safe. There are several case reports of bladder rupture occurring in pediatric patients. Here, we report the first case of iatrogenic bladder rupture in an adult spinal cord injury patient in Korea. Particularly, extravasation of contrast without manual instillation has hardly ever been reported. To the best of our knowledge, this is the first reported case of bladder rupture without manual instillation during VCUG. We report a case of a 59-year-old female with paraplegia due to tuberculous spondylitis who underwent VCUG as a part of routine evaluation of neurogenic bladder. Extravasation of the contrast media during VCUG developed as a complication and the patient recovered spontaneously without any intervention. Therefore, VCUG should be performed properly in chronic spinal cord injury patients.

Digital Subtraction Cystography for Detection of Communicating Holes of Spinal Extradural Arachnoid Cysts

OBJECTIVE: The purpose of this study was to demonstrate the usefulness of digital subtraction cystography to identify communicating holes between a spinal extradural arachnoid cyst (SEAC) and the subarachnoid space prior to cyst removal and hole closure. MATERIALS AND METHODS: Six patients with SEAC were enrolled in this retrospective study. Digital subtraction cystography and subsequent CT myelography were performed for every patient. The presence and location of the communicating holes on cystography were documented. We evaluated the MRI characteristics of the cysts, including location, size, and associated spinal cord compression; furthermore, we reviewed cystographic images, CT myelograms, procedural reports, and medical records for analysis. If surgery was performed after cystography, intraoperative findings were compared with preoperative cystography. RESULTS: The location of the communicating hole between the arachnoid cyst and the subarachnoid space was identified by digital subtraction cystography in all cases (n = 6). Surgical resection of SEAC was performed in 4 patients, and intraoperative location of the communicating hole exactly corresponded to the preoperative identification. CONCLUSION: Fluoroscopic-guided cystography for SEAC accurately demonstrates the presence and location of dural defects. Preoperative digital subtraction cystography is useful for detection of a communicating hole between a cyst and the subarachnoid space.

Uretrocistografía en niños: percepción de los padres / Uretrocystography in children: parents' perception

Voiding cystourethrography (VCUG) has been usually considered as a painful and badly tolerated procedure in children. This opinion is not agreed with local experience of the authors. Objective: To evaluate the parent's perception about VCUG in children before and after the procedure. Methods: In 2009, parents of children who carne to Radiology Department for a VCUG completed an anonymous survey, including age and sex of their children, physician referent specialty, information received about the exam, expectation before and opinion after the procedure. Results: During 12 months 86 surveys were evaluated; patient's age was ranged between 1 month to 8 years with 52.3 percent> (45) girls and 47.7 percent> (41) males. Patients were referred from general pediatric in 59 percento or nephrology practice in 33 percent>; 20 percent> of the patients did not receive any information about the procedure before. About the expectation of VCUG, previous the exam, parents considered the examination as a pediatrician visit in 2.3 percent, uncomfortable in 26.7 percent>, a little painful in 16.3 percent, painful in 21 percent and aggressive or terrible in 33.7 percento. After the examination, parents' opinion was: 24.4 percent> as a pediatrician visit, 45.3 percent> uncomfortable, 22.1 percento a little painful, 4.7 percent> painful and 3.5 percent> aggressive or terrible. The global parents' perception about VCUG after the exam improved in 66 percent> cases, did not change in 29 percent> and went worse in 5 percent. Conclusion: Parent's perception about VCUG in children significantly improves after the procedure; in 91.8 percent> the examination was considered uncomfortable or only a little painful.

Con frecuencia se califica a la uretrocistografía miccional (UCG) como un examen doloroso y mal tolerado por los niños, lo que resulta discordante con la experiencia de los autores. Objetivo: Evaluar la percepción de los padres de las UCG efectuadas a sus hijos, antes y después del examen. Durante el año 2009, en el Servicio de Radiología de Clínica Las Condes, se solicitó a los padres contestar anónimamente una encuesta que incluía: edad y sexo del niño, especialidad médico solicitante, información recibida respecto del examen, explicitar expectativas antes del examen y opinión posterior. Se evaluaron 86 encuestas; edades: 1 mes a 8 años; 52,3 por ciento (45) niñas y 47,7 por ciento (41) varones; pediatra deriva 59 por ciento y nefrólogo 33 por ciento; 20 por ciento no recibió información del solicitante. Antes del examen: 2,3 por ciento como una visita al pediatra, 26,7 por ciento molesto, 16,3 por ciento un poco doloroso, 21 por ciento doloroso y 33,7 por ciento agresivo/terrible. Después de la UCG: 24,4 por ciento como una visita al pediatra, 45,3 por ciento molesto, 22,1 por ciento un poco doloroso, 4,7 por ciento doloroso y 3,5 por ciento agresivo/terrible. Post-examen: 66 por ciento mejora la percepción, 29 por ciento mantiene y 5 por ciento empeora. Conclusiones: La percepción de los padres mejora significativamente después de efectuado el examen; el 91,8 por ciento considera el examen como molesto o un poco doloroso.

