Anti-motion Artifact Performance Test System for Ambulatory ECG Monitoring Equipment / 中国医疗器械杂志

Anti-motion artifact is one of the most important properties of ambulatory ECG monitoring equipment. At present, there is a lack of standardized means to test the performance of anti-motion artifact. ECG simulator and special conductive leather are used to build the simulator, it is used to simulate human skin, to generate ECG signal input for the ECG monitoring equipment attached to it. The mechanical arm and fixed support are used to build a motion simulation system to fix the conductive leather. The mechanical arm is programmed to simulate various motion states of the human body, so that the ECG monitoring equipment can produce corresponding motion artifacts. The collected ECG signals are read wirelessly, observed, analyzed and compared, and the anti-motion artifact performance of ECG monitoring equipment is evaluated. The test results show that by artificially creating the small difference between the two groups of ambulatory ECG monitoring equipment, the system can accurately test the interference signals introduced under the conditions of controlled movement such as tension and torsion, and compare the advantages and disadvantages. The research shows that the test system can provide convenient and accurate verification means for the research of optimizing anti-motion interference.

Fetal ECG Detection System Based on WiFi Data Transmission / 中国医疗器械杂志

Fetal ECG monitoring is a routine clinical detection method that can reflect the changes of fetal heart in utero in real time. At present, most of the clinical fetal heart rate detection adopts the ultrasonic Doppler method, which is technically difficult and highly specialized in operation and expensive. This study introduces a fetal ECG detection system based on the maternal abdominal electrode method. The weak fetal ECG changes are sensed through the maternal abdominal electrode, and the mixed ECG signal is obtained through the corresponding amplification and filtering circuit. Finally, the obtained signal is passed through WiFi, transmitted to the host computer. The host computer uses the adaptive filtering algorithm to estimate the fetal ECG signal. The system has strong feasibility, low operation expertise, low cost, and is more convenient.

Research and Implementation of 433 MHz-based Wireless Implantable Pacing System / 中国医疗器械杂志

In order to solve the problem of communication interference and communication distance caused by the rapid pacing system when establishing the rapid atrial fibrillation model, a low-power implantable pacing system based on 433 MHz communication frequency to form a star network is designed. The system includes an implantable pacemaker, a programmer head, and programmer software. The pacemaker is composed of a wireless communication module, a pacing module, an ECG monitoring module, and a power management module. The programmer head acts as an intermediate node in the star network and is controlled by PC programmer software to program each pacemaker. This article introduces the hardware design and software flow of each part of the system, and describes the results of in vivo simulation and in vivo animal models of the system. The results show that the designed system and application method are effective and feasible for the rapid atrial pacing atrial fibrillation model. 433 MHz wireless communication, implantable, pacemaker system, low-power, ECG monitoring.

Design and Implementation of the Wireless ECG Monitor Based on AD8232 and CC2530 / 中国医疗器械杂志

Based on the heart rate monitor front end AD8232 chips and Zigbee system solutions CC2530 single chip, the wireless ECG monitor has been realized in order to implement the acquisition, processing and wireless transmission of electrocardiogram signal. Meanwhile, the real-time heart rate has been calculated and wirelessly transmitted. The wireless ECG monitor is characterized by low power consumption, small size and simple operation. It can be seen from the experimental results that the wireless ECG monitor designed in this paper can successfully obtain favorable ECG data and real-time heart rate data and display it.

Design of wearable multi-parameter monitor / 医疗卫生装备

Object To develop a wearable multi-parameter monitor to facilitate cardiac monitoring of the aged.Methods The monitor had MSP430F5529 micro controller as the core unit, which realized physiological signals acquisition, transmission and storage with ADS1292R chip 2-channel analog front-end to acquire ECG and respiratory signals, ADXL345 sensor to collect postural information, and Bluetooth 4.0 module to send the acquired data to the intelligent mobile terminal and store them in TF card.Results The developed monitor had the continuous working time being 24 hrs, and provided auxiliary diagnosis by monitoring ECG, respiration and posture parameters.Conclusion The monitor behaves well in small size and high wearability, and gains prospects in ECG monitoring in the field of mobile medicine.

