ABSTRACT
Objective: To compare the effects of Jiaoai Decoction and Siwu Decoction on hemorheology, blood coagulation function, and platelet aggregation in acute blood stasis rats, and reveal that Jiaoai Decoction evolved into Siwu Decoction could increase the efficacy of activating blood circulation and dissipating blood stasis. Methods: Ice water bath and sc injection of adrenaline were both used to establish the acute blood stasis rat model. The whole blood viscosity (WBV), plasma viscosity (PV), haematocrit (HCT), thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), plasma fibrinogen (FIB), and platelet aggregation (PAG) were detected to observe the effects of Jiaoai Decoction and Siwu Decoction on the acute blood stasis rat model. Results: Compared with the normal control group, the model group could significantly increase hemorheological indices (P < 0.01), shorten TT, PT, and APTT (P < 0.01), and increase the FIB content (P < 0.01) and platelet aggregation (P < 0.01). Compared with the model group, Siwu Decoction could significantly decrease WBV, PV, and HCT (P < 0.05, 0.01), prolong TT, APTT, and PT (P < 0.05), and reduce the content of FIB (P < 0.01) and platelet aggregation (P < 0.01). The mid-dose Jiaoai Decoction could significantly decrease WBV in 1 s-1 and HCT (P < 0.05, 0.01), prolong APTT (P < 0.05) and shorten PT (P < 0.01), and reduce the platelet aggregation (P < 0.01). Compared with mid-dose Jiaoai Decoction, Siwu Decoction could significantly prolong the TT (P < 0.01). Conclusion: Jiaoai Decoction evolved into Siwu Decoction could increase the efficacy of activating blood circulation and dissipating blood stasis. Meanwhile, the study reveals the scientific evidence for Jiaoai Decoction and Siwu Decoction in clinical application.