ABSTRACT
Objective To study the application of dynamic ultrasound countercurrent extraction technology in industrialization of Lianhua Qingwen Capsule by multi-index optimization. Methods Ultrasonic temperature and ultrasonic time were investigated by using single factor design. The three factors of dry extract yield, the active ingredient content, and fingerprints were selected as the optimization indexes to investigate the solvent consumption and extraction time between the dynamic ultrasound countercurrent extraction process and the original reflux extraction process under the fixed conditions of process parameters. Results Compared with traditional reflux extraction technology, dynamic ultrasound countercurrent extraction technology effectively reduced the alcohol consumption and saved extraction time on the basis of guarantee of the active ingredient content. Conclusion Dynamic ultrasound countercurrent extraction process, with simple and fast advantages, can be used to Lianhua Qingwen Capsule production, which can significantly reduce production costs and increase productivity.
ABSTRACT
PURPOSE: To evaluate the usefulness of dynamic ultrasound assessment for the diagnosis of DDH and for Pavlik harness treatment monitoring. MATERIALS AND METHODS: Dynamic ultrasound examination was performed on 35 infants (average age: 3 months) having possible hip dysplasia. Based on ultrasonographic findings (normal, laxity with stress, subluxated, dislocated), the indication and duration of Pavlik harness treatment was determined. Radiographic examinations were performed at regular intervals (after 6 months) to assess hip development. RESULTS: All hips showing normal ultrasonographic findings developed well. In 20 infants treated with the Pavlik harness, 2 infants failed to maintain the harness application, 16 infants among 18 were successfully weaned from the harness, and 2 infants required additional treatment. Of the 16 successfully treated patients, 3 showed hip dysplasia, and one showed mild avascular necrosis of the femoral head. CONCLUSIONS: Dynamic ultrasound monitoring is an effective method for the accurate diagnosis of various degrees of hip dysplasia, the assessment of reduction quality, and for the assessment of hip stability during Pavlik harness treatment, and provides a reliable guide during the weaning from the harness process.