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AIM: To observe the clinical efficacy of multi -glycoside of tripterygium wilfordii (GTW) on diabetic nephropathy. METHODS: Fifty-one patients with diabetic kidney disease (DKD) with a history of GTW dosing admitted to the outpatient clinic of Yijishan Hospital affiliated to Wannan Medical College from June 2019 to October 2022 were selected as study subjects, and were followed up regularly to observe the changes in laboratory indexes before and after GTW dosing and adverse drug reactions after 6 months of treatment. The t-test, Mann-Whitney U-test or χ
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OBJECTIVE@#Scutellarin is a primary active composition come from Erigeron breviscapus. It is well known that scutellarin has anti-inflammatory and antioxidant physiological functions. In this study, we detected the effects of scutellarin on hepatocyte cell apoptosis in type 2 diabetes mellitus (T2DM) rats.@*METHODS@#Sprague Dawley (SD) (6-8 weeks, 160-180 g) rats were randomly divided into six groups: control, model, scutellarin low-dose, medium-dose, high-dose treatment, and rosiglitazone positive groups; with 10 SD rats in each group (n = 10). The changes of biochemical factors in serum were detected by automatic biochemical instrument, the pathological changes of liver tissue were detected by hematoxylin and eosin (HE) staining, the apoptosis of liver tissue and cells was detected by tissue staining and flow analyzer, and the expression of apoptosis-related factors were determined by qPCR, Western blot and immunohistochemistry in liver tissues or cells.@*RESULTS@#The results showed that scutellarin decreased the levels of fasting blood glucose, total cholesterol, triglyceride, and low-density lipoprotein and increased the levels of high-density lipoprotein. Meanwhile, scutellarin decreased the levels of alanine transaminase (ALT) and aspartate transaminase (AST) and improved liver function. In addition, scutellarin suppressed the secretion of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and reduced hepatocyte apoptosis. Furthermore, scutellarin inhibited the expression of cleaved Caspase-3, Bax, and cytochrome C (Cyt-C) and promoted the expression of Bcl-2.@*CONCLUSION@#Scutellarin can inhibit the apoptotic pathway, thereby relieving T2DM.
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Insulinoma-associated protein-2 (IA-2) is a transmembrane glycoprotein belonging to the tyrosine phosphatase-like protein family as well as an important autoantigen in the diagnosis of type 1 diabetes. IA-2 products have been marketed in Europe and the United States. At present, commercially available IA-2 antigens are either the recombinant IA-2ic domain or the IA-2 naturally extracted from bovine islets. However, the recombinant IA-2 antigen displays weak positive in clinic practice, which often results in occasional detection failures, thus cannot completely replace the naturally extracted IA-2 antigen. In this study, an HEK293 expression system was used to explore the production of recombinant IA-2. An IA-2 transmembrane fragment (IA-2 TMF) located at amino acid position 449-979, also known as the natural membrane protein form of IA-2, was produced in HEK293 through transfection, and both the expression conditions and dissolution conditions of the membrane protein were also optimized. The purified membrane protein yield was 0.78 mg/L cell culture. Subsequently, the antigen activity of IA-2 TMF was compared with RSR rhIA-2 through enzyme linked immunosorbent assay. The serum of 77 type 1 diabetes patients and 32 healthy volunteers were detected. Receiver operating characteristic curve (ROC) curve was used to characterize the sensitivity and specificity of the test results. The results showed that the sensitivity of IA-2 TMF was 71.4% (55/77), while the sensitivity of RSR rhIA-2 was 63.6% (49/77), and the specificity of both antigens were all 100%. There was no significant difference in specificity between the two antigens, but the sensitivity of IA-2 TMF was appreciably better than that of the imported gold standard RSR rhIA-2 antigen. In conclusion, the recombinant IA-2 TMF produced in HEK293 cells can be used as a raw material to develop in vitro diagnostic reagents for type 1 diabetes.
