ABSTRACT
Objective To investigate the relationship between serum visfatin and glucose metabolism disorder in patients with polycystic ovary syndrome.Methods Seventy eight patients with polycystic ovary syndrome (PCOS) were selected,and,according to the results of glucose tolerance test and insulin release test (OGTT),were divided into normal OGTT without insulin resistance (NONIR) group (n =32 cases),OGTT normal with hyper insulinemia (HI) group (n =25 cases),and OGTT abnormalities that may be associated with hyper insulinemia (also known as abnormal glucose metabolism (AGM) group; n =21 cases).Sixteen cases of tubal infertility women were selected as control group in the same period.The relationship between serum visfatin and glucose metabolism was analyzed and related to various factors.The changes of relevant indicators of PCOS patients who were treated before and after treatment were observed in AGM group.Results In AGM Group,PCOS patient's menstrual cycle,testosterone (T),luteinizing hormone (LH)/follicle stimulating hormone (FSH),visfatin,triglyceride (TG),homeostasis model assessment of insulin resistance (HOMAIR) were higher than control group (P ＜ 0.05).The age at menarche,menstrual cycles,infertility time,waist-hip ratio (WHR),systolic blood pressure,T,estradiol (E2),and LH/FSH were no significant difference between AGM group versus NONIR group or HI group (P ＞0.05).However,the body mass index (BMI),waist circumference,diastolic blood pressure,HOMA-IR,and TG in AGM group were significantly higher than NONIR group,and older than HI group; visfatin in AGM group was higher than NONIR group or HI group (P ＜ 0.05).Visfatin was positively correlated with BMI,waist circumference,fasting insulin (FINS),fasting plasma glucose (FPG),HOMA-IR,and TG (r =0.423 ～ 0.847,P =0.01 ～ 0.04).After 3 months of treatment,8 cases AGM patients' serum visfatin,HOMA-IR,and blood pressure were significantly decreased (P ＜ 0.05).Conclusions High serum visfatin may be one predictor of glucose metabolism in patients with PCOS.Especially,the patients with obesity should be highly vigilant glucose metabolism disorder occurring and should be given positive joint programs treatment for weight control.
ABSTRACT
Objective To investigate the feature of Th1 cytokines induced by Mtb-specific antigen in patients with refractory pulmonary tuberculosis.Methods 28 patients with refractory pulmonary tuberculosis,67 patients with first-treated pulmonary tuberculosis,and 25 healthy controls with positive T.spot (LTBI group) were enrolled.IFN-γ,IL-2 and TNF-α in supernatants from PBMCs stimulated with ESAT-6 and CFP-10 were analyzed with Bender Flowcytomix on flow cytometry.Results The levels of the three cytokines were utmost high in patients with first-treated pulmonary tuberculosis.The lowest level of IFN-γ and IL-2 were induced in patients with refractory pulmonary tuberculosis,and were significantly lower than the LTBI group(Mann-Whitney U ＝ 105.5,162.5,P ＜ 0.01).Conclusions The immunotherapy with IFN-γ and IL-2 may play a role in treatment for refractory pulmonary tuberculosis but not for most of first-treated pulmonary tuberculosis.
ABSTRACT
ObjectiveTo study the role and clinical significance of serum visfatin and retinol binding protein 4 (RBP4) in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss.MethodsThe levels of visfatin and RBP4 were determined by ELISA method in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points ( before and after treatment),and thirty-five patients with other neurologic diseases (20 with sciatica,16 with trigeminal neuralgia) and thirty healthy people were used as control.ResultsThe levels of visfatin and RBP4 in the serum of patients with idiopathic sudden sensorineural hearing loss after treatment [Visfatin (24.26 ± 2.17 ) μg/L; RBP4 (46.65± 5.26 ) mg/L]were markedly higher than the group with other neurologic diseases [Visfatin ( 20.67 ± 2.14 ) μ g/L; RBP4(34.37 ±5.73)mg/L] and the healthy control group[Visfatin(17.61 ±2.45) μg/L; RBP4 (24.82 ±5.24)mg/L] ( t =10.38,10.41,12.16,15.06,P ＜0.01),and it was significantly less than that before treatment [Visfatin(32.24 ± 2.37) μ /L; RBP4 ( 57.43 ± 6.19 ) mg/L] ( t =17.25,15.12,P ＜ 0.01 ).The levels visfatin and RBP4 in serum of severe group with idiopathic sudden sensorineural hearing loss [Visfatin ( 36.52 ± 2.46 ) μg/L; RBP4 (67.17 ± 5.92 ) mg/L] were markedly higher than those in the moderate group[Visfatin(28.92 ±2.26)μg/L; RBP4 (55.34±5.95)mg/L]( t =11.21,11.17,P ＜0.01).The levels visfatin and RBP4 in serum of moderate group were markedly higher than those in the mild group [Visfatin ( 25.31 ± 2.32 ) μg/L; RBP4 ( 47.48 ± 5.82 ) mg/L],all these differences were statistically significant( t =10.43,10.49,P ＜0.01 ).There was a positive correlation between visfatin and RBP4 in patients with idiopathic sudden sensorineural hearing loss ( r =0.68,P ＜ 0.01 ).ConclusionsThe levels of serum visfatin and RBP4 have instructive significance in idiopathic sudden sensorineural hearing loss treatingand prognosis estimating