Clinical Features and Serum Dehydroepiandrosterone Sulfate and Total Testosterone Levels in Female Patients with Androgenetic Alopecia / 대한피부과학회지

BACKGROUND: The development of androgenetic alopecia is thought to be caused by increased androgen action on the hair follicles in the genetically predisposed person. Although most reports about dehydroepiandrosterone sulfate(DHEA-S) and total testosterone in female androgenetic patients are within normal limits, there are some controversies about comparing the mean values of the patients with those of the normal control group. OBJECTIVE: The purpose of this study was to compare the mean value of plasma DHEA-S and total testosterone of the patients with those of normal controls according to their ages, and evaluate relations between hormone levels and clinical type and hyperandrogenic symptoms(HAS). METHOD: We examined 60 female patients with androgenetic alopecia for clinical types, symptoms, family histories, and other systemic diseases. The mean value of the patients were compared with those of 42 normal controls according to ages, clinical types, and HAS. RESULTS: 1. Forty two cases(70.0%) were Ludwig type I, 16 cases(26.7%) were type II, 2 cases(3.3%) were type III. 26 cases(43.3%) were between 20-29 years, 19 cases(31.7%) were between 30-39 years. 2. Common age of onset was between 20-29years(23 cases, 38.3%) and below 19 years old(21 cases, 35.0%). 3. There were 32 cases(53.3%) who showed HAS and seborrhea was the most common symptom (20 cases). 4. There were 33 cases(55.0%) who showed a family history and the father was the most common relative(19 cases). Family history of first degree relative was 31 cases(51.7%). 5. Plasma DHEA-S levels of both patients and control group were all within normal limits, and there were no significant differences in the mean values between the patients ( 1633.03+/-736.31 ng/ml) and normal controls(1764.72+/-690.94 ng/ml). There were also no difference between the patients and controls according to their ages. 6. In total testosterone, 7 out of 60 patients and 3 out of 42 normal controls were beyond the normal limit and there were no significant differences in the mean values between the patients(0.548+/-0.386 ng/ml) and normal controls(0.563+/-0.501 ng/ml). There were also no differences between the patients and controls according to their ages. 7. There was no significant difference in the mean value of DHEA-S and total testosterone among type I, types II & III, and normal controls. 8. There was no significant difference in the mean value of DHEA-S and total testosterone among patients with HAS, without HAS, and normal controls. CONCLUSION: There were no significant differences in the mean values of plasma DHEA-S and total testosterone between the patients and normal controls and no significant differences in the mean values of hormone levels according to clinical type and HAS.

Relationship between the concentration of fetal total bile acid and fetal adrenocortical dysfunction in intrahepatic cholestasis of pregnancy / 中华围产医学杂志

Objective To evaluate the association of fetal total bile acid (TBA) concentration with fetal adrenocortical dysfunction in intrahepatic cholestasis of pregnancy(ICP). Methods The concentration of TBA, cortisol and DHEA-S in the cord blood were measured in 20 fetuses with maternal ICP (ICP group) and 22 fetuses of normogravidas (control group) after elective cesarean section. The cord blood TBA concentration was investigated by enzyme method and the cord concentration of cortisol and DHEA-S by radioimmunoassay. Results The cord TBA concentration in ICP group was significantly higher than that of controls [(8.93?3.16)mmol/L vs (4.33?1.51)mmol/L, P0.05)]. The cord blood level of cortisol,DHEA-S and the ratio of DHEA-S over cortisol were correlated with the cord blood TBA concentration (r 1= 0.87,r 2=-0.88,r 3=-0.84,P

Plasma Levels of Dehydroepiandrosterone Sulfate ( DHEA - S ) and Total Testosterone in the Patients with Female androgenetic Alopecia / 대한피부과학회지

BACKGROUND: It has been known that androgenetic alopecia in both male and female is due to the role of the androgen hormone in the hair follicle, but the level of the androgen hormone in the plasma is controversial in relation with the development of the alopecia. OBJECTIVE: We have tried the clarify if there is any or no difference in the plasma levels of the hormones between the normal female and the patient with alopecia, because the range of the plasma DHEA-S and total testosterone in the normal female is very wide. METHODS: Plasma levels if the hormones were examined in 22 patients with female androgenetic alopecia and 20 normal females. RESULTS: 1. In DHEA-S, 21(95.5%) aut of 22 female androgenetic alopecia patients were in the normal range while 20(100%) of the 20 normal females were all within the normal range. However the mean value of the hormone(88.89+101.41 g/dl) in the patient group was significantly higher than that(82.18+44.03 g/dl) of the normal group(p<0.05). 2. In total testosterone, 17(94.4%) out of the 18 patents were in the normal range while 20 (100%) of 20 normal females were all within the normal range. However the mean value of the hormone(0.22+0.20ng/ml) in the patient group was significantly higher than that(0.08+0.09ng/ml) of the normal group(p<0.05). 3. As for distribution of DIEA S according to the age, the value of the patient group was higher than that of the normal group in all age groups studied. In the distribution of total testosterone according to age, there was no difference between the normal and the patient in the twenties. After the twenties, the testosterone levels were higher in the patients than the normal females. CONCLUSION: There were significant differences in mean values of plasma DHEA-S and total testosterone between the patients and the normal females although individuals in both groups were largely wit,hin normal range of the hormones.

A Study on Plasma Levels of Testosterone and Dehydroepiandrosterone - sulfate ( DHEA - S ) in the Patients with Acne Vulgaris / 대한피부과학회지

This study was performed to detect the hormonal abnormalities and to investigate the relationship between the levels of plasma testosterone and DHEA-S in 21 female patients with acne vulgaris using radioimmunoassay. The results were as follows : 1. The levels of plasma testosterone in patients group and control group(n=9) were 352+/-11.8 ng/dl, 223+/-9.7 ng/dl, respectively, and significantly elevated in patient group(p < 0.01), 2. The levels of plasma DHEA-S in patient group and control group were 286.6+/-126.8 pg/dl, 238.6+/-60.0 pg/dl, respectively, and did not show statistical significance. 3. The levels of plasma testosterones in patient subgroups classified by modified Pillsbury method were as follows minor group 32.6+5.3 ng/dl, mild group 33.4+/-15,5 ng/dl, moderate group 39.6+/-12.6 ng/dl. The testosterone levels in all the subgroups increased significantly than those in control group(352-t11.8 ng/dl) (p<0.05, p<0.05 p < 0.01) 4. The levels of plasrna DHEA-S in patient subgroups were follows minor group 242.5+/-412 pg/dl, mild group 263.9+/-166.1 pg/dl, moderate group 353.4+/-1273 pg/dl. The DE3EA-S levels in moderate group increased significantly than those in cotrol (238,6+/-60,0 pg/dl) and minor group(p<0.05). 5. There was no correlation between the plasma testosterone levels and the plasma DHEA-S levels in the acne patients.