Remineralizing potential of CPP-ACP in white spot lesions – A systematic review

The aim of this systematic review was to assess the long term remineralizing potential of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) only in paste form compared with fluoride varnish, and or placebo in both naturally occurring and post-orthodontic white spot lesions in vivo. Data Sources: The literature search covered the electronic databases: PubMed and Google scholar from 2005-2016. Only articles published in English were included. Randomized control trials in which CPP-ACP delivered by paste form were included. All studies which met inclusion criteria underwent two independent reviews. Study Selection: Two ninety five articles were identified from the search after excluding duplications. Abstracts of forty one articles were reviewed independently. Twenty nine articles were excluded after reading abstract. Full text articles were retrieved for fifteen relevant studies. After reviewing articles independently, three articles were excluded after full text reading. Finally twelve studies were selected based on the eligibility criteria. The remineralizing effect of CPP-ACP were compared with placebo and fluoridated toothpaste and fluoride varnish in randomized control trial. Conclusion: A high level evidence of remineralizing potential of CPP-ACP on naturally occurring white spot lesion and WSL post orthodontic treatment was found in comparison with placebo/fluoridated toothpaste and fluoride varnish without any statistically significant difference. Well-designed RCTs are, therefore, required to improve the level of evidence in this area.

Remineralisation effect of 1,500 ppm fluoride-containing toothpaste in enamel early caries lesion / 대한구강보건학회지

OBJECTIVES: We compared the effects of a 1,500 ppm fluoride-containing toothpaste and a 1,000 ppm fluoride-containing toothpaste, which were revised up to the recent revision, and evaluated their effects on the tooth surface after adding bamboo salt to the preparations. METHODS: Experimental early artificial caries specimens were subjected to one of four treatments (n=12 per treatment group): 1,500 ppm NaF, 2% bamboo salt+1,000 ppm NaF, 1,000 ppm NaF, and control treatment. The specimens were exposed to the experimental toothpaste, artificial saliva, and demineralized solution. The treated specimens were analyzed using Vickers surface hardness testing, scanning electron microscopy, and atomic force microscopy. RESULTS: The toothpaste with a high fluoride concentration (1,500 ppm NaF) showed more remineralization than did the toothpaste with a low fluoride concentration (1,000 ppm NaF). The 2% bamboo salt+1,000 ppm NaF group showed remineralization similar to the 1,500 ppm NaF group and higher surface microhardness than the 1,000 ppm NaF group. CONCLUSIONS: Toothpastes containing 1,500 ppm NaF have a higher preventive effect against dental caries than do toothpastes containing 1,000 ppm NaF. The addition of bamboo salt to fluoride-containing dentifrices improves their effectiveness in preventing dental caries.

Optimizing concentration of bioactive glass that promotes early enamel caries remineralization / 天津医药

Objective To explore the optimum concentration of bioactive glass that promotes early enamel caries remineralization. Methods Fresh bovine incisors were selected and used for enamel specimen preparation. All specimens were randomly divided into two groups:micro hardness group and fluorescence group. Both groups were further divided into 3%, 6%and 9%groups. These specimens were placed in containers with demineralization liquid at 37℃for 72 hours. Then they were treat with 3%, 6%and 9%bioactive glass solution respectively twice a day for 5 minutes each. Samples in all three groups were dipped circularly into an artificial demineralization solution and an artificial saliva solution for 15 days. The mi?crohardness of enamel surface was measured before and after demineralization and remineralization. The different value of microhardness before and after remineralization was calculated. The thickness of fluorescence beneath the surface of early enamel caries was observed to evaluate the extend of remineralization effect. Results The difference in value of micro hard?ness in 6%group was the highest while that in 3%group was the lowest. The differences were significant. The difference in value of demineralization depth in 6%group was greater than those in 3%and 9%groups (P<0.05). There was no statistical?ly significance between those in 3%group and 9%group. Conclution The optimum concentration of bioactive glass solu?tion that promotes the remineralization of early enamel caries is 6%, which is ideal for remineralization of early enamel caries.