ABSTRACT
La intoxicación por sulfato ferroso es importante en niños, provoca lesiones graves en diferentes órganos, incluso la muerte si no se trata inmediatamente, es importante mencionar que los daños ocasionados estarán en relación con la cantidad ingerida. El diagnostico se realiza principalmente con la clínica y laboratorio el cual indicara valores anormales de hierro en sangre, el tratamiento rápido con Desferoxamina, permite la fácil eliminación de hierro. La intoxicación por sulfato ferroso debe ser atendida rápida e inmediatamente, saber que hacer puede ayudar en mucho al paciente y se puede evitar las complicaciones. Se presenta el caso de un niño de 1 año con un cuadro clínico de aproximadamente 2 horas caracterizado por vómitos en varias oportunidades de color café, alteración de conciencia, posterior a la ingesta de aproximadamente 40 tabletas de sulfato ferroso. Es referido del centro de salud Sumun Paya al servicio de emergencias del Hospital pediátrico Manuel AsencioVillarroel por presentar intoxicación por sulfato ferroso, a quien se le manejo inmediatamente realizándole un lavado gástrico.
The intoxication for ferrous sulfate is important in children; it causes grievous bodily harm in different organs, even the death if it is not immediately, it is important to mention that the caused damages will be in connection with the ingested quantity. He diagnoses he/she is carried out mainly with the clinic and laboratory which indicated abnormal securities of iron in blood, the quick treatment with Desferoxamina, it allows the easy iron elimination. The intoxication for ferrous sulfate should be assisted quick and immediately, to know that to make can help in a lot to the patient and you can avoid the complications. The case of a 1 year-old boy is presented with a clinical square of approximately 2 hours characterized by vomits in several opportunities of brown color, conscientious alteration, later to the ingesta of approximately 40 ferrous sulfate pills. It is referred of the center of health Sumun Paya to the service of emergencies of the pediatric Hospital Manuel AsencioVillarroel to present intoxication for ferrous sulfate, to who is managed carrying out him a gastric laundry immediately.
ABSTRACT
One of the most deleterious consequences of iron overload in thalassemia is the presence of non-transferrin bound iron (NTBI), a free radical that acts as a catalyst for free oxygen radicals, in particular for hydroxyl free radicals (OH.). These radicals oxidize both membrane lipids and proteins causing irreversible damage to biologically important molecules and cellular structures. Treatment with iron chelators has been important to improve survival of these individuals. The aim of this work was the study on the effects of deferoxamine (DFO) and deferiprone (DFP) on erythrocytes under the pro-oxidative action of TBHP isolated from normal individuals and patients with β-thalassemia. The in vitro action of deferoxamine and deferiprone on the oxidative metabolism of erythrocytes from β-thalassemic patients treated at the Centro de Hematologia e Hemoterapia do Paraná (HEMEPAR), Brazil, under the pro-oxidative action of TBHP was studied. Methemoglobin concentrations, reduced glutathione (GSH), hemolysis indexes and the enzyme activities of G6-PD and GR were determined. The oxidation indexes were higher in erythrocytes of β-thalassemic individuals than those from normal individuals. Treatment of the normal and β-thalassemic erythrocytes with DFO and/or DFP protected against the formation of GSH promoted by TBHP.
Uma das maiores consequências da sobrecarga do ferro na β-talassemia é a presença de ferro não ligado à transferrina (NTBI), um radical livre que age como um catalisador do radical livre do oxigênio, particularmente radical hidroxil (OH.). Estes radicais oxidam os lipídeos e as proteínas da membrana causando danos irreversíveis às moléculas biologicamente importantes e às estruturas celulares. O tratamento com quelantes do ferro é importante para a melhoria da sobrevivência destes indivíduos. O objetivo deste trabalho foi o estudo sobre o efeito da desferoxamina (DFO) e da deferiprona (DFP) em eritrócitos isolados de indivíduos normais e de pacientes com β-talassemias, sob a ação pró-oxidativa de TBHP. Neste trabalho foi estudada a ação in vitro da desferoxamina e o deferiprona no metabolismo oxidativo dos eritrócitos de pacientes β-talassêmicos atendidos no Centro de Hematologia e Hemoterapia do Paraná (Hemepar), Brasil, sob a ação pró-oxidativa de TBHP. Concentrações de metahemoglobina glutationa reduzida, índices de hemólises, atividades das enzimas G6PD e GR foram determinadas. Os índices de oxidação analisados foram maiores nos eritrócitos de indivíduos β-talassêmicos do que nos normais. Tratamentos dos eritrócitos normais e β-talassêmicos com DFO e/ou DFP protegem contra a oxidação de GSH promovida por TBHP.