Association between early parenteral nutrition and the development of bronchopulmonary dysplasia in preterm infants / 中国当代儿科杂志

OBJECTIVES@#To study the relationship between early parenteral nutrient intake and the development of bronchopulmonary dysplasia (BPD) in preterm infants with gestational age less than 32 weeks who could not receive enteral nutrition within one week after birth.@*METHODS@#A retrospective study was conducted on preterm infants born between October 2017 and August 2022 with gestational age less than 32 weeks who were admitted to the Neonatal Intensive Care Unit in Children's Hospital of Soochow University within 24 hours after birth and relied solely on parenteral nutrition within the first week of life. The study population included 79 infants with BPD and 73 infants without BPD. Clinical data during hospitalization were compared between the two groups.@*RESULTS@#The proportions of infants with weight loss of more than 10% after birth, extrauterine growth retardation, and parenteral nutrition-associated cholestasis in the BPD group were higher than in the non-BPD group (P<0.05). The time to regain birth weight, time to achieve full enteral feeding, and corrected gestational age at discharge were longer in the BPD group than in the non-BPD group. The Z-scores of physical growth at corrected gestational age of 36 weeks were lower in the BPD group than in the non-BPD group (P<0.05). The BPD group had a higher fluid intake and a lower calories intake in the first week than the non-BPD group (P<0.05). The starting dose and total amount of amino acids, glucose, and lipids in the first week were lower in the BPD group than in the non-BPD group (P<0.05). The BPD group had a higher glucose-to-lipid ratio on the third day and higher energy-to-nitrogen and glucose-to-lipid ratios on the seventh day after birth than the non-BPD group (P<0.05).@*CONCLUSIONS@#Preterm infants with BPD had lower intake of amino acids and lipids and a lower proportion of calories provided by amino acids and lipids in the first week of life, which suggests an association between early parenteral nutrition intake and the development of BPD.

Perfil bioquímico en sangre de cordón en prematuros extremos y crecimiento fetal / Intrauterine growth and biochemical levels in cord blood samples in infants less than 31 weeks gestation

Introducción: Con mayor aporte de proteínas y energía en la primera semana se ha observado hipofosfemia en prematuros extremos. Los menores niveles de fósforo se han presentado en prematuros con antecedentes de restricción de crecimiento intrauterino. Objetivos: Caracterizar los niveles plasmáticos bioquímicos en el cordón de prematuros extremos, nacidos adecuados (AEG) y pequeños para edad gestacional (PEG) y la relación con calcemia y fosfemia en la primera semana de vida. Pacientes y método: Estudio clínico realizado en Neonatología del Hospital Doctor Sótero del Río, en los años 2013 y 2014. Se analiza el perfil bioquímico en el cordón y la calcemia y fosfemia en los primeros 7 días de vida, registrados en la ficha clínica según fueran AEG o PEG, según las curvas de Alarcón-Pittaluga. Análisis con significación de p < 0,05. Resultados: Los niveles de colesterol, transaminasas, albúmina y creatinina fueron similares para los PEG y AEG. Los niveles de pH, fósforo, calcio, y fosfatasas alcalinas fueron menores en los PEG. El nitrógeno ureico, el ácido úrico y los triglicéridos fueron mayores en los PEG. Los PEG muestran marcada reducción de fosfemia en la primera semana, la calcemia tiende a subir proporcionalmente al descenso de la fosfemia. Conclusiones: En prematuros extremos la desnutrición intrauterina se expresa en modificación de los niveles plasmáticos de calcio, fósforo, fosfatasas alcalinas, nitrógeno ureico, ácido úrico y triglicéridos. Posnatalmente, al recibir aporte nutricional, se manifiesta una disminución de la fosfemia y un aumento de calcemia, concordante con aportes insuficientes de fósforo durante el período.