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Humans , Animals , Cattle , HEK293 Cells , Insulinoma , Diabetes Mellitus, Type 1/genetics , Recombinant Proteins , Membrane Proteins , Pancreatic NeoplasmsABSTRACT
OBJECTIVES@#The excretion of urinary vitamin D-binding protein (uVDBP) is related to the occurrence and development of early-stage renal damage in patients with Type 2 diabetes (T2DM). This study aims to explore the significance of detecting uVDBP in T2DM patients and its relationship with renal tubules, and to provide a new direction for the early diagnosis of T2DM renal damage.@*METHODS@#A total of 105 patients with T2DM, who met the inclusion criteria, were included as a patient group, and recruited 30 individuals as a normal control group. The general information and blood and urine biochemical indicators of all subjects were collected; the levels of uVDBP, and a marker of tubular injury [urine kidney injury molecule 1 (uKIM-1), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine retinol-binding protein (uRBP)] were detected by enzyme-linked immunosorbent assay. The results were corrected by urinary creatinine (Cr) to uVDBP/Cr, uKIM-1/Cr, uNGAL/Cr and uRBP/Cr. The Pearson's and Spearman's correlation tests were used to analyze the correlation between uVDBP/Cr and urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR) and markers of tubular injury, and multivariate linear regression and receiver operating characteristic curve were used to analyze the correlation between uVDBP/Cr and UACR or eGFR.@*RESULTS@#Compared with the normal control group, the uVDBP/Cr level in the patient group was increased (P<0.05), and which was positively correlated with UACR (r=0.774, P<0.01), and negatively correlated with eGFR (r=-0.397, P<0.01). There were differences in the levels of uKIM-1/Cr, uNGAL/Cr, and uRBP/Cr between the 2 groups (all P<0.01). The uVDBP/Cr was positively correlated with uKIM-1/Cr (r=0.752, P<0.01), uNGAL/Cr (r=0.644, P<0.01) and uRBP/Cr (r=0.812, P<0.01). The sensitivity was 90.0% and the specificity was 82.9% (UACR>30 mg/g) for evaluation of uVDBP/Cr on T2DM patients with early-stage renal damage, while the sensitivity was 75.0% and the specificity was 72.6% for evaluation of eGFR on T2DM patients with early-stage renal damage.@*CONCLUSIONS@#The uVDBP/Cr can be used as a biomarker in early-stage renal damage in T2DM patients.
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Humans , Diabetes Mellitus, Type 2/complications , Creatinine , Vitamin D-Binding Protein/urine , Lipocalin-2/urine , Kidney/metabolism , Glomerular Filtration Rate , BiomarkersABSTRACT
Objective:To analyze the correlation between serum bile acid and glycolipid metabolism in patients with type 2 diabetic mellitus (T2DM) and metabolically associated fatty liver disease (MAFLD).Methods:A total of 387 T2DM patients hospitalized in Jinan Central Hospital in Shandong Province from July 2020 to November 2021 were selected, including 140 T2DM patients (T2DM group) and 247 T2DM patients with MAFLD (T2DM with MAFLD group). Clinical data were collected of all patients for retrospective analysis and compare the differences in clinical datas in the T2DM group and the T2DM with MAFLD group. Analyze the influencing factors of T2DM with MAFLD. The serum total bile acid (S-TBA) of the T2DM with MAFLD group was divided into T1, T2 and T3 groups by the method of trisection. Triglyceride glucose index (TyG) and hemoglobin glycation index (HGI) were divided into low TyG group, high TyG group and low HGI group, high HGI group by their median values. The incidence of hyperlipidemia, degree of insulin resistance and glycosylated hemoglobin variation was compared among the three groups. To analyze the influencing factors of TyG and HGI. The measurement data conforming to the normal distribution were compared between two groups by independent sample t-test, the comparison between multiple groups by ANOVA, the comparison between two groups of measurement data not conforming to the normal distribution by Mann Whitney U test, and the comparison between multiple groups by Kruskal Wallis H test, χ 2 test was used for comparison of count data between groups. The influencing factors of T2DM with MAFLD and high HGI were analyzed by multivariate binary Logistic regression. The influencing factors of TyG were analyzed using multiple stepwise linear regression. Results:There was no significant difference between the S-TBA of T2DM group and T2DM with MAFLD group ( P>0.05). TyG ( OR=1.788, 95% CI: 1.223-2.614), superoxide dismutase (SOD) ( OR=1.019, 95% CI: 1.009-1.030) and VFA (visceral fat area) ( OR=1.021, 95% CI: 1.013-1.028) were risk factors for the occurrence of T2DM with MAFLD ( P values are 0.003, 0.001 and 0.001, respectively). The incidence of high TyG in T3 group (61.0% (50/82)) as higher than that in T1 group (40.0% (32/80)), the incidence of high HGI in T3 group (61.0% (50/82)) was higher than that in T2 group (41.2% (35/85)), the morbidity of hypercholesterolemia in T3 group (15.9% (13/82)) was higher than that in T2 group (4.7% (4/85)), the differences were statistically significant (χ 2 values were 7.13, 6.55, 5.67; the P values were 0.008, 0.011, 0.017). S-TBA, hepatic steatosis index (HSI) and VFA were independent influencing factors of TyG (the P values were 0.003, <0.001, <0.001). S-TBA ( OR=0.940, 95% CI:0.887-0.997) and fasting C peptide ( OR=0.454, 95% CI:0.219-0.940) were protective factors for the occurrence of high HGI (the P values were 0.039, 0.034). Conclusion:S-TBA was positively correlated with the degree of insulin resistance and incidence of hypercholesterolemia in patients with T2DM and MAFLD, negatively correlated with the degree of glycated hemoglobin variation.
