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Objective To analyze the cancer mortality and epidemiological characteristics of digestive system cancer in Xianyou County, Fujian Province, and to provide a scientific evidence for formulating preventive measures for digestive system cancer. Methods Excel and SPSS software were used to collect the monitoring data of digestive system cancer death in Xianyou County from 2014 to 2018, and then analyzed the mortality, the standardized rate (according to the Chinese 2000 population census) and the cause of death. Results From 2014 to 2018, the deaths of malignant tumors in Xianyou County accounted for 35.00% of all deaths. Among them, the four common digestive system malignant tumors (gastric cancer, esophageal cancer, liver cancer and colorectal cancer) accounted for 62.44% of malignant tumors. Gastric cancer ranked first and accounted for 27.36%. Average annual rate of crude mortality and standardized mortality of malignant tumor in the digestive system were 108.93/105 and 89.34/105, respectively, and the ratio of male to female was 2.27 to 1. Significant differences were found between town and village, as the terrain gets lower, the death rate goes down gradually. Compared with the data of 2011-2012, the standardized death rate of gastric cancer, esophageal cancer and liver cancer were reduced by 29.71%, 23.92% and 12.06%, respectively, while the rate of colorectal cancer was increased by 28.80% and the average annual growth rate was 7.83%. Conclusion Although the death rates of gastric cancer, esophageal cancer and liver cancer have decreased significantly, the malignant tumor of the digestive system is still the main disease that causes the death of residents in Xianyou County, Putian City. Therefore, it is necessary to strengthen the education of health in order to achieve the early discovery, diagnosis and treatment.
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Long non-coding RNAs(lncRNAs)is a functional RNA molecule with a sequence length greater than 200 nucleo-tides that is not translated into a protein. LncRNA is of great value in the clinical application of malignant tumors and is closely related to the diagnosis,prevention,treatment and prognosis of tumors. CCAT1(human colon cancer associated transcript-1)can play a carci-nogenic role by promoting cell proliferation,invasion and migration. CCAT1 can be used as a biomarker for tumor prognosis. In this re-view,the research progress on the relationship between CCAT1 and digestive system malignant tumors is reviewed in recent years,the current status and prospects of malignant tumor treatment by CCAT1 are discussed.
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Objective To evaluate the reliability, validity and applicability of the family caregiver burden scale (CBS-CP) for cancer patients. Methods The family caregivers of patients with digestive system cancer were selected as the research subjects. The reliability was evaluated by applying the Cronbach alpha coefficient and the half confidence level. The validity was evaluated by using criterion related validity. Applicability evaluation included: to analyze the burden level of family caregivers of patients with digestive system cancer;and to explore the influencing factors of caregiver burden. Results Except for factor 5, the Cronbach's alpha coefficient and the half coefficient level of the total CBS-CP and the other 4 factors were all higher than 0.75. The total scores and factors of CBS-CP were positively correlated with depression and anxiety (all P<0.01,r=0.296-0.505), and negatively correlated with the quality of life [except for the relationship between factor 5 and physical component summary score (P<0.05), the remaining Ps<0.01, r=0.126-0.370]. The total caregiver burden score ranged from 0 to 109, with an average of 46.03 ± 22.96;multiple regression analysis showed that the possible predictor variables of the total caregiver burden included:anxiety/depression, the disturbed life of family caregivers, quality of life, family economic pressure, spouse caregivers and caregivers'health status. Conclusions The findings showed that both the reliability and validity of the CBS-CP were good. The burden of family caregivers in patients with digestive system cancer is generally at a mild level, and the factors affecting the caregiver burden included physical, psychological, social and economic aspects. It was proposed that the influencing factors of caregiver burden should be explored through the dyadic level of caregivers and patients in future research, so as to provide scientific basis for the development of relevant interventions.
