ABSTRACT
Introducción: Existe la necesidad imperiosa de individualizar cada tratamiento de diabetes mellitus tipo 2 según situaciones especiales de cada paciente diagnosticado con la enfermedad. Objetivo: Describir el enfoque terapéutico de los pacientes con diabetes tipo 2. Métodos: Se realizó un estudio descriptivo y trasversal en 96 pacientes diagnosticados con diabetes mellitus tipo 2, pertenecientes al policlínico Camilo Torres Restrepo, en el periodo de enero- diciembre 2021. Se estudiaron variables como la edad, sexo, tipo de tratamiento, tratamiento individualizado, control metabólico y adherencia al tratamiento. Se utilizaron técnicas de estadística descriptiva como frecuencia absoluta y porcentaje para variables cualitativas así como medidas de tendencia central para variables cuantitativas. Resultados: Hubo un predominio de las edades más avanzadas (por encima de 60 años) con el 72,9 % de la casuística y del sexo femenino (58,3 %). El 97,0 % de los participantes recibieron tratamiento farmacológico y no farmacológico, el 21,8 % necesitó más de un fármaco. La metformina fue el fármaco más utilizado (37,5 %). El tratamiento de los pacientes diabéticos en situaciones especiales fue inadecuado, excepto en pacientes con sobrepeso y obesidad, los pacientes que tuvieron adherencia al tratamiento, lograron un mejor control metabólico de la enfermedad (48 %). Conclusiones: El enfoque terapéutico en los pacientes estudiados fue inadecuado. El tratamiento de diabetes mellitus tipo 2 debe ser individualizado, desde un fundamento integral de la condición basal de cada paciente, al tener en cuenta sus comorbilidades para lograr una integralidad en las acciones en el nivel primario de prevención.
Introduction: There is an urgent need to individualize each diabetes mellitus type 2 treatment according to the special situations of each patient diagnosed with the disease. Objective: To describe the therapeutic approach of patients with diabetes type 2. Methods : A descriptive and cross-sectional study was carried out in 96 patients diagnosed with diabetes mellitus type 2, belonging to the Camilo Torres Restrepo polyclinic, in the period from January to December 2021. Variables such as age, sex, type of treatment, individualized treatment, metabolic control and adherence to treatment were studied. Descriptive statistical techniques were used, such as absolute frequency and percentage for qualitative variables, as well as measures of central tendency for quantitative variables. Results : There was a predominance of older ages (over 60 years) with 72.9 % of the casuistry and females (58.3 %). 97.0 % of the participants received pharmacological and non-pharmacological treatment, and 21.8% required more than one drug. Metformin was the most used drug (37.5 %). Treatment of diabetic patients in special situations was inadequate, except in overweight and obese patients, and patients who adhered to treatment achieved better metabolic control of the disease (48%). Conclusions : The therapeutic approach in the studied patients was inadequate. The treatment of diabetes mellitus type 2 must be individualized, from a comprehensive basis of the baseline condition of each patient, taking into account their comorbidities to achieve comprehensive actions at the primary level of prevention.
ABSTRACT
Objective To evaluate the effects of sitagliptin on blood glucose,blood pressure,blood lip and carotid artery intima media thickness (IMT) in metabolic syndrome patients with type 2 diabetes.Methods The clinical data were collected for 64 cases of inpatient and outpatient patients with metabolic syndrome with type 2 diabetes.Those patients included anti-diabetes native patients and patients only used the stable metformin dose.After signed off the informed consent form,those patients were randomized to the sitagliptin treatment group or original treatment group,and the metabolic index and carotid artery intima-media thickness were evaluated after 24 weeks treatment.Results The body mass index (BMI),waist circumference (WC),fasting plasma glucose (FPG),triglycerides (TG),high density lipoprotein cholesterol (HDL-C),systolic blood pressure (SBP),diastolic blood pressure (DBP),glycated hemoglobin a1c (HbA1c),and carotid artery IMT in two groups were comparable at baseline.After 12 weeks treatment,the FPG,TG,DBP,and HbA1c in the sitagliptin group were significantly better than original treatment group and the baseline,while there was no different between two groups in other index.After 24 weeks treatment,the FPG,TG,HDL-C,DBP,HbA1c,and carotid artery IMT in the sitagliptin group were significantly better than original treatment group and the baseline.Conclusions Sitagliptin presents the functions of lowering blood pressure,adjusting blood lipid,and protecting vascular endothelial in addition to lowering blood glucose.
ABSTRACT
Objective To explore the clinical effect of sitagliptin combined insulin compared to those patients whose sugars were not well controlled by insulin alone.Methods The eighty type 2 Diabetes patients whose BMI≥24 kg/m2 and used insulin alone were randomly divided into sitagliptin combined insulin group (40 cases) who were given sitagliptin 100mg/d allied with insulin,an insulin group (40 cases) who were given insulin alone.After 12 weeks,the change of body mass index (BMI),fasting plasma glucose (FPG),2 h postprandial blood glucose (2 h PBG),glycosylated hemoglobin (HbA1 c),β-cell function index(HOMA-β),insulin resistance index (HOMA-IR),insulin quantities,and hypoglycemia rates were observed in two groups.Results Compared with pretherapy,the levels of FPG,2 h BG,HbAlc,HOMA-IR,and hypoglycemia rates were significantly decreased (P ＜0.05) ; BMI was increased in insulin group,while was not increased in sitagliptin combined insulin group.After the treatment,the insulin quantities were decreased in the combined group while increased in the control group (P ＜ 0.05).Conclusions Sitagliptin combined insulin can effectively control glucose levels of type 2 diabetes patients,decrease the insulin quantities and the risk of hypoglycemia,and does not increase the weight.