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Angiosarcoma is a rare malignant tumor of soft tissue in adults. However, tumor ulcers caused by foot angiosarcoma are rarely reported in the literature. This paper outlines a case of foot angiosarcoma misdiagnosed as diabetic foot ulcer. It was treated as diabetic foot ulcer in other hospitals without notable improvement. In consideration of its special clinical characteristics and treatment process, pathological biopsy was performed after admission, and angiosarcoma was confirmed. The purpose of this article is to emphasize that foot angiosarcoma or other tumor ulcers in diabetes patients are easily misdiagnosed as diabetic foot ulcers. If there is no obvious improvement in treatment, pathological tissue biopsy should be performed as early as possible.
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BACKGROUND: Osteoporotic fracture combined with type 2 diabetic mellitus in female patients is often accompanied by dyslipidemia and hyperglycemia. In addition to insulin treatment, statins are often prescribed for combination therapy, but the combined effect of these two drugs on fracture healing has not been reported in such patients. OBJECTIVE; To investigate the effect of lovastatin combined with insulin on the fracture healing of bilateral ovariectomized rats suffering from type 2 diabetic mellitus. METHODS: The study was approved by the Ethical Committee of North China University of Science and Technology. Thirty-two female Sprague-Dawley rats were divided into control, diabetic ovariectomized, insulin and combined groups. A model of type 2 diabetes and osteoporosis fracture was established in all rats except for the control group. At 7 days after the type 2 diabetic model was successfully established by injection of streptozotocin, the rats in the insulin and combined groups received the subcutaneous injection of insulin (2-4 U in the morning, and 4-6 U in the evening) until the end of the experiment. The rats in the combined group were given 20 mg/kg lovastatin via gavage daily, and those in the other two groups were not treated. All rats were sacrificed at 3 weeks after fracture. Radiographic, clinical and histomorphometric detections of the callus were performed. The expression levels of bone morphogenetic protein 2, vascular endothelial growth factor and collagen type II were detected. All above results were used to analyze the fracture healing in each group. RESULTS AND CONCLUSION: (1)The radiographic score, micro-CT index, histologic score and the expression levels of vascular endothelial growth factor and collagen type II in the diabetic ovariectomized group were significantly poorer than those in the control group (P < 0.05). (2) All above indexes in the insulin group were significantly improved compared with the diabetic ovariectomized group (P < 0.05), which promoted the fracture healing of model rats. (3) After combined with lovastatin, although the expression levels of vascular endothelial growth factor and bone morphogenetic protein 2 in the callus were significantly increased (P < 0.05), there was no significant improvement in the radiographic appearance and microstructure of the callus.
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INTRODUCTION:-Metformin acts mainly at the liver by reducing glucose output and secondarily, by augmenting glucose uptake in the peripheral tissues, primarily muscle. These effects are facilitated by the activation of an upstream kinase, liver kinase B1 (LKB-1), which in turn controls the downstream kinase adenosine monophosphates protein kinase (AMPK). AMPK phosphorylates a transcriptional co-activator, transducer of regulated CREB protein 2, resulting in its inactivation which consequently down regulates transcriptional events that promote synthesis of gluconeogenic enzymes METHODOLOGY:- 200 total numbers of cases were included of diabetic mellitus who received 1500mg/day metformin. The duration of study was one year. RESULT:- In results observed that decrease in fasting blood glucose, total cholesterol, LDL- C and TGs. HDL-C levels were increased significantly after treatment. Conclusion:- Therefore, the findings of the present study concluded that metformin used in diabetic treatment improves lipid profile.
