Comparative study of the effectiveness of the surgical technique with and without preservation of the conchal cartilage in otoplasty through the measure of the cephalo-auricular and scapho-conchal angles

Abstract Objectives Prominent ear abnormalities affect 5% of the population. A prospective, double-blind study of patients who underwent otoplasty procedures to correct these abnormalities was conducted to compare two surgical techniques. They diverge by the preservation or not of conchal cartilage. Methods The two techniques were compared by measuring the cephalo-auricular and scapho-conchal angles. Measurements were performed in pre and 6-months post-operative periods using alginate molding. Twenty patients were randomly assigned to two groups (with and without cartilage preservation) with 10 participants each. Student's t-test, Covariance Analysis Model (ANCOVA), and non-parametric Mann-Whitney were used in the statistical analyses. Results A significant reduction in the average of the cephalo-auricular and scapho-conchal angles was observed in both surgical procedures (p < 0.001). However, no significant difference was found between them (p = 0.887). Conclusion The two techniques analyzed in this study fulfilled their objectives. Therefore, further comparative studies are needed to confirm the superiority of one over the other. Level I Evidence obtained from at least one properly designed randomized controlled trial.

Comparative transcriptome analysis of differential expression in different tissues of Prunella vulgaris / 中草药

Objective: To compare and analyze the transcriptome of ears, leaves and stems of Prunella vulgaris, and excavate the key enzyme genes related to the secondary metabolism biosynthesis of P. vulgaris. Methods: The transcriptome of ears, leaves and stems of P. vulgaris were sequenced by Illumina high-throughput sequencing technology. Additionally biosynthesis related enzyme gene of secondary metabolism were identified from differentially expressed genes. Results: In the transcripts of three different tissues of P. vulgaris, a total of 8 270 Unigenes differed significantly between at least two tissues. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of genes differentially expressed in different tissues showed that the expression of phenylpropanoid biosynthesis genes varied greatly. A total of 31 triterpenoid biosynthesis-related Unigenes, 16 phenolic acid biosynthesis-related Unigenes, and 113 P450s-related Unigenes were identified in the differentially expressed genes. Conclusion: This study provides a basis for the subsequent discovery of functional genes related to the secondary metabolism synthesis pathway of P. vulgaris, and plays a foundation for the regulation of secondary metabolism biosynthesis of P. vulgaris.

A small supernumerary marker chromosome resulting in mosaic partial tetrasomy 4q26-q31.21 in a foetus with multiple congenital malformations

A parental diagnosis was performed for an unborn foetus of a healthy couple, who was due for ultrasound detection of multiple malformations and abnormal amniotic fluid karyotypes. For an accurate diagnosis, routine G-banding analysis and nextgeneration sequencing (NGS)were carried out. Finally, conventional cytogenetic analysis suggested that the foetus had a karyotype of47,XX,+mar[52]/46,XN,meanwhileNGSalso revealed a partial tetrasomy of 27.84Mbfrom4q26-q31.21 (117,385,735–145,225,759), and G-banding analysis excluded the couple to have carried the 4q26-q31.21 duplication. We have identified a de novo mosaic small supernumerary marker chromosomes (sSMC) derived from 4q26-q31.21 in a foetus with hemivertebra, polydactyly, abnormal ears, and heart and ventricular septal defect.

Example of checking heart defect children through the diagnosis of ears blood vessels in traditional medicine / Шинэ санаа Шинэ нээлт

Background@#Antibrachium in a child is short, the skin of a child cannot form a thin strip, therefore it is not specifically studied by Tson, Gan, Chag, as adults. According to sources, children under the age of 8 with an index finger and an extension or vein vein in the back of the ears are closely monitored, and the diagnosis of the disease determines the grade of the disease to predict.</br> Cardiac birth defects occur at 10% of all congenital disorders. In Europe, 0.8-1.0% of infants and 0.7-1.0% of children in Russia are found to have heart failure. In our country, 1.56% or 1000 children - 15.5 have reported heart defects. In the early detection of cardiac defects, the ear diagnostic method is of great importance if diagnostics are not available.@*Purpose@#The birth of a child is diagnosed by diagnosing cardiovascular diseases using traditional medicine.@*Methods@#The main materials of the study consisted in translating the book friar Choijamz “The healing beauty of various medical books” and translating 10 books from Tibetan into Mongolian and explaining the importance of diagnosing traditional diseases in order to find correlations.</br> Using a descriptive descriptive survey design, 150 children’s ear conch were randomly selected from 2-month-olds to 2-year-olds.@*Results@#In total, 150 children took part in our survey. Of these, 74 children and 66 girls took part. Children aged 2 months and 2 years were surveyed.</br> Cardiovascular changes were made to 55 children out of 75 children with heart disease and a clinical diagnosis. The color change of the fever in red, pink and red is 45.4%. 54.6% color change in cold-blooded chronic brown-white lesions.@*Conclusions@#The earliest diagnosis of hearing in children was written in the eighth century by the old Yutogendongombo “New Moon of the World” and in the 8th century Garmarawjar novels “Compound medicine in important resume of the heart”, also among the monks Deumar Danzanpuntsag, Gomangonchogdeleg investigated the diagnosis of ear, XV and XVI century.</br> 15% of cardiovascular disorders and 85.6% of the healthy group showed no changes in the ear, and the vein was fuzzy. 85% of cardiovascular disorders and 14.4% of the healthy group were clearly visible divergent blood vessels.

