Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma / Journal of the Korean Cancer Association, 대한암학회지

Cases of phenotypic heterogeneity of cells within tumors have recently been reported. Here, we report on a patient with characteristic intra-tumor double primary metastases in the lung. This patient was a 40-year-old Korean woman who had been diagnosed with breast cancer (T1N0M0, estrogen receptor/progesterone receptor/HER2 +/+/+) and papillary thyroid cancer three years prior and underwent a complete surgical resection followed by appropriate adjuvant treatment with radiation, hormone, and radioactive iodine. She was recently admitted for newly developed pulmonary nodules. Metastasectomy through video-assisted thoracoscopic surgery revealed recurrent double primary cancer with two different components (metastatic ductal carcinomas from the breast and metastatic papillary carcinomas from the thyroid gland) in each pulmonary nodule in the right upper lobe and right middle lobe. To the best of our knowledge, this is the first report of simultaneous recurrent double metastasis in one organ from different primary origins.

A Case of Frontal Ganglioglioma Coincidence with Pituitary Adenoma

A case of frontal ganglioglioma coexisting with pituitary adenoma is reported. A 37-year-old male presented with chief complaint of headache for 2 months. A neurological examination of the patient revealed no deficit. Brain MRI showed a well enhanced lobulated mass on left frontal lobe and another homogeneously enhanced mass on intrasellar and suprasellar portion. The frontal mass was grayish in color and rubbery hard in consistency on operative field, having relatively good boundary from the adjacent normal brain tissue. The sellar mass was 3X3cm in size and compressed optic chiasm. Histological diagnosis of frontal mass was ganglioglioma and sella mass showed typical features of pituitary adenoma.

A Case of Early Esophageal Cancer Associated with Invasive Thymoma / 대한소화기내시경학회지

Metachronous double cancer of primary early esophageal squamous cell carcinoma and invasive thymoma is a very rare condition. The invasive thymoma had been detected during the myathenia gravis evaluation and treated by radiation therapy 5 years ago. The esophageal lesion had a nodular-surfaced flat elevation at the mid-esophagus that was found by esophagoscopy. Radical resection for the lesions was undertaken after histologic confirmation. Postoperative pathologic examination documented that the esophageal squamous cell carcinoma was in the "early" stage involving the mucosal and submucosal layer only. We report a case of early esophageal cancer associated with invasive thyrnoma with literatures review.