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Background: Diabetes mellitus (DM) is a leading non-communicable disease in India and contributes to 34% of mortality. Optimal management of DM involves a multipronged approach due to diverse factors including lifestyles, culture, myths, and socioeconomic condition. Self-care practices go a long way in the prevention of complications and improving quality of life. Objectives: The objectives of this study were to assess the self-care practices among type 2 adult diabetic populations in a tertiary health-care setting. Materials and Methods: A cross-sectional descriptive study was conducted on type II adult diabetic subjects in a tertiary care hospital. A pre-tested, structured pro forma was used to collect the baseline data and self-care practices including knowledge of the disease, dietary practices, exercise, habits, health-seeking practices, complications, and prevention of complications. Chi-square test and descriptive statistics were analyzed using SPSS (17.0). Results: A total of 101 patients were studied where 60% of them were males; 57% had diabetes history of >5 years, 44% overweight, and 16% obese. Knowledge about the disease such as risk factors (59%), complications (67%), and dietary practices (92%) was good. Self-care practices were poor with 17% following strict diet, 7% exercised regularly, and 52% of them got their blood glucose monitored periodically. 21% of them never took care of their feet, and up to 96% of them never carried diabetes identification card. The self-care practices were significantly better among literates as compared to illiterates. Conclusion: Although the awareness of the disease and complications is good, self-care practice is poor among the study population.
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Background: Diabetes mellitus (DM) is a clinical syndrome characterized by hyperglycaemia due to absolute or relative insulin deficiency. Cardiovascular autonomic neuropathy (CAN) invokes potentially life-threatening outcomes especially in poorly controlled diabetic patients. This study was to evaluate the prevalence of CAN in diabetic patients and its relationship with QTc interval.Methods: This observational study of two year duration was included total 123 patients of more than 30 (thirty) years and up to 60 (sixty) years of age who were presented with diabetic mellitus (DM) those were evaluated for CAN using four distinct clinical tests-Resting heart rate (RHR), test for orthostatic hypotension (OH), hand gripping test (HGT) and QTc interval on ECG. Data were analyzed with statistical package for social sciences (SPSS), version 23.Results: The mean age of all 103 studied patients was 48.94±8.69 years; Mostly patients belong to 50-60 years of age and the majority was males (69.0%). Out of 103 72.8% patients were reported with CAN (51 males and 24 females) and without CAN were 27.2.0% (20 males and 8 females), 36% of patients of Definite Parasympathetic neuropathy, 25% Normal and 20% of Sympathetic neuropathic patients. HbA1c level increases the danger of CAN also. QTc interval is a reliable indicator for the presence of CAN.Conclusions: Duration of diabetes is directly proportional to the prevalence of CAN. Various cardiac autonomic function tests detect CAN.
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Background: Diabetes levies a heavy toll on the vascular system, with both macrovascular and microvascular complications. PAD is one of the major microvascular complications of Type 2 DM [2]. PAD is highly prevalent in diabetes. It has a predilection for lower limbs. It has been assumed that the metabolic abnormality in the prediabetic phase predisposes to more distal and aggressive atherosclerosis. Methods: The duration of study was over a period of 6 month. Total 75 cases were included in this study with diabetic mellitus. This study was conducted in the Department of surgery in Krishna Mohan Medical College & Hospital, Mathura, U.P, India. Result: In our study 75 cases with diabetic mellitus were included. Out of 75 cases 64% male & 36% were female. Predominant age was >75 year followed by other age groups. In this present study, 15 cases of hypertensive & 2 cases of PVD out of hypertensive were found. Conclusion: This study suggested that incidence of PVD is about 10% in the present study. This has to be viewed seriously considering the huge diabetic population and due importance to be given for screening and prevention of PVD.
