ABSTRACT
Objective To observe the expression of HBV-DNA and whether there were copy of HBV in the umbilical cord tissues of the died fetus delivered from puerpera with hepatitis virus B. Methods 40 cases such died fetus were collected by routine autopsy to obtain umbilical cord tissues.And using in situ molecular hybridization technique detected HBV-DNA. Results For the umbilical cord tissues, there were 40%(16/40) cases detected out HBV-DNA.HBV-DNA mainly localization in the surface of the umbilical cord vessel and in the cytoplasma of the cord vessel's endothelial cells. They were not in the cord vessel's endothelial cells nuclei. Conclusions There were HBV replication in the umbilical cord tissues of the died fetus. But the expression of HBV-DNA in the umbilical cord tissues of the died fetus is not related with the HBV replication status in the pregnant woman veins.
ABSTRACT
0 05). HBV-DNA were mainly localized on the surface of the umbilical cord vessel and in the plasma of the cord vessel's endothelial cells. HBV-DNA in the cord vessel's endothelial cells nuclei was not seen.Conclusion There were HBV replication in the umbilical cord tissues of the died fetus. But expression of HBV-DNA in the umbilical cord tissues of the died fetus was not related with the HBV replication status in the pregnant woman veins.