1.
Journal of International Oncology
;
(12): 860-863, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-397350
ABSTRACT
Thermochemotherapy by drug-loaded magnetic micro/nano-particles is attracting increasing attention because it combines the advantages of chemotherapy and high targeting and selectivity of hyperthermia,especially intra-cellular hyperthermia.Magnetic micro/nano-particles,usually consisting of biodegradable pely-mers matrics co-incorporated with ferromagnetic particles and anti-cancer drugs,will generate heat when exposed to an externally applied alternating magnetic fields due to electromagnetic induction by ferro-particles,in the meanwhile,sensitivity of anti-cancer drug will be greatly enhanced by higher temperature.Tumors will greatly suppressed by the synergetic effect of chemotherapy and targeted hyperthermia.