ABSTRACT
Optimization of Traditional Chinese Medicine (TCM) clinical trials as philosophy, process and method, is extremely necessary and can be applied in different levels. Optimization of TCM clinical trials should follow some principles and procedures, and be executed in two ways. Optimization of treatment plan should be supported by the research basis and literature experience, and be perfected by research group and experts argumentation. Optimization of design plan is modified and accomplished by expert discussion and repeated consulting multi-disciplinary experts. Specific research objective, exact target population definition, proper design plan selection, valid calculation of sample size, precise and appropriate main outcome measures, data management system, medical ethics and statistical analysis are the focuses.
ABSTRACT
OBJECTIVE:To improve the proposal put forward by a hospital on the pharmacoeconomic evaluation of community-acquired pneumonia.METHODS:The domestic pharmacoeconomic evaluation papers on the community-acquired pneumonia were evaluated.The problems lie in the proposal put forward by a hospital on the pharmacoeconomic evaluation of community-acquired pneumonia were analyzed and the measures for its improvement were put forward.RESULTS:The proposal had problems in research angle,determination of sample size,cost calculation,determination of quality of life etc.CONCLUSION:Measures for the improvement of the proposal should be put forward from the aspects of model construction,sample size determination,the design of quality of life table and sensitivity analysis.