Pinna synthetic mold for otoplasty techniques application / Molde sintético auricular para aplicação de técnicas de otoplastia

Abstract Introduction The ear deformity Tanzer type V, also known as prominent ears, is the most common genetic defect of the pinna. The surgery designed for its correction is known as otoplasty. This esthetic surgery can be performed using different techniques, which requires great skill of its operator. Objective The purpose of this work is the development of a new tool for otoplasty techniques training, aimed on the possibility to minimize errors during the otoplasty. Methods Synthetic molds of the external ear from patients with Tanzer type V deformity were made, using silicone material and rayon. Results The main procedures of otoplasty could be performed in the molds made of silicone and rayon with a good esthetic result. Conclusion The elaborated molds had identical size and shape of a human ear and could be positioned in the same shape of the patient ears. Thus, the synthetic molds were presented as promising simulation tools for the training and surgical enhancement of otoplasty, especially for doctors beginners.

Resumo Introdução A deformidade da orelha tipo V de Tanzer, também conhecida como orelhas proeminentes, é o defeito genético mais comum da aurícula. A cirurgia criada para sua correção é conhecida como otoplastia. Essa cirurgia estética pode ser feita com diferentes técnicas, o que requer grande habilidade de seu operador. Objetivo O objetivo desse trabalho é o desenvolvimento de uma nova ferramenta para o treinamento de técnicas de otoplastia, com o objetivo de minimizar erros durante a otoplastia. Método Foram feitos moldes sintéticos da orelha externa de pacientes com deformidade tipo V de Tanzer com material de silicone e rayon. Resultados Os principais procedimentos de otoplastia foram feitos nos moldes de silicone e rayon com um bom resultado estético. Conclusão Os moldes elaborados tinham tamanho e forma idênticos aos de uma orelha humana e puderam ser posicionados no mesmo formato das orelhas dos pacientes. Assim, os moldes sintéticos foram apresentados como ferramentas de simulação promissoras para o treinamento e aperfeiçoamento cirúrgico da otoplastia, especialmente para médicos iniciantes.

Refined Converse otoplasty with Ω shape for prominent ears / 中华整形外科杂志

Objective@#To investigate the feasibility and efficiency of refined Converse otoplasty with Ω shape for correcting prominent ears.@*Methods@#Refined Converse otoplasty with Ω shape was performed in 8 cases(3 cases of bilateral deformities)of prominent ears during January 2014 to September 2016. The postauricular fascial-perichondrial complex tissues were elevated through postauricular incision based on Converse otoplasty. The new antihelix was reformed by parallel mattress sutures though postauricular parallel cartilaginous incisions. The Ω shape appeared on the transverse section of the auricular cartilage after fascial-perichondrial sutures.@*Results@#Postoperative 6 month to one year follow-up presented satisfactory results in all 8 cases. The appropriate location and contour of the recreated antihelix was achieved. The included angle between fossae helicis and concha was decreased. The auricles were symmetric in both unilateral and bilateral patients of prominent ears. The scars were inconspicuous. Hematoma, infection, suture extrusion and secondary deformities were not seen in our series.@*Conclusions@#Natural and clear contour of the recreated antihelix was achieved by refined Converse otoplasty with Ω shape. Reoccurrence was not seen and complications were rare.

Tinnitus caused by heart disease and healed from heart / 中国针灸

Tinnitus is recognized as a refractory disease, which is common in clinic, and always treated from the liver and kidney. We treat tinnitus mainly by heart based on syndrome differentiation. It often works well when the leftpulse is abnormal. Referring to ancient literature, we find that the heart is related to ears by meridians, and the kidney and heart govern ears. The normal function of heart and kidney means normal hearing. The heart secretes atrial natriuretic polypeptins (ANP), whose receptor is widely distributed in ears and can increase the cochlear blood flow. In this paper we explore the relationship between the heart and the ears so as to provide theories of treatment by heart for tinnitus.

Síndrome de Münchausen por poder en otorrinolaringología / Münchausen syndrome by proxy in otorhinolaryngology

El síndrome de Münchausen por poder es una forma de maltrato infantil, con graves consecuencias para el niño afectado. El diagnóstico de esta afección constituye un desafío para los médicos por su heterogeneidad en los síntomas y signos de presentación. Variadas manifestaciones otorrinolaringológicas están descritas en esta patología. En este artículo se presenta un caso clínico de otitis media crónica con otorragia en un paciente de 2 años, donde se logró establecer el diagnóstico de síndrome de Münchausen por poder a través de la identificación de elementos incongruentes en la historia clínica y finalmente por la detección in fraganti de la agresión por parte de la madre. En esta revisión se concluye que es necesario un alto índice de sospecha para identificar esta patología, la que debe ser una preocupación habitual del equipo de salud para evitar asi consecuencias graves en estos pacientes, tales como secuelas psiquiátricas o incluso la muerte.