Introduction: The use of greater amounts of protein and energy during the first week of life is associated with hypophosphataemia in extreme preterm babies. The lowest phosphorus levels are described in intrauterine growth restricted (IUGR) babies. Objectives: To describe biochemistry levels in cord blood plasma in extreme premature, adequate and small for gestational age babies (AGA/SGA) and their relationship with plasma calcium and phosphorus levels during the first week of life. Patients and method: A descriptive clinical study was performed in the Neonatology Service at Hospital Dr. Sótero del Río during 2013 and 2014. A biochemical analysis of cord blood was performed on 43 premature babies, as well as plasma calcium and phosphorus levels during the first week. The adequacy for gestational age was obtained using Alarcón- Pittaluga growth curves. Statistical significance was P < .05. Results: Cholesterol, transaminases, albumin and creatinine levels were similar for both AGA and SGA babies. Levels of pH, phosphorus, calcium and alkaline phosphatase were significantly lower in SGA babies. Urea nitrogen, uric acid and triglycerides levels were higher in SGA. The analysis during the first week showed a strong reduction in phosphorus levels, as well as an increase in calcium levels in proportion to the decrease in phosphorus in the SGA sub- group. Conclusions: Intrauterine malnutrition in preterm babies is expressed in the modulation of plasma levels of calcium, phosphorus, alkaline phosphatase, urea nitrogen, uric acid and triglycerides. During post-natal life, when nutritional intake begins, a decrease in phosphorus and an increase in calcium levels appear, consistent with insufficient phosphorus intake during this period.

Crecimiento, nutrición temprana y riesgo de diabetes y síndrome metabólico / Growth, early child nutrtion and risk of diabetes and metabolic syndrome

El Síndrome Metabólico, la Diabetes tipo 1 (DM1) y Diabetes tipo 2 (DM2) son condiciones con tendencia a incrementar su incidencia en la población pediátrica, constituyéndose en las enfermedades crónicas más comunes en la niñez. Los estudios sobre epigenética permiten comprender la influencia del medio sobre la expresión de susceptibilidad a enfermedad crónica. La DM1 es una condición autoinmune, y existe evidencia de que esta autoinmunidad puede ser inducida tan temprano como en el primer trimestre de vida, factores nutricionales han sido involucrados como moduladores de esta autoinmunidad. La DM2 tiene estrecha relación con el desarrollo de Obesidad y Síndrome Metabólico, se ha relacionado con malnutrición in útero, ganancia de peso precoz y rápida en niños con bajo peso al nacer, rebote adiposo temprano y dietas hipercalóricas. Se ha otorgado un papel protector a la lactancia materna sobre el desarrollo tanto de DM1 como de DM2, así como la exposición temprana a proteínas complejas dietéticas, como las de la leche entera de vaca, constituyen factores de riesgo. Se recomienda la pesquisa de DM2 en niños mayores de 5 años con sobrepeso y otros factores de riesgo, así como promover el buen estado de salud durante la gestación y la niñez mediante una dieta adecuada y ejercicio, apoyando la lactancia materna.

The Metabolic Syndrome, type 1 diabetes (DM1) and type 2 diabetes (DM2) are conditions that tend to increase their incidence in the pediatric population, becoming the most common chronic diseases in childhood. Epigenetic studies allow us to understand the influence of environment on the expression of susceptibility to chronic disease. DM1 is an autoimmune condition, and there is evidence that this autoimmunity can be induced as early as the first quarter of life, nutritional factors have been implicated as modulators of this autoimmunity. DM2, in close connection with the development of obesity and metabolic syndrome has been associated with malnutrition in utero, early and rapid gain weight in children with low birth weight, early adiposity rebound and high-calorie diets. Has been granted a protective role of breastfeeding on the development of both DM1 and DM2, and early exposure to complex dietary proteins, such as those of whole cow's milk, are risk factors. The screening of DM2 in children older than 5 years with overweight and other risk factors is recommended, as well as promoting good health during pregnancy and childhood through proper diet and exercise, supporting breastfeeding.

Extrauterine growth restriction and early nutrition support of infants with respiratory distress syndrome / 中国小儿急救医学

Objective To assess the incidences of intrauterine growth restriction (IUGR) and extrauterine growth restriction(EUGR) in premature infants with respiratory distress syndrome (RDS) and early nutritional efficiency on EUGR.Methods Data of 70 infants with RDS admitted in neonatal intensive care unit were reviewed.According to the weight when a premature infant was discharged,all subjects were divided into EUGR group(48 cases) and non-EUGR group(22 cases).The difference of two groups in terms of basic situation,peripartum factors,nutritional support,treatment measures and complications were compared.Results Assessing by weight,the incidence of IUGR and EUGR was 12.86％ (9/70)and 60.00％ (42/70)respectively.The differences in birth weight [(1 666.10 ±440.16) g vs (2 108.20 ±552.81) g],head circumference at birth [(28.81 ± 2.65) cm vs (30.48 ± 2.39) cm],IUGR,multiple pregnancy (16 cases vs 3 cases),cesarean delivery (29 cases vs 7 cases) were considered statistically significant (P ＜ 0.05),and there were no stastitically significant difference in gestational age,nutritional support,mechanical ventilation and complications (P ＞ 0.05).Conclusion The EUGR is related with IUGR,multiple pregnancy,cesarean delivery,low birthweight,low birth head circumference.The short time nutrition interventions can't improve EUGR in RDS.

