ABSTRACT
Objective To evaluate the value of plasma soluble urokinase?type plasminogen activator receptor (suPAR)and D?dimer for assessing disease severity and prognosis in patients with traumatic brain injury(TBI). Methods A serial of 112 patients with traumatic brain injury admired to our hospital were divided into mild TBI (GCS score 13~15),moderate TBI(GCS score 9~12)and severe TBI(GCS score 3~8). The levels of plasma suPAR and D?dimer were monitored within 24 h after patient admission. Results The levels of suPAR and D?di?mer in TBI group were obviously higher than those in the control group(15.86±7.33 vs 2.79 ± 0.69,P<0.01;3.50 ± 2.78 vs 24 ± 0.15,P<0.01). The levels of suPAR and D?dimer in the severe TBI group were also obviously high?er than those in the moderate TBI group(P<0.05). Plasma suPAR levels and GCS score had significant negative correlation(r =- 0.854,P < 0.01). D?dimer levels and GCS score showed a negative correlation(r =- 0.738, P < 0.01). Plasma suPAR and D ? dimer was positively correlated(r = 0.753,P < 0.01). The area under the curve of D?dimer(AUC)was larger,0.854,95%CI 0.763~0.945;the AUC of suPAR was 0.801,95%CI 0.698~0.903. Conclusion Higher levels of suPAR and D?dimer in TBI patients is not only relevant to the injury sever?ity ,but also closely to the prognosis.
ABSTRACT
Objective To explore the correlation between cardiac function classification and homocysteine (HCY) ,N-terminal pro-brainnatriureticpeptide(NT-proBNP),fibrinogen(Fbg),D-dimer(D-D) in patients with chronic pulmonary heart disease (CPHD) .Methods A total of 135 cases of CHPD were divided into 4 groups by cardiac function classification of New York Heart Association(NYHA):NYHA class Ⅰ group(group A ,33 cases) ,NYHA class Ⅱ group(group B ,39 cases) ,NYHA class Ⅲ group (group C ,36 cases) ,NYHA class Ⅳ group(group D ,27 cases) .Meanwhile 50 healthy subjects were recruited into HC group .The level of HCY ,NT-proBNP ,Fbg and D-D were detected and compared between different groups .Receiver operating characteristic (ROC) curves were drawn ,the area under ROC curves(AUCs) were calculated to assess the diagnostic value of each item ,the cor-relation between cardiac function classification and HCY ,NT-proBNP ,Fbg ,D-D in CHPD was analyzed .Results Compared with HC group ,the level of HCY ,Fbg and D-D in group A didn′t rose significantly(P>0 .05) .The level of HCY ,NT-proBNP ,Fbg and D-D in group B ,C ,D were significant with those of the control group(P<0 .05) .NT-proBNP increased higher in CHPD as the du-ration of cardiac function classification of NYHA processed (P<0 .05) .The AUCs of HCY ,NT-proBNP ,Fbg ,D-D were respective-ly 0 .710 ,0 .919 ,0 .782 ,0 .864 in CHPD patients .There were significant correlations between cardiac function classification of NY-HA and HCY ,NT-proBNP ,Fbg ,D-D(P< 0 .01) .Conclusion The level of HCY ,NT-proBNP ,Fbg ,D-D could be considered as monitoring and diagnostic indexes of CHPD .
ABSTRACT
Objective To explore the correlation between cardiac function classification and homocysteine (HCY) ,N-terminal pro-brainnatriureticpeptide(NT-proBNP),fibrinogen(Fbg),D-dimer(D-D) in patients with chronic pulmonary heart disease (CPHD) .Methods A total of 135 cases of CHPD were divided into 4 groups by cardiac function classification of New York Heart Association(NYHA):NYHA class Ⅰ group(group A ,33 cases) ,NYHA class Ⅱ group(group B ,39 cases) ,NYHA class Ⅲ group (group C ,36 cases) ,NYHA class Ⅳ group(group D ,27 cases) .Meanwhile 50 healthy subjects were recruited into HC group .The level of HCY ,NT-proBNP ,Fbg and D-D were detected and compared between different groups .Receiver operating characteristic (ROC) curves were drawn ,the area under ROC curves(AUCs) were calculated to assess the diagnostic value of each item ,the cor-relation between cardiac function classification and HCY ,NT-proBNP ,Fbg ,D-D in CHPD was analyzed .Results Compared with HC group ,the level of HCY ,Fbg and D-D in group A didn′t rose significantly(P>0 .05) .The level of HCY ,NT-proBNP ,Fbg and D-D in group B ,C ,D were significant with those of the control group(P<0 .05) .NT-proBNP increased higher in CHPD as the du-ration of cardiac function classification of NYHA processed (P<0 .05) .The AUCs of HCY ,NT-proBNP ,Fbg ,D-D were respective-ly 0 .710 ,0 .919 ,0 .782 ,0 .864 in CHPD patients .There were significant correlations between cardiac function classification of NY-HA and HCY ,NT-proBNP ,Fbg ,D-D(P< 0 .01) .Conclusion The level of HCY ,NT-proBNP ,Fbg ,D-D could be considered as monitoring and diagnostic indexes of CHPD .