ABSTRACT
Resumen Se diseñó y realizó el análisis psicométrico de un instrumento para evaluar duelo patológico en adultos. El estudio es de tipo instrumental, los participantes fueron 235 hombres y mujeres mayores de 18 años. La validación de contenido se realizó con 8 jueces expertos en el tema y en psicometría, para la validez de constructo se realizó un análisis factorial exploratorio. Los ítems se agruparon en cuatro (4) factores que explican el 64.64% de la varianza. En el análisis bajo la teoría de respuesta al ítem (TRI), se encontró que el INFIT de los ítems o estadígrafo de ajuste que captura respuestas no esperadas, cerca del nivel de habilidad del evaluado osciló entre 0.6 y 1.19 y el OUTFIT estadígrafo que captura anomalías lejos de las habilidades calibradas para los evaluados, osciló entre .34 y 1.20, resultados que indican que la prueba cumple con los requerimientos psicométricos exigidos para este tipo de instrumentos. El instrumento aporta a la psicología, puesto que puede ser usado como una medida válida, fiable y útil para el objetivo y contexto para el cual fue elaborado.
Abstract We designed and analyzed an instrument to measure pathological grief in adults with 235 participants. Eight experts in grief and psychometry participated in the content validity phase, and an exploratory factor analysis was performed to assess construct validity. Items were grouped in four factors explaining 64.64% of the variance. The IRT analysis found an infit between 0.6 and 1.19 and the outfit between 0.34 and 1.20. The test fulfills the required psychometric indicators.
ABSTRACT
Aim To investigate the changes of serum metabolism after the treatment of DOA and DOO on myocardial ischemia reperfusion ( MI/R ) injury in rats, and to explore the pathogenesis of MI/R injury and drug action mechanism. Method The serum samples of Sham group, Model group, DOA group and DOO group of rats were acquired, gas phase time of flight mass spectrometry ( GC-TOF-MS) was applied to analyze the metabolic profiles of the samples. After da-ta preprocessing, they were processed into SIMCA 14. 1 software for multivariate statistical analysis. Results By principal components analysis ( PCA ) , partial least squares analysis ( PLS-DA) and orthogonal partial least squares analysis ( OPLS-DA ) , the Model group and Sham group were obviously separated, the drug in-tervention group and Model group were separated and close to Sham group. The therapeutic effect of DOO and DOA on MI/R injury in rats was proved. The ex-perimental results identified 13 endogenous biomark-ers, which were related to the glucose metabolism,lipid metabolism and amino acid metabolism pathway. Con-clusion DOA and DOO may protect the MI/R injured rats by regulating the glucose metabolism, lipid metab-olism and amino acid metabolism pathway.
ABSTRACT
Kim Doo-jong, the founder of the history of medicine in Korea, was born on 2nd March, 1896. After finishing his primary education in his home town, he went to Seoul to receive a higher education. He entered Keijo Medical College in 1918. However, at the end of his first year, he participated in the 3 . 1 movement which protested against Japanese harsh rule over Korea. On account of his participation in the movement, he was forced to leave the college which was run by the Japanese colonial government. Then he went to Japan to enter Kyoto Municipal Medical College, from which college he graduated in 1924. After the graduation, he went to Beijing to work in a hospital run by Japanese. Having felt uncomfortable about the situation in Beijing, he moved to Manchuria, where he opened his private clinic and saw patients for 7 years. As the life as a clinician did not satisfy him, he gave up his practice, and determined to devote himself to the study of history of medicine. He was 43 years old when he started studying history of medicine at the Dong Ah Institute, an affiliated research institute of Manchuria Medical College founded by Japanese. The institute had a large and magnificent collection of ancient texts of oriental medicine. He set on historical studies on the oriental medicine from the perspective of the Western medicine. His doctorial dissertation was about anatomy in oriental medicine. He intended to continue his study on organology, myology, etc., but the sudden end of the World War II made him return to Korea. This meant that he could not make access to the large collection of the institute, and his themes of the research had to be changed. On returning to Korea, he established the Department of the History of Medicine in Seoul National University, which was the only and the first one of its kind. He wrote History of Korean Medicine, which still remains one of the most important works on the history of Korean medicine. He was very energetic and active in his academic activities even during his late years. He passed away on 18th May 1988 at the age of 92.