Design of ECG Monitoring Analyzer Based on MicrocontrollerCC2530 / 中国医疗器械杂志

<p><b>OBJECTIVE</b>A remote wireless electrocardiogram (ECG) monitoring system is designed by using the CC2530 micro-controller as the device core.</p><p><b>METHODS</b>Acquisition, conversion and data processing for ECG signals are realized on CC2530 micro-controllers. And the ECG data is transmitted to the coordinator by using ZigBee. It realizes the real-time monitoring of ECG signals and heart rate variability (HRV) data.</p><p><b>RESULTS</b>The test results show that the maximum error of the designed ECG monitoring analyzer is 3 beats per minute and the average error is 1.6 beats per minute, which can meet the requirement of pharmaceutical industry standards of the People's Republic of China.</p><p><b>CONCLUSIONS</b>The ECG monitoring analyzer has good portability, high measurement precision and good practical application values.</p>

Design and implementation of remote ECG monitoring system-server program / 医疗卫生装备

Objective To build a server to receive ECG data from the smart phone through remote network transmission,which has the functions of data storage,painting ECG waveform at real time,browsing historical waveform,preliminary ECG self-diagnosis and etc.Methods The development was executed with C# language in Visual Studio 2013,which used the socket for network transmission,GDI for waveform painting,Dataset/Datareader for data access as well as thread for multithreaded programming etc.Five-point smoothing filter was applied to ECG signal preliminary processing,and classical difference threshold algorithm was used to implement waveform analysis of ECG data.The main QRS waves were detected,and ECG features such as R-R interval were analyzed to form ECG self-diagnosis report.Results The server received and showed the ECG data transmitted by smart phone successfully,and then generated ECG waveform and self-diagnosis report.Conclusion This server has a great performance on receiving the data from portable facilities.In addition,it also performs well and stably in accessing and showing ECG data.

Design implementation and of ECG monitoring and management system based on smartphone platform / 医疗卫生装备

Objective To develop an ECG monitoring and management system based on the smartphone platform to transmit ECG data to the doctor in daily life or working environment.Methods The system was composed of an ECG signal acquisition device and a smartphone App.The ECG signal acquisition device used MSP430F149 microcontroller as the core unit,which executed ECG signal extraction by adopting right leg drive,active filters,dual instrumentation amplifier and moving average algorithm,applied differential threshold method to accurately detecting R wave,calculated heart rate and then sent ECG data to the smartphone through Bluetooth 4.0 module.The smartphone App was developed based on cross-platform mobile development framework Cordova,and used Cordova plugins,JavaScript,HTML5 and CSS to receive the data from the acquisition device,draw and store ECG,show heart rate and remind abnormalities in heart rate as well as to transmit ECG data to the doctor through the mobile medicine App and social App.Then the doctor provided advices on prevention,treatment and etc after analyzing the received data.Results Compared with the ECG machine,the system had the relative errors of heart rate,P duration,QRS duration and QT duration being 2.7％,4.5％,4.3％ and 3.3％ respectively.All the above four parameters having significant correlations,and the correlation parameters were 0.955,0.948,0.91 and 0.834 respectively (P＜0.05).The system had 8-h endurance in case of being fully charged.Concluslon The system gains advantages in power consumption,accuracy,noise,cost,volume,weight,safety,reliability as well as easy operation and maintenance,and facilitates the ECG conditions to be mastered timely by the doctor.

Clinical observation and psychological intervention on the treatment of severe heart failure by pumping vasoactive drugs under ECG monitoring / 中国生化药物杂志

Objective To analyze the clinical observation and psychological intervention of the vasoactive drugs in the treatment of severe heart failure under ECG monitoring. Methods 100 patients with severe heart failure treated in our hospital from February 2015 to August 2016 were selected as the research object. They were randomly divided into the control group and the experimental group, with 50 patients in each group. The control group was treated with conventional treatment, including oxygen therapy and cardiac and diuretic therapy, the experimental group were given ECG monitoring and infusion of vasoactive drug therapy, using sodium nitroprusside drugs, and psychological intervention on the mental status of patients, strengthen communication and exchanges with patients, increasing confidence in treatment and the treatment compliance of patients. The clinical indexes of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the number of invalid cases in the experimental group was 5 cases, the number of effective cases was 30 cases, and the number of effective cases was 15 cases. The number of invalid cases in the control group was 9 cases, the effective number was 27 cases, and the effective cases were 14 cases. The effective rate of treatment in the experimental group was 90%, which was significantly higher than that in the control group, and the effective rate was 82%, with statistical difference (P<0.05). There were no obvious adverse reactions in the experimental group and the control group. Conclusion The application of vasoactive drugs under ECG monitoring in the treatment of severe heart failure has better clinical efficacy and higher safety.