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Objetivo: Determinar la relación entre conocimientos y aptitudes en pacientes diabéticos sobre las complicaciones crónicas de la diabetes mellitus 2 en el servicio de endocrinología del Hospital Nacional PNP Luis N. Suárez el 2016. Métodos: Estudio cuantitativo, descriptivo, transversal y correlacional. Se encuestaron a 110 pacientes diabéticos con un cuestionario para valorar los conocimientos (10 ítems con respuesta de selección múltiple) y otro para las aptitudes (tipo Lickert modificado). Los conocimientos se clasificaron como nivel alto, medio y bajo y las aptitudes como favorables, desfavorables e indiferentes según la Escala de Estanones. Se determinó la normalidad de las puntuaciones con la Prueba de Kolmogorov-Smirnov y las asociaciones con chi cuadrado, p<0.05 y prueba de correlación de Pearson. Resultados: La edad media fue 49.85±6.97 años, 74.5% sexo femenino, 75.5% con tiempo de enfermedad entre 1-5 años, 67.3% con buena adherencia al tratamiento farmacológico. El nivel de conocimientos fue: alto 28.2%, medio 49.1% y bajo 22.7%; y las aptitudes fueron: favorables 23.6%, desfavorables 58.2% e indiferentes 18.2%. No existe relación entre conocimientos y aptitudes (p=0.247). Sólo se encontró asociación estadística entre conocimiento y tratamiento farmacológico (p<0.05). Conclusión: Los pacientes diabéticos tienen un nivel de conocimiento medio sobre sus complicaciones crónicas y sus aptitudes fueron predominantemente desfavorables. Es necesario realizar estrategias educativas para mejorar los conocimiento y las aptitudes de los diabéticos.
Objective: To determine the relationship between knowledge and aptitude in diabetic patients regarding the chronic complications of diabetic mellitus 2 in the endocrinology service of National Hospital PNP Luis N. Saenz. Methods: Quantitative, descriptive, transverse and correlational study. 110 diabetic patients were surveyed with a questionnaire to assess the knowledge (10 items with a multiple choice response) and another one for the skills (modified Lickert type). The knowledge was classified as high, medium and low level and the skills as favorable, unfavorable and indifferent according to the Estanones Scale. The normality of the scores with the Kolmogorov-Smirnov test and associations with chi-square, p <0.05 and Pearson's correlation test were determined. Results: The mean age was 49.85 ± 6.97 years, 74.5% female, 75.5% with disease time between 1-5 years, 67.3% with good adherence to pharmacological treatment. The level of knowledge was: high 28.2%, medium 49.1% and low 22.7%; And the skills were: favorable 23.6%, unfavorable 58.2% and indifferent 18.2%. There is no relation between knowledge and skills (p = 0.247). Only statistical association was found between knowledge and pharmacological treatment (p <0.05). Conclusion: Diabetic patients have an average level of knowledge about their chronic complications and their abilities were predominantly unfavorable. It is necessary to carry out educational strategies to improve the knowledge and skills of diabetics.
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Background: Diabetic retinopathy (DR) causes significantvisual loss on a global scale. Hence, we planned the presentstudy to assess the prevalence of diabetic retinopathy in Type2 diabetic patients.Materials & Methods: The present study included assessmentof prevalence of diabetic retinopathy in Type 2 diabeticpatients. A total of 100 diabetic patients were included in thepresent study. Complete examination was carried out toassess the prevalence of diabetic retinopathy among diabeticpatients. All the results were compiled and analyzed by SPSSsoftware.Results: Diabetic retinopathy was found to be present in 25percent of the patients. Significantly higher prevalence ofdiabetic retinopathy was seen in subjects of more than 50years of age.Conclusion: Diabetic retinopathy is significantly associated indiabetic patients, with significantly higher prevalence in elderlypatients.
