ABSTRACT
Lipid-based nanocarrier is a classic drug delivery system with great biocompatibility and biodegradability. It can effectively reduce the toxicity of anti-tumor and anti-infective drugs in clinical practice. However, it has not yet met the clinical demand for enhanced therapeutic efficacy, and the clinical application is still very limited. The complex in vivo delivery process of lipid-based nanomedicine and the reciprocal interactions with body lead to unexpected changes in in vivo performance of nanomedicine and seriously hinder clinical translation. Therefore, the in-depth study of the relationships among intrinsic properties of lipid-based nanomedicine, the in vivo delivery process, and the regulatory mechanisms will not only provide guidance for the rational design of nanocarriers, but also promote the clinical translation and precision medicine of new lipid-based nanomedicine. In this review, we summarize the in vivo delivery process, regulating factors and intervention strategies for the in vivo delivery of lipid-based nanomedicine.
ABSTRACT
@#Occupational Therapy (OT) can help enhance human performance and well-being through assistive technology (AT). This entails guiding clients through the AT selection and acquisition process down to helping them integrate these tools’ use as supports to their day-to-day living. Unfortunately, the AT prescription and acquisition process can be tedious, costly, complicated, and uncoordinated in some countries such as the Philippines. AT service delivery is an undeveloped area of practice among Filipino occupational therapists due to the lack of local evidence-based research, practice models, and practical knowledge of the process. Moreover, access to AT is affected by economic factors and by some Filipinos’ negative attitudes towards assistive devices as being a validation of one’s incapacitation. The SAKLAY is a service delivery framework that was created to offer a practical and systematic guide to Filipino occupational therapists who render AT services for persons with disabilities (PWD) that takes into account the client’s needs, resources, abilities, and contexts.
Subject(s)
Occupational Therapy , Self-Help Devices , PhilippinesABSTRACT
Objective To discuss the effect of inhaling laughing gas and epidural anesthesia on reducing and relieving labor pain,and their influence on delivery process,mode and on newborns.Methods 190 cases were divided into three groups,group A: inhaling laughing gas group,group B:epidural anesthesia(CSEA) group and group C:without any analgesia,as control group. Observation and studing the degree of labor pain,delivery process,delivery ways,Apgar score,hemorrhage volume of delivery period,rate of postpartum hemorrhage among the three groups.Results Both the two kinds of analgesic methods(group A and group B) were effective in relieving labor pain.The method of inhaling laughing gas shorted the delivery process(P