Design implementation and of ECG monitoring and management system based on smartphone platform / 医疗卫生装备

Objective To develop an ECG monitoring and management system based on the smartphone platform to transmit ECG data to the doctor in daily life or working environment.Methods The system was composed of an ECG signal acquisition device and a smartphone App.The ECG signal acquisition device used MSP430F149 microcontroller as the core unit,which executed ECG signal extraction by adopting right leg drive,active filters,dual instrumentation amplifier and moving average algorithm,applied differential threshold method to accurately detecting R wave,calculated heart rate and then sent ECG data to the smartphone through Bluetooth 4.0 module.The smartphone App was developed based on cross-platform mobile development framework Cordova,and used Cordova plugins,JavaScript,HTML5 and CSS to receive the data from the acquisition device,draw and store ECG,show heart rate and remind abnormalities in heart rate as well as to transmit ECG data to the doctor through the mobile medicine App and social App.Then the doctor provided advices on prevention,treatment and etc after analyzing the received data.Results Compared with the ECG machine,the system had the relative errors of heart rate,P duration,QRS duration and QT duration being 2.7％,4.5％,4.3％ and 3.3％ respectively.All the above four parameters having significant correlations,and the correlation parameters were 0.955,0.948,0.91 and 0.834 respectively (P＜0.05).The system had 8-h endurance in case of being fully charged.Concluslon The system gains advantages in power consumption,accuracy,noise,cost,volume,weight,safety,reliability as well as easy operation and maintenance,and facilitates the ECG conditions to be mastered timely by the doctor.

Clinical observation and psychological intervention on the treatment of severe heart failure by pumping vasoactive drugs under ECG monitoring / 中国生化药物杂志

Objective To analyze the clinical observation and psychological intervention of the vasoactive drugs in the treatment of severe heart failure under ECG monitoring. Methods 100 patients with severe heart failure treated in our hospital from February 2015 to August 2016 were selected as the research object. They were randomly divided into the control group and the experimental group, with 50 patients in each group. The control group was treated with conventional treatment, including oxygen therapy and cardiac and diuretic therapy, the experimental group were given ECG monitoring and infusion of vasoactive drug therapy, using sodium nitroprusside drugs, and psychological intervention on the mental status of patients, strengthen communication and exchanges with patients, increasing confidence in treatment and the treatment compliance of patients. The clinical indexes of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the number of invalid cases in the experimental group was 5 cases, the number of effective cases was 30 cases, and the number of effective cases was 15 cases. The number of invalid cases in the control group was 9 cases, the effective number was 27 cases, and the effective cases were 14 cases. The effective rate of treatment in the experimental group was 90%, which was significantly higher than that in the control group, and the effective rate was 82%, with statistical difference (P<0.05). There were no obvious adverse reactions in the experimental group and the control group. Conclusion The application of vasoactive drugs under ECG monitoring in the treatment of severe heart failure has better clinical efficacy and higher safety.

Strategy discussion of strengthening ECG monitoring in phase I clinical trials of investigational new drugs / 中国药学杂志

OBJECTIVE: To discuss the strategy of strengthening ECG monitoring in phase I study and to provide references for the necessity of thorough QT/QTc study and for the subsequent development strategies. METHODS: Relevant progresses in cardiac safety studies and guidelines of QT/QTc study were referred to in discussing the study strategy. RESULTS: The applicable scope, protocol design and quality control of the strengthening ECG monitoring study have been preliminarily explored. CONCLUSIONS: Based on the phase I clinical trials, cardiac safety of the new drugs is preliminarily evaluated and screened, without increasing drug exposure, and this study during phase I clinical trial will provide basis and reference for the further QT/QTc trial.

Study on the Impacts of remote real-time transmission 12-lead electrocardiogram system on door-to-balloon time in patients with ST-segment elevation myocardial infarction / 中华急诊医学杂志

Objective This study was aimed to evaluate the remote real-time transmission 12-lead electrocardiogram system on door-to-balloon time in patients with ST-segment elevation myocardial infarction.Methods We retrospectively analyzed the consecutive patients with STEM I who had accepted primary percutaneous coronary intervention (PCI) in the chest pain center of our hospital from February 2012 to July 2012.The study group consisted of patients with pre-hospital ECG,while the control group included patients without pre-hospital ECG,Their door-to-balloon time and door-to-catheter room time,mortality w ere compared.Results Totally 60 consecutive patients who had received primary PC I for STEMI were evaluated.Among them,35 patients were hospitalized with pre-hospital ECG while the other 25 patients without ECG.The Pre-hospital ECG was associated with a significautly shorter median door-to-balloon time (38 min vs.94min;P ＜0.01),The proportion of patients received balloon dilation within the guidelinerecommended 90 min timeframes Was significantly higher in pre-hospital ECG group than in non pre-hospital ECG group (94.6％ vs.60％;P =0.001).No difference was observed in mortality between the two groups (5.7％vs.4％;P ＞ 0.05),Significant difference was seen in the median hospital time in study group (5 compared with control group (7day) (5 day vs.7 day;P ＜ 0.01).Conclusions The remote real-time transmission 12-lead electrocardiogram system is associated with a significantly shorter door-to-balloon time in STEMI patients.The remote real-time transmission 12-lead electrocardiogram system is recommended in patients suspected STEMI.