Cystography helps Shorten urethral catheterization time after radical retropubic prostatectomy.

Objective: Post operative urethral drainage after radical retropubic prostatectomy is bothersome to patients. We assessed the possibility of using cystography to determine the feasibility and safety of early removal of urinary catheter. Methods: 56 patients who underwent radical retropubic prostatectomy from February 2001- December 2004 by one surgeon using one operative technique were reviewed. Cystography was performed on post-operative day 7 in the last 14 consecutive cases (group 1). The control group included 42 patients who had the urinary catheter removed 14 days postoperatively without cystography (group 2). In group 1, the urinary catheter was removed if cystogram showed no contrast media leakage. Data of the operations, pathological reports, complications and incontinence rate were compared between the two groups. Results: In group 1, the urinary catheter was removed on post-operative day 7 in 71% of the patients. The median catheterization time was 7 days and 14 days in group 1 and group 2, respectively (p<0.001). The incontinence rate was not significantly different in the two groups. There was no voiding difficulty or urinary retention reported in group 1. Conclusion: Cystography alleviates urethral discomfort after radical retropubic prostatectomy by shortening urinary catheterization time. Cystography should be considered in all patients who undergo radical retropubic prostatectomy on post-operative day 7. A meticulous urethrovesical anastomosis is required to reduce urinary catheterization time.

Malformaciones congénitas genitourinarias como factor etiopatogénico en la infección de vías urinarias del lactante / Congenital defects of genito-urinary system as a factor that causes urinary tract infection in newborns

Estudio multicéntrico, retro-prospectivo, longitudinal realizado en los hospitales de niños “León Becerra” y “Dr. Francisco de Ycaza Bustamante”, en lactantes de 0–30 meses de edad, con infección de vías urinarias (IVU) comprobada por urocultivo, a los cuales se les realizó pruebas de orina, sanguíneas y radiológicas, para lograr un estudio completo del paciente y determinar si existían malformaciones congénitas del tracto urinario.Objetivos: Detectar malformaciones génito-urinarias congénitas en lactantes de 0-30 meses de edad.Prevención del daño renal progresivo y sus consecuencias.Contribuir con alternativas prácticas y oportunas a la solución de las complicaciones médico-quirúrgicas de la IVU en lactantes.Resultados: De 78 pacientes, el 58% fueron del sexo masculino. En el 65% del universo se encontró como causante de la infección a la E. coli. La fiebre por encima de 38°C se presentó en el 98% de los casos. El 22% de los pacientes presentaron malformaciones congénitas de las vías urinarias. La malformación congénita genitourinaria más común fue el reflujo vésicoureteral que se presentó en 9 pacientes. En lo que a recurrencias de infección se refiere, de los 78 casos estudiados, el 67% presentaron recurrencias. De los 17 (100%) pacientes que presentaron malformaciones, 15 (88%) presentaron como antecedente I.V.U. recurrentes.Conclusiones: La IVU sigue siendo una enfermedad de alta prevalencia en los lactantes, afectando más al sexo masculino en esta edad. La Escherichia coli, fue el agente etiológico más frecuente. El síntoma más común fue la fiebre >38° C. Las malformaciones congénitas del tracto urinario son un factor etiopatogénico importante en la IVU ya que tienen una prevalencia del 22%.

A multicentric, retro-prospective, longitudinal study was done at the “Leon Becerra” Children Hospital and “Dr. Francisco of Ycaza Bustamante” Children Hospital, in newborns of 0–30 months of age with urinary tract infection (UTI) checked by urine culture. Urine, blood, and radiological exams were done to determine if congenital defect of the genito-urinary tract existed. Objectives: Detector genito-urinary defect congenital in newborns to 0-30 months.Prevention of the progressive renal damage and their consequences. To contribute with practical and opportune alternatives to the solution of this clinical-surgical problem. Results: Of 78 patients, 58% were male babies. In 65% of the universe E. Coli was the agent causing infection. The fever above 38°C was presented in 98% of the cases. 22% of the patients presented congenital defects of the urinary tract. The most common congenital defect in our study was vesicoureteral reflux that 9 patients in our study had. In what refers to recurring infections, of the 78 studied cases; 67% presented recurrences. Of the 17 (100%) patient that had congenital defect, 15 (88%) had history of recurring U.T.I. Conclusions: The UTI continues being an illness of high prevalence in the newborns, affecting male babies at this age. The Escherichia coli was the agent most frequently produces infection. The most common symptom was fever >38°C. The congenital defects of the urinary tract are an important factor in the UTI with a prevalence of 22%.

