ABSTRACT
This article describes the developing process of China’s pathogenic microorganism laboratory construction through a fair summary of the key points and events involving the issues of "Pathogenic Microbiology Laboratory Biosafety Management Regulations" , "National High Level Biosafety Laboratory System Construction Plan "and "High Level Biosafety Laboratory System Construction Plan" (2016-2025) " , the research and development of Domestic Mobile Biological Safety Level-3 Lab, the establishment and operation of Wuhan National Biosafety Laboratory and the release of other key technology and equipment development.
ABSTRACT
123 children with Kashin- Beck disease (KBD) and 84 normal children at the age of 2-13 in the KBD-affecter area have been continuously investigated for 4 years. It was found that 83% of KBD children had metaphyseal lesions and 66.9% of them had lesions in bone ends, and that the natural recovering rate of metaphyseal lesions from the 1st year to the 4th year was 22%, 43%, 57.8% and 73.6% respectively, and the natural recovely to the lesions of bone end was not found in all cases. It was also found that 25.2% of KBD children had an abnormal ratio of finger joint width and fingerwidth. Among them,2 changed from abnormal to normal and 17 from normal to abnormal. Only 2 children had an abnormal ratio of finger length and hand width. All the 84 normal children in the KBD-affected area had normal ratio of two ratios. No new case whose ratio turnd abnomal was found in 4 years. Our observations suggest that it is not reasonable to take the varying rate of metaphyseal lesions as the only evaluating criteria of cure and prevention of KBD because the natural recoveing rate of metaphyseal lesions is very high. It seems to be more reliable to combine the varying rate of metaphyseal leisions with the ratio of finger joint width and figer width as the evaluating criteria of cure and prevention of KBD.