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Objective To explore the association between test results of human biological stimulation feedback instrument (EZSCAN) and blood glucose levels. Methods Data were collected from the general population who received health checkups that included examination of the autonomic nervous system function using the EZSCAN human biological stimulation feedback instrument from January to December 2017 in Shanghai Eastern Hospital. In accordance with the inclusion and exclusion criteria, 2136 cases (1122 men and 1024 women), with an average age of (50.7 ± 12.9) years, were enrolled in the final analysis. Participants were divided according to the diabetic risk scores obtained by EZSCAN into the control group (n=784 cases), low-risk group (n=801 cases), and high-risk group (n=551 cases). Fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels were statistically compared between groups. Participants were divided into four groups according to FPG quartiles [Group F1 (FPG≤4.76 mmol/L, n=546 cases), Group F2 (4.76 mmol/L<FPG≤5.14 mmol/L, n=536 cases), Group F3 (5.14 mmol/L<FPG≤5.58 mmol/L, n=526 cases), and Group F4 (FPG>5.58 mmol/L, n=528 cases)] and HbA1c quartiles [Group H1 (HbA1c≤5.3％, n=630 cases), Group H2 (5.3％<HbA1c≤5.6％, n=620 cases), Group H3 (5.6<HbA1c≤5.9％, n=429 cases), and Group H4 (HbA1c>5.9％, n=457 cases)]. EZSCAN test results were compared between the quartile groups. Correlations between EZSCAN results and FPG levels and HbA1C levels were analyzed. Results There were statistical differences in both FPG levels and HbA1c levels between participants in the control group, low-risk group, and high-risk group [FPG: (5.10 ± 1.06) mmol/L, (5.47 ± 1.36) mmol/L, and (5.59 ± 1.32) mmol/L, respectively, F=29.47, P<0.05; HbA1C:(5.95 ± 0.99)％, (5.79 ± 0.89)％, and (5.50 ± 0.70)％, respectively, F=47.42, P<0.05]. With increases in both FPG and HbA1C quartile levels, the EZSCAN scores showed a statistically increasing tendency [Groups F1-F4:(30.1 ± 14.6), (32.9 ± 15.2), (33.8 ± 15.1), and (39.1 ± 15.6), F=32.98, P<0.05;Groups H1-H4: (29.1 ± 14.4), (31.9 ± 14.2), (37.2 ± 15.3), and (40.3 ± 15.8), F=61.36, P<0.05]. Both FPG and HbA1c levels were positively correlated with diabetic risk scores (r=0.22 and 0.32, P<0.05). Conclusion Test results using the EZSCAN human biological stimulation feedback instrument showed significantly positive correlations with blood glucose levels.
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Objective To assess the impact of glycemic variability on left ventricular function in patients with acute ST-segment elevation myocardial infarction (STEMI) and type 2 diabetes.Methods Three hundred and three patients with type 2 diabetes and first STEMI between May 2014 and December 2016 in Beijing Anzhen Hospital,Capital Medical University were seclected continuously.All participants' continuous glucose monitoring system (CGMS) parameters,echocardiogram and biochemical characteristics were measured at baseline.According to the level of mean amplitude of glycemic excursion (MAGE) which is the gold indicator to present glycemic variability patients were classified into low MAGE group (n=182) and high MAGE group (n =117).Impact of glycemic variability on left ventricular function in patients with acute ST-segment elevation myocardial infarction and type 2 diabetes were analysed.Results (1) Cardiac function evaluation:The level of left ventricular ejection fraction (LVEF) were significantly lower in high MAGE group than in low MAGE group ((43.8± 7.2) vs.(52.3± 8.5) ％,t =4.912,P＜ 0.001).There were significant differences between the two groups in Killip classification (x2 =49.931,P＜ 0.001).(2) Pearson correlation analysis shows that LVEF negatively correlated with the levels of MAGE(r=-0.367,P＜0.001),postprandial glucose excursion (PPGE) (r=-0.274,P=0.003),Hemoglobin A1c(HbA1c) (r=-0.238,P =0.010),serum highsensitive C-reactive protein (hs-CRP) via logarithmic transformation (r =-0.245,P =0.008) and fasting plasma glucose (FPG) (r =-0.229,P =0.021).Killip classification positively correlated with the levels of MAGE (r =0.301,P ＜ 0.001),PPGE (r =0.228,P =0.022),hs-CRP via logarithmic transformation (r =0.234,P =0.019),H bA 1 c (r =0.195,P =0.041) and FPG (r =0.193,P =0.045).(3) Multiple stepwise regression analysis and multivariate Logistic regression analysis indicated that the level of MAGE was independent risk factor of LVEF (t =-2.279,P =0.005,95％ CI(-3.160 -0.219)) and the level of MAGE was an independent risk factor of Killip classification (Waldx2 =5.673,OR=1.665,95％CI(1.095-2.534),P=0.017).Conclusion Glycemic variability is associated with the presence and severity of left ventricular function in patients with STEMI and type 2 diabetes.
