1.
Journal of Leukemia & Lymphoma
;
(12): 626-629, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-461994
ABSTRACT
Double-hit B cell lymphoma refers to a group of mature B cell lymphoma presented with MYC/8q24 rearrangement with one or more concurrent chromosomal translocations.The first and most common translocation ever found is t(14;18)(q32;q21) involving BCL2.Other breakpoint types include MYC+/ BCL2+/BCL6+,MYC+/BCL6+,CCND1+/MYC+,BCL3+/MYC+ et al.This article reviewed the recent publications about the double-hit B cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma.The contents of the review include epidemiology,clinical characteristics,histopathology,treatment,prognosis and some prospects for future work.