Frequência de hipovitaminose D em mulheres adultas / Frequency of hipovitaminose D in adult women

Objetivo ­ Verificar níveis séricos de vitamina D em mulheres adultas através da análise de seus exames laboratoriais. Métodos ­ Estudo retrospectivo de 30 prontuários de pacientes subdivididos em dois grupos (Grupo A ­ 20 a 40 anos) e (Grupo B ­ 41 a 59 anos) que estiveram em consulta endocrinológica no período de janeiro de 2015 a janeiro de 2016. Resultados ­ Observa-se maior frequência de hipovitaminose D, 27% no grupo com idade de 41 a 59 anos, sendo que insuficiência de vitamina D apresenta o mesmo percentual (40%) em ambos os grupos. Os valores de normalidade ficou abaixo de (50%) nas pacientes avaliadas. Conclusão ­ Os resultados obtidos indicam que o total da população estudada apresentou níveis de vitamina D abaixo da normalidade. Portanto torna-se necessário a triagem da deficiência dessa vitamina extensivo a demais grupos populacionais, informando a sua prescrição em campanha de saúde pública

Objective ­ To verify serum levels of vitamin D in adult women through the analysis of their laboratory tests. Methods ­ Retrospective study of 30 patient charts subdivided into two groups (Group A ­ 20 to 40 years old) and (Group B ­ 41 to 59 years old) who underwent endocrinological consultation from January 2015 to January 2016. Results ­ Observations highest frequency of hypovitaminosis D, 27% in the group aged 41 to 59 years, and vitamin D insufficiency presents the same percentage (40%) in both groups. Normal values were below (50%) in the patients evaluated. Conclusion ­ The results indicate that the total population studied had vitamin D levels below normal. Therefore, it is necessary to screen the deficiency of this extensive vitamin to other population groups, informing its prescription in public health campaign

Vitamin D/vitamin D receptor, autophagy and inflammation relevant diseases / 中南大学学报(医学版)

The biological effects mediated by vitamin D and vitamin D receptor (VDR) are involved in the regulation of multiple pathophysiologic processes,including calcium phosphorus metabolism,immune regulation,anti-inflammation,anti-infection and cancer prevention,etc.Autophagy is a eukaryotic cell lysosome-mediated catabolic pathway,which is classified into 3 different types:macroautophagy,microautophagy,and chaperone-mediated autophagy.Since autophagy is vital to maintain energy and metabolism in cells,autophagy dysfunction is closely associated with various pathological processes such as inflammation,infection and tumor.Studies have shown that vitamin D/VDR can affect the different stages of autophagy and regulate inflammation in autophagy.Moreover,vitamin D/VDR and autophagy play an important role in autoimmune disease,diabetes,cardiovascular disease,cancer and other inflammatory diseases.

D vitamin status in Mongolians / Эрүүл мэндийн лаборатори

Vitamin D deficiency is a major health problem worldwide, especially in the elderly, so that an accurate assessment of its prevalence is essential for planning reliable healthcare policy throughout the lifespan. Purpose:The aim of the oncentrationofpresent study wasto assess the25-hydroxyvitamin D 25OHD) across different as well as the mild andmoderate deficiencies ages and genders.Methods:We searched the database of the local Laboratory Information System to retrieve results of 25OHD tests performed on the whole cohort of presumably Mongolian participants aged >22 yrs, who were referred to our laboratory in Gurvan Gal Hospital’s clinical laboratory, a 1-year period (January 2011 - January 2012). Results:Results for 25OHD testing were retrieved for 120 participants. No significant differences between females and males were observed for 25OHD values(20 [4-17.89]ng/ml versus 53 [4-20.06]ng/ml; p=0.3). A non significant variation of 25OHD values was also found by ANOVA analysis throughout 3 age cohorts (22-40, 41-60, >60 yrs), in both genders. In each age group, the values of 25OHD did not significantly differ between genders.Conclusions:We observed a high prevalence of vitamin D deficiency in a Mongolians. Lifestyle factors, including smoking, and physical activity, were significant predictors of serum 25-hydroxyvitamin D concentration.

D vitamin status in Mongolians / Эрүүл мэндийн лаборатори

Vitamin D deficiency is a major health problem worldwide, especially in the elderly, so that an accurate assessment of its prevalence is essential for planning reliable healthcare policy throughout the lifespan. Purpose: The aim of the oncentrationofpresent study wasto assess the25-hydroxyvitamin D 25OHD) across different as well as the mild andmoderate deficiencies ages and genders. Methods: We searched the database of the local Laboratory Information System to retrieve results of 25OHD tests performed on the whole cohort of presumably Mongolian participants aged >22 yrs, who were referred to our laboratory in Gurvan Gal Hospital’s clinical laboratory, a 1-year period (January 2011 - January 2012). Results: Results for 25OHD testing were retrieved for 120 participants. No significant differences between females and males were observed for 25OHD values(20 [4-17.89]ng/ml versus 53 [4-20.06]ng/ml; p=0.3). A non significant variation of 25OHD values was also found by ANOVA analysis throughout 3 age cohorts (22-40, 41-60, >60 yrs), in both genders. In each age group, the values of 25OHD did not significantly differ between genders. Conclusions: We observed a high prevalence of vitamin D deficiency in a Mongolians. Lifestyle factors, including smoking, and physical activity, were significant predictors of serum 25-hydroxyvitamin D concentration.