ABSTRACT
Theory of Chinese materia medica (CMM) nature was an important part in traditional Chinese medicine (TCM) theoretical system. During the long term practice, based on TCM theories of yin and yang, five elements, zang-fu, meridian and treatment principle, herbal features and patients' reactions were highly summarized into recognition and understanding. Since ancient time, theory of CMM nature has always guided the accurate syndrome differentiation and medication in TCM clinical practice. It contributed to the healthcare and reproduction of Chinese people. Theory of CMM nature is the basic theoretical knowledge which must be mastered in the study and research. Its concepts contained four-qi, five tastes, channel tropism, ascending and descending, toxicity, tonification and reducing, moisture and dryness, smooth and astringent, softness and hardness, fixed and itinerant effect, strong and mild. Using fixed and itinerant effects in the summarization of CMM function is one of the components in CMM nature theories. Although discussions on this theory from practitioners during past dynasties were in disorder, the significant guidance in herbal interaction mechanism and prescription compatibility should not be ignored.
ABSTRACT
OBJECTIVE:To investigate the effects of water extracts of Panax ginseng(warm),dry P.ginseng(mild),P.quinque folium(cool) on the apoptosis of SH-SY5Y cells induced by ?-amyloid protein(A?25-35).METHODS:SH-SY5Y cells were treated with A?25-35 to simulate the pathologic neuronic damage model in patients with Alzheimer's disease,and then treated with different doses of water extracts of P.ginseng(WERG),dry P.ginseng(WEG)or P.quinque folium(WEAG).The morphologic changes of the SH-SY5Y cells were observed by inverted microscope.Cell survival rate was measured by MTT assay.The percentage of apoptosis and the expression of Bax and Bcl-2 proteins were detected by Western Blotting.RESULTS: After treatment with A?25-35 50 ?mol?L-1 for 72 hours,SH-SY5Y cells became more round and aggregated and the cell survival rate was significantly reduced(P
ABSTRACT
The physicochemical environment and action are similar between the traditional decoction and the extract technics with water or alcohol in the production of Chinese patent drug. Different heating time inevitably differs Chinese patent drug from its decoction; and the alteration of extracting dissolvent make great changes in the chemical constitution. All these lead to the change in the nature of a Chinese patent drug. The authors hold that it is difficult to embody exactly the aim of the prescription of Chinese drug in the existing production technology of Chinese patent drug. It is necessary to advance innovative thoughts of adopting modern technology to extract effective ingredients from single Chinese drug and in the reference of traditional decoction, recombining the composition and dosage of Chinese patent drug.