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Objective Tocomparetheefficacybetweenstentingandmedicationinpatientswith vertebralarteryoriginstenosis.Methods Theclinicaldataof82patientswithmoderatetoseverevertebral artery origin stenosis (stenosis rate >50%)from January 2011 to January 2013 were analyzed retrospectively. They were divided into either a stent+medication group (n=40)or a medication group (n=42)according to the different treatment methods. The degree of vascular stenosis,restenosis rate,incidence of cerebral ischemic events,and National Institutes of Health Stroke Scale (NIHSS)of the patients for DSA reexamination at one year were documented,and comprehensive analysis were conducted. Results (1 )44 stents were implanted in 40 patients,1 of the patients still had residual stenosis of 60% because of the stenosis plaque was harder despite twice balloon dilations. No serious perioperative complications occurred. The success rate of the operation was 97. 5%. The vascular stenosis rate of vertebral artery origins in patients of the stent+medication group was improved significantly,and decreased from 73 ± 13% to median 11%(8%,50%)at one year after stenting. (2)After 1 year,11 patients (27. 5%)had in-stent restenosis in the stent +medication group,including 2 patients (5%)had stent fracture at the same time. Four patients (9. 5%)in the medication group had complete occlusion of vertebral artery,but only 2 had corresponding clinical symptoms. (3)There was no significant difference in the NIHSS scores after the treatment between the stent+medication group and the medication group (Z=1. 678,P=0. 093). The total ischemic events in patients of the stent+medication group was 7 (17. 5%),compared with the incidence of ischemic events in 16 patients (38. 1%)in the medication group,there was significant difference (χ2 =4. 306, P=0.038).Conclusion Stentingissafeandeffectiveforpatientswithvertebralarteryoriginstenosis.It may significantly improve vertebral stenosis,and it is better than medication alone for preventing the occurrence alone of the posterior circulation ischemic events,however,the high in-stent restenosis rate for vertebral artery origin stenosis is still an important problem to be solved.
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Objective To evaluate the clinical efficacy of a1 receptor blocker (ARB) in treating voiding symptoms after TUVP and investigate its mechanism.Methods A total of 80 patients with BPH were randomly divided into 2 groups (40 cases for each).The patients in treatment group were given α1 receptor blocker at 1 day after TUVP for 30 days,while patients in control group did not receive ARB treatment.The indices such as Qmax,BRU,IPSS and QOL before operation versus 30 days after operation were monitored and analyzed.The therapeutic effect was compared between 2 groups.Results The changes of Qmax,IPSS,QOL and BRU after α1 receptor blocker treatment had significant difference between the two groups [(20.35 ± 1.62)ml/s,(11.25± 5.02)ml,(4.91 ± 1.30)scores,(1.13±0.30) scores vs.(3.92±1.20)ml/s,(529.24±7.19)ml,(31.33±2.56) scores,(5.48±0.42) scores,all P＜ 0.05].All the data of treatment group showed significant improvement compared with those of control group.Conclusions The α1 receptor blocker was effective in treating voiding symptoms after TUVP.
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Acne is divided into the patterns of wind and heat in the lung meridian and accumulation of dampness and heat. Forty cases of acne were treated by acupuncture plus herbal drugs (acupuncture and drug group, A) and 30 cases were treated by simple acupuncture as the control group (acupuncture group, B). The results showed basic cure in 31 cases, remarkable effect in 5 cases, effect in 3 cases, failure in 1 case and the total effective rate of 97.5% in Group A, and basic cure in 16 cases, remarkable effect in 6 cases, effect in 3 cases, failure in 5 cases and the total effective rate of 83.3% in Group B. There was no significant difference ( P > 0.05 ) in the therapeutic effect and there was a significant difference (P < 0. 01 ) in the curative rate in the two groups. The therapeutic effect was obviously better in Group A than in Group B.
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Objective To study the inhibition effects of 10-hydroxycamptothecinc and low molecular weight heparins on human hepatocellular carcinoma(HCC)in nude mice.Methods Metastatic model of HCC was established in nude mice.The model mice were randomly divided into 4 groups:the control group,10- hydroxycamptothecinc group,low molecular weight heparins group,and combined treatment group(10-hy- droxycamptothecinc and low molecular weight heparins).Tumor sizes,tumor inhibition rates,tumor metas- tases,intratumoral microvessel density(MVD),CD_(31)and AFP were evaluated.Results In comparison with the control group and the 10-hydroxycamptothecinc group,the tumor sizes of the low molecular weight heparins and the combined treatment group were significantly smaller;the tumor inhibitor rates were 0 versus 76.6%, 79.8%,94.1%;MVD were 21.1?6.5 versus 17.2?3.1,7.1?2.3 and 4.8?1.8;CD_(31)were 31.7?6.1 versus 26.2?5.2,20.9?4.7 and 19.5?2.4;the incidence of liver metastasis was 80% versus 70%,20% and 10%;lung metastasis was 70% versus 60%,20% and 10%;the peritoneal metastasis was 90% versus 60%,30% and 30%.AFP were(121.9?31.4)ng/ml versus(56.2?37.9)ng/ml,(75.6?28.7)ng/ml and(20.7?12.9)ng/ml. Inhibiting effects of growth and metastasis of HCC in 10-hydroxycamptothecinc group,low molecular weight heparins group and combined treatment group were significantly different from those of the control group(F= 9.074,P
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The abnormality of the central noradrenergic system in Alzheimer's disease has two cases: decrease or increase. The former is easy to be understood, because it is resulted from the outstanding forfeit of the noradrenergic neurons in the nucleus locus ceruleus (nLC); but the noradrenalin concentration does not change and enen increase, it seems to disagree with the loss of the noradrenergic neurons in the nLC. This article put emphasis on it, enumerated the related evidence and analyzed the possible causes. At present time, the drugs to increase noradrenalin is used mostly in clinic. This paper summarized it and put forth our own opinions.
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Objective To observe the effect of haishengsu preparation extracted from Tegillarca granosa on patients with NSCLC and renal cancer that lose the opportunity of operation, radical cure or large dose chemotherapy. Methods 61 cases of NSCLC and 27 cases of renal cancer patients received the haishengsu injection 2.4mg+0.9%NaCl 250ml iv once daily for a consecutive 20 days. 28 days was considered one treatment cycle and each case received 3 to 6 cycles respectively.Results In NSCLC patients,2 cases completely remitted (CR), 28 cases of partially remitted (PR) with the total effective rate of 49.18%. Curative effects in cases with initial treatment, IIIb stage, adenocarcinoma or high behavior condition were higher than those of cases with retreatment, Ⅳ stage, squamous carcinoma, or low behavior condition respectively (P