ABSTRACT
Objective To explore the clinical efficacy of Danzhi Xiaoyao capsule combined with leuprolide acetate for treatment of central precocious puberty(CPP) in children.Methods One hundred and six female children with CPP in Xinyang Central Hospital from March 2015 to December 2016 were selected and divided into control group and observation group by random digits table,with 53 children in each group.The children in the control group were given leuprolide acetate subcutaneously;based on this,the children in the observation group were given Danzhi Xiaoyao capsule.After treatment,the ovarian volume,uterine volume,bone age index,sex hormone,height change,clinical efficacy and adverse reactions of children were compared between the two groups.Results Before treatment,there was no statistic difference in the ovarian volume,uterine volume and bone age index of children between the two groups (P ＞ 0.05);the ovarian volume,uterine volume and bone age index of children in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05);the ovarian volume,uterine volume and bone age index of children in the observation group were significantly lower than those in the control group (P ＜ 0.05).Before treatment,there was no statistic difference in the luteotropic hormone (LH),follicle-stimulating hormone (FSH) and estradiol(E2) levels of children between the two groups (P ＞ 0.05);the LH,FSH and E2 levels of children in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05);the LH,FSH and E2 levels of children in the observation group were significantly lower than those in the control group (P ＜ 0.05).The height growth speed of children in observation group [(4.52 + 0.83) cm · a-1] was significantly lower than that in control group [(7.35 ± 1.02) cm · a-1] (P ＜ 0.05).The total effective rate of children in observation group (92.45％) was significantly higher than that of control group (73.58％) (x2 =6.692,P ＜ 0.05).There was no adverse effects in the two groups during treatment.Conclusion Danzhi Xiaoyao capsule combined with leuprolide acetate for treatment of central precocious puberty in children has evident effect,less adverse reactions;it can effectively regulate the sex hormones levels of body,and delay the growth time.
ABSTRACT
?AIM: To evaluate the clinical effects, corneal surface shape and corneal thickness variation after treated by Danzhi Xiaoyao Capsule combined with hypromellose 2910, dextran 70 and glycerol eye drops for dry eye in menopausal patients.?METHODS: Eighty menopausal patients ( 160 eyes ) diagnosed as dry eye were randomly divided into groups A and B ( 40 patients each ) . Group A was treated with hypromellose 2910,dextran 70 and glycerol eye drops only and group B was treated with Danzhi Xiaoyao Capsule and eye drops. Before and 1mo after treatment, the clinical effects were evaluated by symptom scores, fluorescein staining ( FL ) , tear film breakup time ( BUT ) and Schirmer Ⅰ test. While the corneal surface regularity index (SRI), surface asymmetry index (SAI) and central corneal thickness ( CCT) were observed.? RESULTS: At 1mo after treatment, the symptoms scores and FL scores of the 2 groups decreased significantly( P0. 05).?CONCLUSION: Combination therapy of Danzhi Xiaoyao Capsule and hypromellose 2910, dextran 70 and glycerol eye drops for menopausal patients with dry eye is more effective than single eye drops, and can improve the symptoms and signs.