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From September to October 2018, a questionnaire survey was conducted on the status of diabetes management, basic equipment allocation, complication screening and follow-up, basic drug supply and health education among 136 grassroots institutions in Nanjing. Doctors in the 136 grassroots institutions who had received diabetes specialist training accounted for 18.2% (358/1 968) of total general practitioners. The management rate of diabetes patients was 98.67% (196 352/199 000) , and the standard management rate was 88.63%(174 024/196 352).The screening and follow-up rates of diabetic complications were 89.0%(121/136) and 61.2%(74/121) for glycosylated hemoglobin; 64.7%(88/136), 58.0%(51/88) for urine microalbumin;51.5% (70/136), 62.9%(44/70) for diabetic foot; 44.9%(61/136), 42.6%(26/61) carotid ultrasonography; 32.4%(44/136) and 59.1%(26/44) for fundus examination; 17.6%(24/136) and 33.3%(8/24) for ankle brachial index. The rates of screening for glycosylated hemoglobin, urinary microalbumin, diabetic foot, carotid B ultrasound, fundus and ankle brachial index in urban areas were significantly higher than those in the suburbs (both P<0.05). The diabetes health education was regularly conducted in 92.0%(126/136) of grassroots institutions. At present, the grassroots institutions in Nanjing have established health archives for most diabetic patients and conducted health education regularly, but the professional training and the screening of diabetic complications need to be strengthened.
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Objective@#To compare the anterior capsule opacification and contraction of lens following femtosecond laser-assisted cataract surgery versus conventional phacoemulsification for cataract patients with diabetes.@*Methods@#A non-randomized control study was carried out.Eighty-five eyes of 85 cataract patients with diabetes were included from March 2015 to August 2016 in Xiamen Eye Center.The patients were divided into 2 groups based on the different surgeries.Forty-three eyes of 43 patients in the femtosecond laser group received femtosecond laser-assisted phacoemulsification and completed the 5.3 mm capsulorhexis using the Alcon LenSx femtosecond laser platform.Forty-two eyes of 42 patients in the conventional surgery group underwent conventional phacoemulsification group and performed 5.3 mm continuous circular capsulorhexis under the guidance of Alcon VERION.Anterior capsule opacification (ACO) was graded according to Werner's method.The area of anterior capsular opening was calculated by using Image Pro Plus 6 software.The number of eyes in different grades of ACO and anterior capsule opening area between two groups were compared at 1 month, 3 months and 6 months after operation.@*Results@#Initial anterior capsular opening area was not significantly different between the femtosecond laser group and the conventional phacoemulsification group (t=0.003, P=0.958). The anterior capsule opening area in the two groups among different time-points after operations was significantly different (Fgroup=73.602, P<0.001; Ftime=378.895, P<0.001), and anterior capsule opening areas were smaller in the conventional phacoemulsification group than those in the femtosecond laser group at various time points after operation (all at P<0.001). At 1 month after suigery, grade Ⅰ of the ACO was found in 29 eyes (67.4%) in the femtosecond laser group and 26 eyes (61.9%) in the conventional phacoemulsification group, and there was no significant difference between two groups (P=0.133). At 3 months after surgery, the incidence rate of grade Ⅱ of ACO was 11.6% (5/43) in the femtosecond laser group, which was lower than than that in the conventional phacoemulsification group(66.7%, 28/42), showing a significant difference between them (P<0.001). At the 6th month after operation, the incidence rate of grade Ⅲ of ACO in the femtosecond laser group was 14.0%(6/43), which was lower than that in the conventional phacoemulsification group(73.8%, 31/42), with a significant difference between them (P<0.001).@*Conclusions@#Femtosecond laser-assisted cataract surgery for cataract is a good choose patients with diabetes mellitus because of reducing the occurrence of ACO and the contraction of anterior capsule.
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From September to October 2018,a questionnaire survey was conducted on the status of diabetes management,basic equipment allocation,complication screening and follow-up,basic drug supply and health education among 136 grassroots institutions in Nanjing.Doctors in the 136 grassroots institutions who had received diabetes specialist training accounted for 18.2％ (358/1 968) of total general practitioners.The management rate of diabetes patients was 98.67％(196 352/199 000),and the standard management rate was 88.63％(174 024/196 352).The screening and follow-up rates of diabetic complications were 89.0％(121/136) and 61.2％(74/121) for glycosylated hemoglobin;64.7％(88/136),58.0％(51/88) for urine microalbumin;51.5％ (70/136),62.9％(44/70) for diabetic foot;44.9％(61/136),42.6％(26/61) carotid ultrasonography;32.4％(44/136) and 59.1％(26/44) for fundus examination;17.6％(241136) and 33.3％(8/24) for ankle brachial index.The rates of screening for glycosylated hemoglobin,urinary microalbumin,diabetic foot,carotid B ultrasound,fundus and ankle brachial index in urban areas were significantly higher than those in the suburbs (both P＜0.05).The diabetes health education was regularly conducted in 92.0％(126/136) of grassroots institutions.At present,the grassroots institutions in Nanjing have established health archives for most diabetic patients and conducted health education regularly,but the professional training and the screening of diabetic complications need to be strengthened.