Study of the pre-hospital diagnostic reliability of real-time tele-transmission of 12-lead electrocardiogram of patients with acute ST-segment elevated myocardial infarction / 中华急诊医学杂志

Objective To evaluate the pre-hospital diagnostic reliability of real-time tele-transmission of 12-lead electrocardiogram of patients with ST-segment elevated acute myocardial infarction (STEMI).Methods The 12-lead electrocardiogram was simultaneously recorded with real-time tele-transmission system and a conventional electrocardiograph in 40 STEMI cases.The width and amplitude of each wave,the deviated amplitude of ST-segment in the same leads were compared by t-test and rank-sum test.Results There were no statistical differences in the width and amplitude of P wave,QRS wave and t wave as well as the deviated altitude of ST-segment between the two separate electrocardiographs (P ＞0.05).There was a significant positive correlation between the two ECG devices in respect of ST-segment elevated altitude (r =0.912,P =0.000).The differential ability of ST-segment elevation between two separate ECG devices kept highly consistent (Kappa value:0.976).Conclusions Real-time tele-transmission of 12-lead electrocardiogram is reliable for the pre-hospital diagnosis of STEMI.

Design of intelligent detection system to individual life signs / 中国医学装备

Objective: To achieve intelligent access to normal training or individual soldier signs information during the war, establish individual soldier health intelligent interactive regulation and health system platform of IOT, realized digitalization, information management mode. Methods: Using the communication network, intelligent call, vital signs monitoring technology, to design intelligent signs monitoring system. Results:This system is mainly for the automatic sense of individual signs in the training or war, to understand the individual activity, get the sign data, which can send information through a call or intelligent system, based on the identification and location, medical personnel to care and treatment in the shortest time, construction of intelligent information. Conclusion: Through the use of intelligent detection system to Individual life signs in training or in wartime, the system can always grasp of individual soldier signs, and realizing a complete coverage of all of the intelligent health monitoring system, to provide effective guarantee for wartime workers health.

Mobile network on telemedicine dynamic ECG monitoring system / 医疗卫生装备

Mobile network is used to transmit signals for telemedicine dynamic ECG monitoring system.In this way,ECG monitoring can be performed to patients at all times and places,thus really realizing telemedicine dynamic ECG monitoring.In the paper,the system is studied.The discussion on how to transmit ECG signals and feedback the diagnostic message through mobile network is presented in detail.

ECG monitoring module based on Bluetooth technology / 医疗卫生装备

Objective To realize excellent remote medical treatment for patients.Methods The ECG monitoring module based on Bluetooth technology was designed.The ECG module and Bluetooth radio-frequency module,which possessed the function of data acquisition and simple processing,were connected through data wire to act as ECG terminal.By using C8051F020 and ROK 101 007 Bluetooth module,ECG Bluetooth transmission module read in HCI command through serial port,thus realizing mutual communication.VC++6.0 was used as developing tool to edit remote monitoring server programme running on the computers in monitoring center.Results ECG monitoring module could acquire ECG data in real time and transmit it to personal computers,and then send it to the monitoring center through Wide Band.In this way,real-time information exchange between doctors and users was realized.Conclusion This module makes full use of the advantages of Bluetooth technology and has strong practicability.

Development of Home Health Monitoring System using Digital Telemetry / 대한의료정보학회지

We developed the system that enables patients to be treated at home during their daily life through digital telemetry and public communication line. In this study, video conference based remote examination and wireless telemetry were integrated together to form a remote monitoring homecare system, and underwent the validation. Test ECG signals were transmitted wirelessly unhindering the person's movement in one floor of our building, and the stability was assessed. The signal were transmitted to remote host via ISDN, with the patient's voice and moving image. To control the system and manage files remotely, the interactive model was devised for this study.

Design of mobile ECG monitoring microsystem terminal / 医疗卫生装备

Healthcare at home is accepted little by little with the development of medical service in the community. This paper introduces the design method of mobile ECG monitoring system terminal for healthcare at home. The adoption of active electrode and digital trap contributes to the elimination of the external interference. Low-power-consumption MSP430 micro-controller applied, the realtime acquisition, procession and transmission to PDA of ECG are performed.

Research on ECG Telemonitoring System Based on Virtual Instrument / 医疗卫生装备

Objective To develop an ECG telemonitoring system which can meet many needs of cardiopaths with enjoying medical care out of hospitals.Methods The signals of collection and pretreatment in ECG105 that were transmitted to the computer through serial port,the computer's powerful functions in analyzing and processing signal were utilized fully to design ECG telemonitoring system based on virtual instrument by LabVIEW.Results The system can redisplay and analyze the stored signal and judge whether the heart rate is abnormal,and implement ECG data remote transmission.Conclusion The display,storage,redisplay,diagnosis and tekecommunications of ECG can be achieved conveniently and provide convenience for many cardiopaths with its powerful functions and low cost.