ABSTRACT
【Objective】 To evaluate the efficacy and safety of different doses and frequencies of oral Sildenafil in the treatment of erectile dysfunction (ED). 【Methods】 The randomized,open clinical trial included 120 ED patients who met the inclusion and exclusion criteria. The patients were randomly divided into the following groups:on-schedule (25 mg/day),on-demand (50 mg,taken irregularly half an hour before each sexual life),new regular group (25 mg/day,50 mg more before each sexual life),regular group (100 mg/time,twice/week). All treatments lasted for 8 weeks. The follow-up indexes included the five-item International Index of Erectile Function (IIEF-5),Erection Hardness Scale (EHS) and Sexual Encounter Profile (SEP2/3). The adverse reactions were recorded. 【Results】 The IIEF-5 scores of the four groups were significantly higher than those after baseline treatment (P0.05). In terms of effective rate,at the 16th week,there were significant differences between the on-demand group (10.7%) and new regular group (62.1%),and between the on-demand group (10.7%) and regular group (50.0%) (P<0.001). In terms of EHS, the percentage of grade 4 patients in regular group was significant higher than that in the on-demand group at the 8th week and 16th week (all P<0.05). In terms of positive rate of SEP-3,there was a significant difference between the on-demand group and regular group (P=0.042) at the 16th week. In the course of treatment,there were transient adverse reactions such as headache,blurred vision,stuffy nose and back pain,which did not affect the treatment. 【Conclusion】 All of the four treatment methods of oral sildenafil showed good efficacy. Both regular group and new regular group maintained good clinical efficacy during the follow-up,which is better than that of the on-demand group. The new regular scheme can be used as a new,safe and effective treatment option.
ABSTRACT
Contexte et objectif. La maladie athéromateuse dont la coronaropathie étant une pathologie diffuse peut être prévenue par le contrôle des facteurs de risqué cardiovasculaire. Le but de cette étude était de décrire les caractéristiques pharmaco doppler pénien des patients coronariens souffrant de dysfonction érectile. Méthodes. Il s'agissait d'une série analytique des cas suivie entre juin 2020 et février 2021. Elle concernait des patients ayant des lésions athéromateuses significatives à la coronographie et souffrant de dysfonction érectile. Nous avons évalué les caractéristiques pharmaco doppler pénien. La qualité d'érection était appréciée par le score de rigidité Erectile Hardness Score (EHS). Résultats. Trente-six patients étaient inclus. L'âge moyen était de 56 ± 8,4 ans. le pic de Vitesse systolique au repos (PSVr) moyen des patients était de 13,7 cm/s ± 5,9. Le pic de vitesse systolique post injection (PSV pi) moyen des patients était de 23,9 cm/s ± 5,4. Les causes étaient principalement artérielles de 75%. La qualité d'érection était appréciée selon le score EHS : E1 (83%), E2 (22%), E3 (5%) et E4 (3%). Conclusion. La dysfunction érectile est associée aux facteurs de risque cardiovasculaire selon plusieurs études. L'echodoppler pénien avait occupé une place importante dans le diagnostic étiologique. Les causes retrouvées étaient principalement artérielles avec une baisse de PSVpi<25 cm/s.
Subject(s)
Humans , Coronary Artery Disease , Heart Disease Risk Factors , Blood Pressure , Coronary Vessels , Erectile DysfunctionABSTRACT
Studies point out that the development of social skills can interfere in the students' behavior and consequently in the environment, favoring the school climate and the acquisition of knowledge. Thus, this research aimed to identify the effects of a Social Skills Training (SST) on the school climate. 21 students from the 9th grade of Elementary School participated (11 from the Experimental group and 10 from the Control group) aged between 14 and 16 years old (MD = 14.38; SD = 1.07). The instruments used were: Inventory of Social Skills for Adolescents and the Climate Scale of the Delaware Student School. Ten sessions were held, with weekly meetings of 50 minutes. For data analysis, the following tests were used: Spearman's rô, Wilcoxon and Mann-Whitney for independent samples. There were positive correlations, from moderate to strong, between the factors of social skills and the dimensions of the climate for all participants in the intervention group. In the control group, negative and positive correlations were identified.
Estudos apontam que o desenvolvimento de habilidades sociais pode interferir no comportamento dos alunos e por consequência no ambiente, favorecendo o clima escolar e a aquisição do conhecimento. Dessa forma, esta pesquisa objetivou identificar os efeitos de um treinamento de habilidades sociais (THS) no clima escolar. Participaram 21 estudantes do nono ano do ensino fundamental (11 do grupo experimental e dez do grupo controle) com idades entre 14 e 16 anos (MD = 14,38; DP = 1,07). Os instrumentos utilizados foram: Inventário de Habilidades Sociais para Adolescentes e a Escala de Clima da Escola de Delaware-Estudante. Realizaram-se dez sessões, com encontros semanais de 50 minutos. Para análise de dados, utilizaram-se os testes rô de Spearman, Wilcoxon e Mann-Whitney para amostras independentes. Observaram-se correlações positivas de moderada a forte entre os fatores das habilidades sociais e as dimensões do clima para todos os participantes do grupo intervenção. No grupo controle, identificaram-se correlações negativas e positivas.
Los estúdios señalan que el desarrollo de habilidades sociales puede interferir em el comportamiento de los estudiantes y consecuentemente em el entorno, favoreciendo el clima escolar y la adquisición de conocimientos. Por lo tanto, esta investigación tuvo como objetivo identificar los efectos de un Entrenamiento de habilidades sociales (EHS) en el clima escolar. Participaron 21 alumnos de 9º de primaria (11 del grupo experimental y diez del grupo control) con edades comprendidas entre 14 y 16 años (DM = 14,38; DT = 1,07). Los instrumentos utilizados fueron: Inventario de Habilidades Sociales para Adolescentes y Escala de Clima de la Escuela de Delaware-Estudiantes. Se realizaron diez sesiones, con reuniones semanales de 50 minutos. Para el análisis de los datos se utilizaron las pruebas: rô de Spearman, Wilcoxon y Mann-Whitney para muestras independientes. Hubo correlaciones positivas de moderadas a fuertes entre los factores de habilidades sociales y las dimensiones del clima para todos los participantes en el grupo de intervención. Em el grupo de control se identificaron correlaciones negativas y positivas.
Subject(s)
Humans , Male , Female , Adolescent , Schools , Students , Behavior , Social Skills , Personality , Psychology, Social , Education, Primary and Secondary , Educational Status , School TeachersABSTRACT
Objective : To examine how to treat patients suffering from electromagnetic hypersensitivity (EHS) combined with multiple chemical sensitivities (MCS) with herbal medicines. Methods : The patient was diagnosed as having blood stagnation (血瘀), yang deficiency (陽虚) and spleen qi deficiency (脾気虚) based on the traditional Chinese medicine (TCM) theory. Hoyokangoto which had been applied to patients with hemiplegia for a long time in China, was prescribed with cinnamon and processed aconite root. For her persistent diarrhea, ogikenchuto was administered. Results : Headache, sense of exhaustion, insomnia, and various symptoms debasing her quality of life (QOL) were shortly decreased, which made her lead a normal life. Discussion : The administration of hoyokangoto combined with cinnamon and processed aconite root added qi (気), removed blood stagnation and accelerated blood circulation and collateral channels, implying that elimination is the first (先瀉). The administration of ogikenchuto for diarrhea (spleen qi deficiency) means that tonic is the second (後補), which improved her symptoms of EHS combined with MCS. Herbal medicines may be one of the choices for treating degraded QOL of patients with EHS and/or MCS.