ABSTRACT
DNAzymes, screened through in vitro selection, were artificial nucleic acids with catalytic function . They could cleave specific substrates in the presence of cofactors with unique characteristics, such as high catalytic activity, high specificity for cofactors, excellent stability, and easy to synthesize and modify. The combination of DNAzymes with nanomaterials could retain the DNAzyme activity and realize the functional integration of recognition and signal transduction, promoting rapid development of biosensors. In the current paper, we mainly reviewed the recent progress in DNAzyme-nanomaterial based biosensors, and the nanomaterials included gold nanoparticles, graphene, quantum dots, magnetic nanomaterials, and so on.
ABSTRACT
DNAzymes generated by in vitro selection are single-stranded DNA molecules with catalytic capabilities. This article introduced the DNAzyme in such spects as structures, modifications, designing strategies, catalytic traits, advantages as well as its application as a new tool of gene therapy of tumor.