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Objective To explore the effect of self-made Runfei Jianpi Yishen Decoctionin in the treatment of refractory asthma in children,and its influence on pulmonary function,inflammatory factors and clinical symptom score.Methods 88 children with refractory asthma admitted to our hospital from February 2015 to December 2016 were retrospectively selected and divided into control group and observation group according to different treatment methods.The control group was treated with routine western medicine,while the observation group was treated with self-made Runfei Jianpi Yishen Decoction on the basis of the control group.The changes of pulmonary function,clinical symptom score and cytokine levels in two groups were observed.Results The scores of clinical symptoms in the two groups were improved after treatment,and those in the observation group were better than those in the control group (P ＜ 0.05).After treatment,the levels of forced vital capacity (FVC),forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) in the two groups were higher than those before treatment.The levels of FVC,FEV1 and PEF in the observation group were higher than those in the control group (P ＜ 0.05).After treatment,the levels of interleukin (IL)-8,IgE,osteopontin (OPN) and eosinophil cationic protein (ECP) in the two groups were decreased,while the levels of interferon (IFN)-γand Cor were increased (P ＜ 0.05).After treatment,the levels of IL-8,IgE,OPN and ECP in the observation group were lower than those in the control group,and the levels of IFN-γ and Cor in the observation group were higher than those in the control group (P ＜ 0.05).Conclusions The self-made Runfei Jianpi Yishen Decoctionin is effective in the treatment of refractory asthma in children.It can effectively improve the pulmonary function and regulate the levels of immune factors,OPN and ECP in children.
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Objective To investigate the effect and significance of Jiangu granule on the expression of aquaporin 3 (AQP3) in articular cartilage of knee osteoarthritis (OA) rats.Methods Sprague-Dawley (SD) rats were randomly divided into sham operation group, model group, and Jiangu granule treatment group.The treatment group was divided into Jiangu granule high dose, medium dose, and low dose groups, with 12 rats in each group.The osteoarthritis model was made by injecting 4％ papain and 0.03 mol/L Lcysteine mixture into the knee joint.Sham-operated group and model group received normal feeding every day.Treatment group (high, medium, and low dose groups), the next day after the completion of the mod el, were given different dose Jiangu granule by gavage twice a day for 4 weeks.After treatment, the ratswere executed uniformly, using general optical microscope and the pathological section of histology to observe the articular cartilage damage.The expression of AQP3 in articular cartilage of rats was detected by real time polymerase chain reaction (RT-PCR) and Western blot.Results The articular cartilage destruction of Jiangu granule treatment group was significantly less than that of the model group (P ＜ 0.05).The mRNA and protein expression levels of AQP3 in model group was significantly higher than that in the sham operation group (P ＜ 0.05).OA rats with Jiangu granule after 4 weeks treatment, the mRNA and protein expression levels of AQP3 in articular cartilage were decreased significantly.Jiangu granule in each sub group relative to the model group had statistical significance (P ＜ 0.05), and the high dose group was decreased significantly.Conclusions Jiangu granule can reduce the expressions of AQP3 in OA articular cartilage of rats and alleviate the swelling of joints, which may have protective effects on articular cartilage.
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Objevtive To investigate the efficacy of Xuebijing injection combined with Ulinastatin for acute pancreatitis.Methods Databases were searched,like Pubmed,Embase,Cochrane Central Register of Controlled Trials (CENTRAL),China Biology Medicine disc (CBM),China National Knowledge Infrastructure (CNKI),Cochrane library,and Wangfang for randomized controlled trial (RCT) about the treatment of Xuebijing injection combined with Ulinastatin for acute pancreatitis.After evaluating the quality of literatures objectively,data were analyzed by RevMan 5.0 software.we evaluated abdominal pain relief time,recovery time of blood amylase,recovery time of white blood cell (WBC),concentration of interleukin (IL)-6,IL-8,tumor necrosis factor α (TNF-o) and total effective rate.Results Eleven studies and 893 patients were accepted into this article.Meta-analysis showed that abdominal pain relief time [weighted mean difference (WMD) =-1.71,95 ％ CI:-2.21,-1.21,P ＜ 0.01],recovery time of blood amylase (WMD =-1.82,95 ％ CI:-2.39,-1.25,P ＜ 0.01),recovery time of WBC (WMD =-2.75,95 ％ CI:-3.19,-2.31,P ＜ 0.01),and hospital stay time (WMD =-5.99,95 ％ CI:-7.73,-4.26,P ＜ 0.01)in experimental group was better than control group.Compared to control group,on the seventh day after treatment,inflammatory cytokines,including IL-6 [standardized mean difference (SMD) =-1.09,95％ CI:-2.66,0.48,P=0.17],IL-8 (SMD=-1.02,95％ CI:-1.66,-0.38,P＜0.01),andTNF-α (SMD =-1.10,95％ CI:-1.68,-0.53,P ＜ 0.01) were lower.In experimemal group,total effective rate was better than the control group (RR =1.16,95％ CI:1.07,1.25,P=0.0002).Conclusions Xuebijing injection combined with Ulinastatin for acute pancreatitis was more effective than traditional basal treatment or using Ulinastatin alone.However,the literature quality were mediocre,we need more large,random,double blind,and polycentric clinical study to prove further.