ABSTRACT
El dermatomiofibroma es un tumor benigno infre-cuente de origen mesenquimático. Generalmente, se presenta como un tumor rosado nodular, espe-cialmente en mujeres en la década de los 30, en hombros y axila. Clínica e histológicamente puede simular otros tu-mores mesenquimáticos como el dermatofibroma , leiomioma y el dermatofibrosarcoma protuberans. Se presenta caso de dermatomiofibroma lineal, para describir sus características clínicas e histo-lógicas, necesarias para su correcto diagnóstico y enfrentamiento terapéutico.
Dermatomyofibroma is an uncommon mesen-chymal benign tumor. It usually presents in wo-men at their thirties, as a pink nodular tumor on the shoulder and axilla. Clinically and histologically it may mimic other mesenchymal tumors such as dermatofibroma, leiomyoma and dermatofibrosarcoma protube-rans. We present the case of a linear dermatomyofi-broma and describe its clinical and histological characteristics, which may help the clinician in the correct diagnosis and therapeutic approach of this rare but benign tumor.
Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Histiocytoma, Benign Fibrous/diagnosis , Histiocytoma, Benign Fibrous/pathology , Leiomyoma/diagnosis , Leiomyoma/pathologyABSTRACT
Dermatomyofibroma is a benign and rare proliferation of myofibroblasts and fibroblasts of the skin.Dermatomyofibroma commonly locates at the shoulder and neck of young adults and adolescents.Other frequently affected anatomic sites are upper arms,thigh,chest wall,back,axillary region and abdomen.Herein,we reported a case of dermatomyofibroma occurred in the nasion.The asymptomatic firm nodule and histopathological features were consistent with dermatomyofibroma.Immunohistochemically,the tumor cells expressed vimentin,HHF35 and α-smooth muscle actin (α-SMA).The patient was followed up for 2 years after excision of the tumors and recurrences were not observed.
ABSTRACT
Dermatomyofibroma is a rare benign cutaneous mesenchymal neoplasm of the fibroblasts and myofibroblasts. The majority of dermatomyofibromas present as red-brown discolored plaques or nodules, commonly located on the shoulder, upper arm, axilla, neck, and/or upper trunk. These lesions develop most frequently in young female patients at a mean of 28-years-of-age. Herein, a case of dermatomyofibroma is reported that developed in an infant. A 4-month-old boy presented with an ill-defined bluish firm plaque on the trunk that developed 1 month after birth. Histopathologically, there was proliferation of bland-looking spindle cells with fascicular arrangement in the dermis and subcutaneous tissue. Immunohistochemistry showed that most of the tumor cells expressed diffuse positivity for vimentin and smooth muscle actin, but were negative for S-100 protein, desmin, and CD34.
Subject(s)
Female , Humans , Infant , Male , Actins , Arm , Axilla , Dermis , Desmin , Fibroblasts , Immunohistochemistry , Muscle, Smooth , Myofibroblasts , Neck , Parturition , S100 Proteins , Shoulder , Subcutaneous Tissue , VimentinABSTRACT
Dermatomyofibroma represents a recently-described, relatively rare, distinct cutaneous mesenchymal neoplasm, which shows a myofibroblastic line of differentiation. It presents as a solitary, slow-growing, nodular or plaque-like lesion, and commonly occurs on the shoulder and axilla area of young female patients. Histopathologically, the tumor is a non-encapsulated, plaque-like lesion, composed of fascicles of monomorphic spindle cells predominantly oriented parallel to the skin surface. We report a 21-year-old female with a solitary nodule on the shoulder, which showed histological and immunohistochemical features diagnostic of dermatomyofibroma.
Subject(s)
Female , Humans , Young Adult , Axilla , Myofibroblasts , Shoulder , SkinABSTRACT
Dermatomyofibroma is a rare benign dermal tumor, mainly found in young women. Clinically it can be confused with keloid or dermatofibrosarcoma protuberans. Typical histopathologic features of dermatomyofibroma are sufficiently distinctive to alert histopathologists to consider dermatomyofibroma in the diagnostic process. We report a case of dermatomyofibroma, presenting as reddish plaques and nodules on the buttock of a 2-year-old boy. Histopathologic examination showed fascicles of uniform spindle cells in the reticular dermis, predominantly oriented parallel to the epidermal surface. Immunohistochemical study and electron microscopy confirmed its myofibroblastic nature.
Subject(s)
Child , Child, Preschool , Female , Humans , Male , Buttocks , Dermatofibrosarcoma , Dermis , Keloid , Microscopy, Electron , MyofibroblastsABSTRACT
Dermatomyofibroma is a recently described, benign acquired plaque-like cutaneous proliferation of fibroblast and myofibroblast. Clinically, it is located in or around the shoulder and measures from 1 to 2 cm in greatest diameter. Histologically, these are non-encapsulated but well-circumscribed, plaque-like lesions located in the reticular dermis, and composed of fascicles of monomorphic myofibroblasts, oriented parallel to the skin surface. We report a 25-year-old man with a 1.5X1.5 cm sized skin colored plaque-like mass on his left shoulder and showed the histologic finding of dermatomyofibroma.
Subject(s)
Adult , Humans , Dermis , Fibroblasts , Myofibroblasts , Shoulder , SkinABSTRACT
Dermatomyofibroma, first described by Kamino et al in 1992, is a rare plaque-like proliferation of fibroblasts and myofibroblasts of the skin. The lesion is a solitary plaque resembling a keloid or scar and is usually located on the shoulder and axilla. Histologically, the lesion is characterized by a proliferation of uniform spindle-shaped cells arranged as fascicles with a parallel arrangement to the skin surface. We report a case of dermatomyofibroma in a 47-year-old woman who had multiple, red papules and plaques on the left upper arm, left hand and right foot. The biopsy specimen obtained from the lesion of left upper arm showed fascicles of proliferations of uniform spindle-shaped cells and thin collagen fibers in the upper half of the dermis, which were arranged parallelly to the skin surface. Immunohistochemically, spindle-shaped cells stained positively for vimentin and smooth muscle actin, but were unstained for Keratin, S-100 protein, Factor VIII-R Ag and desmin.