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Mucin is widely expressed in various tissues and organs.The abnormal expression of mucin can be found in many digestive system malignancies,which may be related to the Wnt signaling pathway.Mucins 1 and 4 can promote the occurrence,development and malignancy of various digestive system cancers,and even promote tumor invasion and metastasis.The expression levels of Mucin 2 in different types of tumors are different,and the high or low expression has different role in tumor promotion and inhibition.Mucin 15 is abnormally lowly expressed in digestive system cancers,which involves in tumorigenesis and development as well as invasion and metastasis.Mucins 3,5 and 6 are also more closely related to digestive system cancers.In this paper,the research progress on the relationship between mucins and digestive system cancers was reviewed.
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HOTTIP RNA is a type of long non-coding RNA, which is transcribed from the HOXA gene at its distal tip and coordinates the activation of 5'HOXA genes. Particularly, it regulates the expression of the neighboring HOXA 13 gene. Recently, emerging lines of evi-dence have suggested that increased expression of HOTTIP is observed in digestive system carcinomas, including esophageal cancer, gastric cancer, hepatocellular carcinomas, pancreatic cancer, and colorectal cancer, and is closely associated with the initiation and pro-gression of cancer, and affects the survival and prognosis of cancer patients. Therefore, it is expected to be a diagnosis index marker, prognosis indicator, and a new therapeutic target for the relevant tumors. Here, we focus on the discovery of lncRNA HOTTIP, its mech-anism, and the latest developments in the research on HOTTIP in digestive system carcinomas.
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S100A6 is the member of the S100 family of EF-hand calcium-binding proteins,which participates in inflammatory reaction and regulates in cell growth,differentiation,growth inhibition and apoptosis.Recently it has been reported that S100A6 plays a key role in neoplastic transformation,proliferation and invasion of tumor,it may become a potential target in the diagnosis and treatment of tumor.Here is to review the recent advances in the research on this molecule,including its structure,function mechanism,and its relationship with the gastrointestinal cancer and so on.
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Background and purpose:Henan is a big agricultural province and the high mortality rate of digestive system cancer threatened the life and the health of the people.In order to make some good strategies,we investigated the mortality rate and characteristic distribution of digestive system cancer in Henan province. Methods :The mortality and age-standardized mortality rate from 1987 to 2006 in Henan province were analyzed by using the data from registration system of all causes of death from 1/10 population in Henan province. Results :The crude mortality rate of digestive system cancer from 1987 to 2006 in Henan province was 81.95/10 5,and the age-standardized mortality in Chinese standard population was 71.31/10 5,which accounted for 71.29% of all cancers.The mortality rates,age-standardized mortality in male was 101.17/10 5 and 94.81/10 5 respectively,compared to 61.58/10 5 and 49.28/10 5 respectively in female.The foremost four in rank of the digestive system cancer were gastric cancer,esophageal cancer,liver cancer and intestinal cancer.The mortality of digestive system cancer has descended in the recent twenty years.Comparing in 1987 and in 2006,the age-standardized mortality rates of gastric cancer and esophageal cancer had decreased significantly from 30.38/10 5 to 21.27/10 5 and from 34.12/10 5 to 15.70/10 5 respectively.The death rate of intestinal cancer remained constant.But age-standardized mortality rate of liver cancer had increased significantly from 12.45/10 5 in 1987 to 18.26/10 5 in 2006. Conclusions :The distribution of death rate of digestive system cancer had changed greatly,so the prevention measures have to be changed accordingly.
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Objective:To study the effect of anxiety and depression in 46 digestive system cancer patients' prognosis.Methods:The differences of SDS mark?SAS mark and ≥ 50 mark percentage were compared between patients and common mould in nationwide adopting SDS and SAS,moreover the prognosis was compared between varying degrees of anxiety and depression in patients.Results:The SDS mark?SAS mark and ≥ 50 mark percentage in patients were obviously higher than that in common mould in nationwide;the patients with anxiety and depression had bad prognosis.Conclusion:The results suggest that anxiety and deprssion is common feeling in digestive system cancer patients and seriously influence the patients' prognosis,psychotherapy must be conducted and it may contribute to improve the patient's prognosis.