Building human capacity through early childhood intervention: the Child Development Research programme at the Tropical Medicine Research Institute, The University of the West Indies, Kingston, Jamaica / Construcción de la capacidad humana mediante intervención en la primera infancia: Programa de Investigación del Desarrollo Infantil en el Instituto de Investigación de Medicina Tropical, Universidad de West Indies, Kingston, Jamaica

Research conducted by the Child Development Research Group in the Tropical Medicine Research Institute has made significant contributions to the understanding of the importance of early nutrition and the home environment for children's development and the impact of psychosocial stimulation for disadvantaged and/or undernourished children. The work has provided critical evidence that has contributed to the increasing attention given to early childhood development in the work and policies of agencies such as the World Bank, World Health Organization (WHO) and United Nations Children Fund (UNICEF). This review concerns research which documented the impact of malnutrition on children's development and for the first time demonstrated the benefits and necessity of psychosocial stimulation for improvement in development. Subsequent research was critical in establishing the importance of linear growth retardation (stunting) as a risk factor for poor child development. A twenty-two-year study of stunted children has demonstrated benefits through to adulthood in areas such as educational attainment, mental health and reduced violent behaviour, from an early childhood home visiting programme that works through mothers to promote their children's development. The group's research has also demonstrated that it is feasible and effective to integrate the stimulation intervention into primary care services with benefits to children's development and mothers' child rearing knowledge and practices. The group is currently conducting a study to provide information needed for scaling-up of parenting programmes through evaluation of a new approach to improving parenting through health centres and a modified home visit programme.

Una investigación dirigida por el Grupo de Investigación del Desarrollo Infantil en el Instituto de Investigación de Medicina Tropical, ha contribuido de manera significativa a comprender, por una parte, la importancia que tanto la nutrición temprana como el ambiente hogareño poseen para el desarrollo infantil de niños, y por otra parte, el impacto de la estimulación psicosocial para los niños desfavorecidos y/o desnutridos. La evidencia crítica ofrecida por este trabajo ha hecho que se le conceda mayor atención al desarrollo de la primera infancia en el trabajo y las políticas de agencias como el Banco Mundial, la Organización Mundial de la Salud (OMS) y el Fondo de las Naciones Unidas para la Infancia (UNICEF). Este estudio trata de una investigación que documenta el impacto de la desnutrición en el desarrollo de niños, y por primera vez demuestra los beneficios y la necesidad de la estimulación psicosocial para favorecer el desarrollo. La investigación subsiguiente fue decisiva para establecer la importancia del retraso del crecimiento linear (RCL) como un factor de riesgo para el desarrollo del niño pobre. Un estudio de veintidós años sobre niños con retraso en el crecimiento ha demostrado los beneficios hasta llegar a la adultez, en áreas como la educación, la salud mental y la reducción del comportamiento violento, a partir de un programa de visita a hogares de la primera infancia, que trabaja con las madres para promover el desarrollo de sus hijos.

Progress in the programming effect of early nutrition on hepatic lipid metabolism / 国际儿科学杂志

The early life of nutrition is closely related to obesity and metabolic syndrome in adult.Lipid metabolic dysfunction is one of the important mechanisms in the development of adult diseases.Liver plays a key role in lipid metabolism.Hepatic lipid metabolism mainly includes fatty acid uptake,synthesis,esterification,oxidation and export.Exposed to a optimal nutrition environment in early life might lead to some adaptive effects in the liver and its organization structure,cell numbers and metabolic function.These adaptive responses might play a persistent effect in each way of hepatic lipid metabolism.Clarifying the programming effect of early nutrition on hepatic lipid metabolism and the relative molecular mechanism might provide related theoretical basis and practical molecular target for the prevention of adult diseases during childhood.

Early nutritional programming and later obesity / 国际儿科学杂志

Epidemiological studies indicate that obesity is associated with metabolic disorders, such as type 2 diabetes hyperlipidemia and hypertension. Early nutrition, especially during pregnancy and lactation can lead to the permanent programming of system by some adaptive effects in physiological, cellular and molecular levels. These adaptive effects persistently changed the metabolic throughout life, hence resulted in increased risk of obesity and metabolic related disease.This review focuses upon the influence of nutrition in early life on adulthood obesity and researches on their pathophysiological mechanism .