ABSTRACT
DDX5 helicase (DEAD box helicases 5), also known as P68, is an important member of an ATP dependent RNA helicase.Studies have shown that DDX5 is abnormally expressed in a variety of cancers, targeting a variety of tumor related signal pathways, regulating upstream and downstream factors to affect the occurrence, invasion and migration of tumor cells. This article describes the biological role of DDX5 in malignant tumors and provides prospects for targeted treatment of tumors.
ABSTRACT
DEAD box family,characterized by the conserved motif D (Asp)-E (Glu)-A (Ala)-D (Asp),are putative RNA helicases,which participate in all cellular processes regulated by RNAs.Studies show that there are examples of dysregulation of DDX family expression in various types of cancer.They are involved in the occurrence and evolution of tumor,and take part in tumor cell proliferation,apoptosis,cycle,invasion,metastasis and metabolism,which can be acted as new molecular markers for the diagnosis of tumor,the evaluation of malignancy and the prediction of clinical prognosis and also provide new potential molecular targets for tumor therapy.Here,we reviewed the structure,biochemical function and the relationship with tumor of DDX family.