ABSTRACT
Langerhans cell histiocytosis is a multi system disorder with a certain predilection for involving hypothalamic pituitary axis. We hereby report a 7 year old girl presenting with polyuria, polydipsia and growth retardation. The girl had a past history of pain in right hip joint and nodular region over chest. Water deprivation test confirmed the diagnosis of central diabetes inspidus. Other investigations revealed Growth hormone deficiency and central hypothyroidism. X-ray and MRI hip revealed absent right inferior pubic ramus with bone marrow biopsy confirming the diagnosis of histiocytosis. Patient was treated with nasal Arginine Vasopressin spray, subcutaneous growth hormone and oral thyroxine.
ABSTRACT
Se describe un caso de diabetes insípida post parotiditis, entidad sumamente rara en nuestro medio. Se destaca el diagnóstico y la terapéutica de esta entidad, así como la causa etiológico y forma de presentación.
A case of diabetes insipidus post-parotiditis is described entity totally rare in our midicu. Diagnostics and therapeutics are stressed a well as the ethiologic antecedent and way of presentation.
ABSTRACT
Sarcoidosis, a multisystemic disease of unknown cause characterized by the formation of noncaseat,ing granulomas, may involve any organ of the body. The most common sites of predilection are the lungs, lymph nodes, skin and eyes. Cutaneous sarcoidosis is seen in approximately 20-35% of patients with systcmic disease. Involvement of the central nervous system with sarcoidosis is relatively uncommon with an estimated incidence of only 3.5-5.0%. A 57-year-old male had been admitted to Department of Internal Medicine due to weight loss, polydipsia, polyuria, visual disturbance and bilateral hilar enlargement. He was diagnosed as sarcoidosis with diabetes inspidus by mediastinoscopic biopsy and a water deprivation test. On his first visit to dermatology he had several well-demarcated smooth-surfaced erythematous plaques on his forehead which had been there for 7 months. Histopathologically, many noncaseating epithelioid tubercles which are characteristic findings of sarcoidosis, were found in the dermis and subcutaneous tissue. We treated him with predniscilone 40 mg daily for 3 months and skin lesions markedly improved.