Reasonably conduct the multiple Logistic regression analysis combined with the ROC curve analysis / 四川精神卫生

The purpose of this paper was to introduce how to reasonably carry out the method of the multiple Logistic regression analysis by combining the ROC curve analysis. Firstly， it introduced two groups of the basic concepts related to the ROC curve analysis， that was， the statistical description of common diagnostic indicators and the ROC curve analysis method of the diagnostic data. Secondly， it introduced the core contents of the ROC curve analysis， that was， the calculation of the area under the ROC curve and the comparison of the area under multiple ROC curves. Thirdly， through an example of a diagnostic test， the whole process of how to use SAS software for the analysis was introduced， the contents were as follows： ① the analysis using only multiple Logistic regression analysis； ② the multiple Logistic regression analysis combined with the ROC curve analysis. The conclusion was that， for the diagnostic test data， combining the multiple Logistic regression analysis with the ROC curve analysis could obtain richer and more reasonable statistical analysis results.

Development and Validation of a Simple Index Based on Non-Enhanced CT and Clinical Factors for Prediction of Non-Alcoholic Fatty Liver Disease

OBJECTIVE: A widely applicable, non-invasive screening method for non-alcoholic fatty liver disease (NAFLD) is needed. We aimed to develop and validate an index combining computed tomography (CT) and routine clinical data for screening for NAFLD in a large cohort of adults with pathologically proven NAFLD.MATERIALS AND METHODS: This retrospective study included 2218 living liver donors who had undergone liver biopsy and CT within a span of 3 days. Donors were randomized 2:1 into development and test cohorts. CT(L-S) was measured by subtracting splenic attenuation from hepatic attenuation on non-enhanced CT. Multivariable logistic regression analysis of the development cohort was utilized to develop a clinical-CT index predicting pathologically proven NAFLD. The diagnostic performance was evaluated by analyzing the areas under the receiver operating characteristic curve (AUC). The cutoffs for the clinical-CT index were determined for 90% sensitivity and 90% specificity in the development cohort, and their diagnostic performance was evaluated in the test cohort.RESULTS: The clinical-CT index included CT(L-S), body mass index, and aspartate transaminase and triglyceride concentrations. In the test cohort, the clinical-CT index (AUC, 0.81) outperformed CT(L-S) (0.74; p < 0.001) and clinical indices (0.73–0.75; p < 0.001) in diagnosing NAFLD. A cutoff of ≥ 46 had a sensitivity of 89% and a specificity of 41%, whereas a cutoff of ≥ 56.5 had a sensitivity of 57% and a specificity of 89%.CONCLUSION: The clinical-CT index is more accurate than CT(L-S) and clinical indices alone for the diagnosis of NAFLD and may be clinically useful in screening for NAFLD.

Rehabilitación de maxilares clases I y II de Kennedy mediante prótesis removibles / Rehabilitation of maxillary Kennedy class I & II treated with removable dentures

RESUMEN: La irrupción de los implantes óseo integrados y su posterior validación, a comienzos de los años '80, aportó sin duda un utilísimo recurso en la rehabilitación oral. Lamentablemente, en gran medida debido a los costes económicos involucrados, a pesar de alentadores augurios, no han devenido en una alternativa terapéutica concreta para la gran mayoría de los pacientes desdentados. El edentulismo parcial de maxilas, clases Kennedy I y II, con remanencia de todos o parte de los dientes del sextante 2, en su mayoría casos de sustancial complejidad, léase clases III del Índice Diagnóstico Prostodóntico, genera un desafío protésico a solventar en relación a la retención y satisfacción estética de los pacientes. Presentamos en este reporte dos de estos casos, rehabilitados mediante prótesis metálicas "convencionales", en los cuales creemos logramos conjugar acertadamente ambas variables, combinando complejos retentivos RMC y facetas retentivas friccionales.

ABSTRACT The emergence of osseointegrated implants and their further validation, at the beginning of the 80's, contributed undoubtedly to oral rehabilitation as a very useful resource. Unfortunately, mainly because of the economic costs involved and despite an encouraging initial augury, they have not become in a specific therapeutic alternative for the vast majority of edentulous patients. Partial edentulism of maxillae, Kennedy's class I, & II, with all or a few teeth remaining at the sextant 2, mostly class III PDI, substantially compromised denture-supporting anatomy, generate a prosthetic challenge to overcome regarding retention and aesthetic satisfaction of these patients. In this report, we display two of them, which we believe have been successfully managed in order to fulfill both variables, by means of "conventional" removable metallic prostheses combining MGR's clasps and frictional retentive facets.