ABSTRACT
Objective To investigate the clinical effects and mechanism of naloxone treatment in drowing children.Methods A total of 97 drowing children were divided into treatment group(n=45)and control group(n=52)depending on whether the naloxone was administrated.General treatment was adopted in two groups.Treatment group Was given naloxone.The clinical effects were observed and the levels of betaendorphin(β-EP)in blood plasma were measured with radioimmunoassay(RIA)before and after treatment respectively.Results The total effective rate of treatment group(93.3%,42/45)Was significantly higher than that of control group(76.9%,40/52)(P＜0.05).As compared with that of control group(65.0%,26/40),nervous system disability rate in treatment group(33.3%,14/42)decreased significantly(P＜0.01).Continuous days of poor blood circulation,abnormal respiratory rhythm,convulsion and coma in treatment group were significantly shorter than those of control group respectively(P＜0.01).The level of β-EP was significantly lower in treatment group than that of control group(t=17.1,P＜0.01).Conclusion Clinical use of naloxone in the drowing children has curative result by reducing the level of blood plasma β-EP.
ABSTRACT
the largest value of postmortem submersion and control group)were found in the lung sample The main species of diatoms found in the water sample and drowninga nimals were the same; 3.There was no significant difference of diatom both quantitative and qualitative between postmortem submersion and control group;4. There was no diagnostic value of the diatom analysis for the liver or kidney. A favorable result was obtained in a case of drowning victim of human being submerged in the reservoir for two days examined by the same method,it showed that the conclusionof our study could be used in the forensic medicine practice