ABSTRACT
Double negative T cell is a rare type of cells that regulates immune responses in a way that is unique.In the process of adoptive immunotherapy,it gradually becomes a hot spot,because of its obvious anti-tumor effect.However,the mechanism by which DNT cell kills tumor cell is not clear.Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) and natural-killer group 2,member D (NKG2D) pathway is a more important part of its killing mechanism,and NKG2D receptor can also regulate the production of soluble TRAIL,making the two channels to establish a certain link.In this paper,the effect of Double negative T cell and the mechanism of TRAIL and NKG2D pathway in DNT cell's anticancer were described.
ABSTRACT
NKG2D is an activating receptor expressed on various immune cells' surfaces.Currently,eight ligands have been found,they can be divided into two kinds:MHC Ⅰ related protein and ULBP molecules.NKG2D receptors and their respective ligands differentially exist in normal and cancerous tissues.So far,many researchers have found that a lot of immune cells' anti-tumor mechanism is mediated by NKG2D receptor and it can't be replaced in the resistance to the development of carcinoma.adoptive immunotherapy is a new method of treating cancer that propose to find tumor-specific cytotoxicity immune cells and enlarge the amount of it,then injected into human body to resist tumor.Recently,many researchers have found that DNT cells (CD4-CD8-T 细胞)have the function of anti-tumor;sadly its mechanisms are unclear.After the summary of NKG2D receptor-mediated pathway of destruction,this paper try to analyze its relevance to DNT cells' killing effect,on the purpose of finding the Killing mechanism of DNT cells that may existed.