The Diagnostic Value and Use of Computerized Tomography in Bladder Rupture / 대한비뇨기과학회지

PURPOSE: We present our experience with computerized tomography (CT) for diag nosing bladder rupture in patients with blunt abdominal and/or pelvic trauma, and compare the results of CT with those of retrograde cystography. MATERIALS AND METHODS: We reviewed 52 consecutive cases diagnosed as bladder rupture at our hospital from September 1993 to June 2000. Of them 25 cases under went retrograde cystography and CT scan simultaneously. After CT scan, post-CT KUB were taken in all cases. Blind readings of CT scans were performed by one radiologist, and the presence or diagnostic accuracy of bladder rupture was evaluated. RESULTS: Of the 25 cases, 21 cases (84%) were accurately diagnosed with CT scan alone. With retrograde cystography, diagnosis was made in 23 cases (92%), and 2 cases had no definite finding of bladder rupture. On post-CT KUB, bowel loop highlighting or perivesical extravasation of contrast media was noted in 20 cases (80%) of 25 cases. This finding also contributed to the diagnosis of bladder rupture and evaluation of upper collecting system. With CT scan, other intra-abdominal injuries were found in 9 cases (36%) and 5 cases of them underwent additional operations. CONCLUSIONS: In patients with bladder rupture, evaluation of intra-abdominal injury or upper urinary tract are impossible with retrograde cystography alone. If CT scan is properly performed with pre and post-CT KUB in the initial evaluation, more accurate diagnosis and immediate surgical repair are possible in combination with retrograde cystography.

Vesicoureteral reflux caused by benign prostatic hyperplasia / 中华泌尿外科杂志

Objective To study the correlation between benign prostatic hyperplasia (BPH) and vesicoureteral reflux (VUR). Methods Intravenous radionuclide cystography (IVRC) was performed on 88 BPH patients and micturition cystourethrography on 30 to find if there was any VUR and the degree of reflux. Results 31 patients had VUR of which there were 6 grade Ⅰ,7 grade Ⅱ,6 grade Ⅲ,6 grade Ⅳ and 6 grade Ⅴ.9 were on the right,6 on the left and 16 bilateral. Conclusions VUR do occur in some BPH patients and IVRC is the better method for its diagnosis and evaluation.

Pred ictive Efficacy of Radioisotope Voiding Cystography for Renal Outcome / 대한핵의학회잡지

PURPOSE: As vesicoureteral reflux (VUR) could lead to renal functional deterioration when combined with urinary tract infection, we need to decide whether operative anti-reflux treatment should be performed at the time of diagnosis of VUR. Predictive value of radioisotope voiding cystography (RIVCG) for renal outcome was tested. MATERIALS AND METHODS: In 35 children (18 males, 17 females), radiologic voiding cystourethrography (VCU), RIVCG and DMSA scan were performed. Change in renal function was evaluated using the follow-up DMSA scan, ultrasonography, and clinical information. Discriminant analysis was performed using individual or integrated variables such as reflux amount and extent at each phase of voiding on RIVCG, in addition to age, gender and cortical defect on DMSA scan at the time of diagnosis. Discriminant function was composed and its performance was examined. RESULTS: Reflux extent at the filling phase and reflux amount and extent at postvoiding phase had a significant prognostic value. Total reflux amount was a composite variable to predict prognosis. Discriminant function composed of reflux extent at the filling phase and reflux amount and extent at postvoiding phase showed better positive predictive value and specificity than conventional reflux grading. CONCLUSION: RIVCG could predict renal outcome by disclosing characteristic reflux pattern during various voiding phases.

The Diagnostic Value of Cystography with Low-concentration Contrast Medium in Diagnosing Small Tumor of Urinary Bladder / 实用放射学杂志

Objective To evaluate the value of cystography with low-concentration contrast medium in diagnosing small tumor of urinary bladder.Methods Cystography in 187 cases with bladder disease from 1992 to 2001 was performed using 6%～8% Meglumine Diatrizoate 100～120 ml under TV monitored.Radiogrames of A-P position and bilateral oblique position were taken when the focus was found.The radiogram on patient’s position at head low was adopted when necessary.Results Of 187 cases,106 cases of bladder tumors were detected,including 8 cases of small bladder tumor(≤1.0 cm in diameter),3 cases were misdiagnosed,the detectable rate was 73.0%.All cases were confirmed by operation and pathologiy.In these 8 cases,1 case was adenocarcinoma,5 cases were transitional epithelia cell carcinoma,2 cases were papilloma.The X-ray appearances were nipple-like or cauliflower shape with filling defect,a narrow pedicel could be occasionally found in papilloma or transitional epithelia cell carcinoma and it had somewhat movement when changed patient’s position.Conclusion Cystography with low-concentration contrast medium is a non-injury procedure in diagnosis of small tumor of urinary bladder.

Three Cases of Cystitis Confused with Bladder Tumor on the Cystogram / 대한비뇨기과학회지

Three cases of cystitis are described which showed irregular filling defect on the excretory cystogram and were confused with the proliferative neoplasm of bladder. Urine examination, cystoscopy and biopsy demonstrated chronic non-specific cystitis in two cases and tuberculous cystitis in another one.