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@#Abstract: Parasites such as schistosome, liver fluke, and echinococcus mainly parasitize or cause diseases in the liver, and liver fibrosis is the main pathological feature and primary cause of morbidity and mortality of hosts after infection. The liver fibrosis caused by these parasites still has a heavy disease burden in the world, and due to its unique disease characteristics, the animal model of liver fibrosis caused by parasites has a unique position in the study of liver fibrosis. The essential distinguishing feature of parasitic infection-induced hepatic fibrosis from other types of hepatic fibrosis is the variety of parasitic-secreted molecules initiating fibrosis, including proteins, nucleic acids, lipids, metabolic small molecules and other types. These molecules induce the formation of type 2 immunity or inflammatory microenvironment in the host liver. Although in-depth research has been conducted on the initiation, maintenance, and regression of type 2 immunity in the liver after parasitic infection, many core mechanisms remain unclear. Chronic inflammation ultimately activates stellate cells and other types of cells to differentiate into myofibroblasts (MF), thus promoting the formation of liver fibrosis. After clearing parasites, MF may undergo reverse differentiation, apoptosis or senescence, and liver fibers may undergo reversal. Deep research on the activation and regression of MF is the foundation for effective prevention and treatment of liver fibrosis. This article reviews the disease burden and pathological characteristics of liver fibrosis caused by parasite infection.
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[Objective]This paper will pitch-in TCM psychosomatic theory(from Huangdi Neijing),exploring the disorders of depression with the metabolic syndrome and pathogenesis of traditional Chinese medicine,so as to provide effective ideas for the treatment of depression with metabolic syndrome.[Methods]:Through expansion on traditional chinese medicine's basic understanding of depression with metabolic syndrome,utilizing basic TCM viscera-state theory, from the causes of this disease,key factors,pathogenesis transformation three aspects to discuss the pathogenesis of the disease. [Results]By discussing the heart,liver,spleen function of zang-fu organs and their mutual relations in the role and impact of the disease development process, this paper thinks of the nature of disease as asthenia in origin and asthenia in superficiality,which locates in spleen,has association with heart and liver, phlegm, qi and blood stasis is the disease of pathological product of pathological factors to promote the development of the disease.Kidney would be involved in it with long course of disease.The therapy could focus on tonifying spleen,nourishing heart and soothing liver,with methods of promoting the circulation of qi,removing blood stasis and reducing phlegm,meanwhile looking out to protect kidney.[Conclusion]Disorder of depression and pathogenesis of TCM of metabolic syndrome,to guide the clinical treatment of the disease and the theory of traditional Chinese medicine development has practical significance.
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Skin prick tests (SPTs) are widely used to demonstrate an IgE-mediated hypersensitivity reaction to a specific allergen. However, local allergic conditions cannot be diagnosed with SPTs. Local specific IgE production was only presented before in mucosal tissues. We present a patient with house dust mite sensitization that had variable SPTs results in different body regions.
Subject(s)
Humans , Body Regions , Hypersensitivity, Immediate , Immunoglobulin E , Mast Cells , Mucous Membrane , Pyroglyphidae , SkinABSTRACT
Objective] The treatment of pediatric asthma in remission period is summarized from the positive and negative aspects, in order to provide new ideas and methods for clinical treatment. [Methods] By consulting the related literatures on the traditional Chinese medicine treatment of children with asthma in remission phase, the paper mainly summarized the different physicians' understanding of pathogenesis and approaches to the treatment of pediatric asthma in remission stage. [Results]The treatment of physicians for pediatric asthma in remission phase can be divided into asthenia healthy qi and sthenia pathogenic factor syndrome.The treatment of healthy qi deficiency mainly includes treating lung,spleen,kidney seperately;curing lung-spleen,lung- kidney, spleen-kidney ;treating three viscera meanwhile.The therapy of pathogenic excess contains treating wind,phlegm,stasis respectively;curing phlegm-stasis. [Conclusion]The treatment of traditional Chinese medicine for pediatric asthma has a unique advantage in improving children's physique, reducing the frequency of asthma attacks, and improve children's life quality which has significant clinical effect.
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SCNP( single cell network profiling) assay can depict the characters of signal pathway network without isolating the dif-ferent cells in advance in complex tissues. It will promote the disease mechanism elucidating, disease classification, diagnosis, and therapeutic regimen at cell level. Drug screening and ration-al personalized treatment will also be improved.
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This essay collects relative description on amenia in “Internal Classic” and explores its causa morbi, mechanism, diagnosis and treatment, also expounds the different methods to two types of amenia caused by blood stagnation and dry blood.