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Objective To compare the anterior capsule opacification and contraction of lens following femtosecond laser-assisted cataract surgery versus conventional phacoemulsification for cataract patients with diabetes. Methods A non-randomized control study was carried out. Eighty-five eyes of 85 cataract patients with diabetes were included from March 2015 to August 2016 in Xiamen Eye Center. The patients were divided into 2 groups based on the different surgeries. Forty-three eyes of 43 patients in the femtosecond laser group received femtosecond laser-assisted phacoemulsification and completed the 5. 3 mm capsulorhexis using the Alcon LenSx femtosecond laser platform. Forty-two eyes of 42 patients in the conventional surgery group underwent conventional phacoemulsification group and performed 5. 3 mm continuous circular capsulorhexis under the guidance of Alcon VERION. Anterior capsule opacification (ACO) was graded according to Werner's method. The area of anterior capsular opening was calculated by using Image Pro Plus 6 software. The number of eyes in different grades of ACO and anterior capsule opening area between two groups were compared at 1 month,3 months and 6 months after operation. Results Initial anterior capsular opening area was not significantly different between the femtosecond laser group and the conventional phacoemulsification group (t=0. 003,P=0. 958). The anterior capsule opening area in the two groups among different time-points after operations was significantly different (Fgroup=73. 602, P<0. 001;Ftime=378. 895,P<0. 001),and anterior capsule opening areas were smaller in the conventional phacoemulsification group than those in the femtosecond laser group at various time points after operation ( all at P<0. 001 ) . At 1 month after suigery, grade Ⅰ of the ACO was found in 29 eyes ( 67. 4％) in the femtosecond laser group and 26 eyes ( 61. 9％) in the conventional phacoemulsification group,and there was no significant difference between two groups (P=0. 133). At 3 months after surgery,the incidence rate of gradeⅡof ACO was 11. 6％ (5/43) in the femtosecond laser group,which was lower than than that in the conventional phacoemulsification group ( 66. 7％, 28/42 ) , showing a significant difference between them (P<0. 001). At the 6th month after operation,the incidence rate of grade Ⅲ of ACO in the femtosecond laser group was 14. 0％(6/43),which was lower than that in the conventional phacoemulsification group (73. 8％,31/42),with a significant difference between them (P<0. 001). Conclusions Femtosecond laser-assisted cataract surgery for cataract is a good choose patients with diabetes mellitus because of reducing the occurrence of ACO and the contraction of anterior capsule.
ABSTRACT
Background: By 2025, India due to its immense population size and high diabetes prevalence will contribute about 57 million diabetics. Hence the aim of the present study was clinical presentations of diabetes in children attending the paediatric ward in the medical institute.Methods: Total of 50 cases were included in the study. All the children who were less than age of 18years and also diagnosed with diabetes that is fasting blood sugar >126mg/dl or random blood sugar level > 200 mg/dl were included in the study. A detailed clinical examination of the child was carried out with detailed anthropometric measurements. Metabolic profile was done by investigating for the following. Fasting blood sugar, post prandial blood sugar, glycoslated haemoglobin.Results: The various ranges of fasting blood sugar were as follows: 25% were in the range of 130-200mg/dl, 35% in 200-300 mg/dl, 25% in 300-400mg/dl and 15% had more than 400 mg/dl fasting blood sugar levels. The various ranges of post prandial blood sugar were as follows: 16% were in the range of 200 - 300mg/dl, 40% in 300-400mg/dl, 44% had more than 400 mg/dl post prandial blood sugar levels. In the present study lipid profile of all the children was analysed by their serum cholesterol and triglycerides.Conclusions: A total of 50 diabetic children of age less than 18 years attending medical Hospital were studied using a predesigned and pretested proforma. Information was collected on socio-demographic, dietary intake, treatment and compliance history. Detailed clinical examination done and anthropometric measurements were taken. Metabolic profile was done by investigating for blood sugar levels, glycoslated haemoglobin and lipid profile. In the present study 46% had onset of diabetes mellitus at 15 to 18 years age group with male to female ratio of 1.26:1.