ABSTRACT
Objective:To investigate the effect of the production process of Zushima Guanjie Zhitong Gao from solvent method to hot-pressed method on <italic>in vitro</italic> kinetic behavior of this preparation. Method:Solvent and hot-pressed methods were used to prepare three batches of samples above pilot scale， and <italic>in vitro</italic> release and percutaneous penetration of the index components （7，8-dihydroxycoumarin and methyl salicylate） in Zushima Guanjie Zhitong Gao were investigated by modified Franz diffusing cells. Result:The contents of 7，8-dihydroxycoumarin and methyl salicylate in Zushima Guanjie Zhitong Gao prepared by solvent method were 73.72， 494.67 μg/patch， and their contents in hot-pressed method samples were 159.21， 2 638.99 μg/patch， respectively. In the solvent method samples， the average cumulative release amounts of 7，8-dihydroxycoumarin and methyl salicylate in 24 h were 2.04， 12.21 μg， and their average cumulative release amounts in 24 h of hot-pressed method samples were 2.16， 36.24 μg， respectively. In the solvent method samples， the average cumulative permeation amounts of 7，8-dihydroxycoumarin and methyl salicylate in 24 h were 0.38， 2.79 μg， and they were 0.40， 7.49 μg in hot-pressed method samples. The cumulative release and permeation amounts in 24 h of 7，8-dihydroxycoumarin in the hot-pressed method samples were basically the same as those of the solvent method samples， but the cumulative release and permeation amounts in 24 h of methyl salicylate in the hot-pressed method samples were significantly higher than those of the solvent method samples （<italic>P</italic><0.05）. Conclusion:The retention of 7，8-dihydroxycoumarin and methyl salicylate by hot-pressed method is better than that of the solvent method. The process change has no significant effect on the <italic>in vitro</italic> kinetics of 7，8-dihydroxycoumarin in Zushima Guanjie Zhitong Gao， however， after the change from the solvent method to the hot-pressed method， the methyl salicylate in this preparation has a higher cumulative release and permeation amounts.
ABSTRACT
ABSTRACT: The macaw palm has been identified as a prime feed stock for biodiesel industries in the near future coming decades. However, there are no machines for harvesting and detaching fruits in the biofuel industry; hence, the study of the dynamic behavior of the fruit-rachilla system would aid in the development of such machines. Thus, this study seeks to determine the modulus of elasticity and the damping ratio of four different plant accessions obtained from the Active Germplasm Bank of the Universidade Federal de Viçosa (UFV). Tensile testing was conducted to determine the modulus of elasticity. From the graphical results of tension versus specific strain, it was possible to determine the modulus of elasticity by using the tangent method. To determine the damping ratio, the logarithmic decrement method was performed using vibration testing. Vibration test consisted of a generated impulse of 100% of the amplitude of acceleration that was used to excite the system. The acquisition of the generated information was performed by a piezoelectric accelerometer. The average modulus of elasticity ranged from 2.22 to 3.17MPa, and the average damping ratios ranged from 0.04 to 0.08. Thus, the macaw fruit-rachilla was an under-damped system.
RESUMO: A macaúba tem sido apontada como uma das principais matérias-primas para a indústria de biodiesel nas próximas décadas. No entanto, não existem máquinas para colheita ou destacamento dos frutos na usina e o estudo do comportamento dinâmico do sistema fruto-ráquila nortearia o desenvolvimento dessas máquinas. Dessa forma, objetivou-se determinar o módulo de elasticidade e a razão de amortecimento de quatro acessos provindos do Banco Ativo de Germoplasma da UFV. Foi realizado teste de tração para determinar o módulo de elasticidade. A partir dos resultados obtidos na forma gráfica, tensão versus deformação específica, foi determinado o módulo de elasticidade pelo método da tangente. Para determinar a razão de amortecimento, foi empregado o método do decremento logarítmico, realizado por meio de teste de vibração. O teste de vibração constituiu-se de um impulso para excitar o sistema. A aquisição das informações geradas foi realizada por meio de acelerômetro piezelétrico. O módulo de elasticidade médio ficou entre 2,22 e 3,17MPa e as razões de amortecimento médias ficaram entre 0,04 e 0,08. Concluiu-se que o sistema fruto-ráquila da macaúba é subamortecido.