Münchausen's syndrome by proxy is a form of child abuse with severe consequences for the affected child. The diagnosis of this condition is a challenge for physicians due to the heterogeneity of the presentation symptoms. A lot of otorhinolaryngological manifestations have been described in this syndrome. We present a case of a 2 year old patient with chronic otitis media and otorrhagia, where we could establish the diagnosis of Münchausen's syndrome by proxy through the identifications of incongruent elements on the clinical history and finally the direct visualization of mother's aggression. In this should be a common concern for health workers to avoid severe consequences in these patients like psychiatric diseases or even death.

Correction of Prominent Ears / 대한이비인후과학회지

External ear anomaly was not uncommon disease. The spectrum of anomaly is wide, from mild anomalies including prominent ears, cryptotia to absence of external ear. In western countries, prominent ears were common and surgical correction was usually performed in their childhood period. However in Asian countries, including Korea, prominent ears were not considered correcting condition. Many techniques and skills were introduced to perform otoplasty since 19th century. For improving surgical result of otoplasty, operator should choose suitable surgical techniques considering patient's condition in these techniques and can read demands of patients.

The effects of 5-fluorouracil on hypertrophic scar of rabbit ears / 重庆医学

Objective To investigate the effect of 5‐fluorouracil on hypertrophic scar in rabbit ears .Methods The hyper‐trophic scar models in rabbit ears were reproduced and randomly divided into 3 groups (group A ,group B and group C) .On postop‐erative 60th days ,Hematoxylin‐eosin and Masson staining staining was applied to observe themorphological and collagen change of scars under light microscope .Real‐time PCR and ELISA were conducted to detect the expression of TGF‐β,PDGF ,bFGF and INF‐γ .Results HE and Masson staining showed that thinner dermis ,fewer fibroblasts and collagen fibers ,collagen fibers arranged reg‐ularly and less collagen nodule was observed group B compared with the group A and group C .Furthermore ,we found that TGF‐β, PDGF ,bFGF ,INF‐γmRNA and protein expression levels were significantly lower in group B and group C than the group A ,and group B was more effective than group C .Conclusion 5‐fluorouracil is effective for the treatment of hypertrophic scars ,and the lo‐calized injection of 5‐fluorouracil is more effective than the ointment group .

A Comparative Study of Performances on the Open -set Monosyllable Test of Typical Children and Hearing Impaired Children at Age 3 / 听力学及言语疾病杂志

Objective The present study analyzed the performances of hearing impaired children and normal hearing children at age 3 on the open set monosyllables test to provide reference for rehabilitation .Methods 30 typi-cal children and hearing impaired children at age 3 were randomly selected and tested using the open -set monosylla-ble test in evaluation of auditory response to speech (EARS) .Results ① There were significantly differences be-tween different test items in both groups ,the decreasing order of the score was tone> vowel>consonant>word(P<0 .01) ,and the scores on vowels ,consonants and words of hearing -impaired children were respectively signifi-cantly lower than that in normal hearing children(P<0 .001) .②There were similarities and differences between the mistakes of typical children and hearing impaired children .Blade-palatals and laterals in both groups achieved the lowest accuracy .While the accuracies on bilabials ,labiodentals ,nasals and plosives were highest in typical children , the accuracy on velar was highest in hearing impaired children .And the accuracies of consonants and nasal vowels on each place and manner of articulation in hearing -impaired children were significantly lower .Conclusion The study showed that the performances on vowels ,consomants and words of hearing -impaired children aged 3 in the open set monosyllables test were poorer than that in normal hearing children .The main errors were between the same places or methods of articulation ,especially for Blade -palatals and laterals .It is possible related to the deficiency of lan-guage input with the hearing impairment and the age with HA/CI .

Corpo estranho em meato acústico externo: avaliação de 462 casos / Foreign-body in external auditory meatus: evaluation of 462 cases

Introdução: Desde 1950, foram realizados inúmeros estudos dos corpos estranhos em orelhas e vias aéreas superiores. São casos frequentes no pronto socorro e que, se não abordados adequadamente, podem acarretar várias complicações como trauma e perfuração de membrana timpânica, hemorragias de conduto, perda auditiva e otites. Objetivo: Determinar a idade, sexo, complicações e tipo de corpos estranhos em meato acústico externo de 462 pacientes atendidos em um hospital terciário. Método: Estudo retrospectivo dos casos de corpos estranhos de orelha removidos pelo serviço de Otorrinolaringologia de um hospital terciário no período de 1º de janeiro de 1999 a 31 de julho de 2006. Resultados: Os corpos estranhos mais encontrados foram os insetos. A maior incidência de corpo estranho em orelha foi encontrada na faixa etária acima dos 16 anos e no sexo masculino. As complicações ocorreram principalmente na faixa etária abaixo dos 6 anos. Conclusão: A prevalência de corpo estranho em orelha nos adultos é elevada. As complicações ocorrem principalmente na faixa etária de 0 a 6 anos. Em nosso serviço, os insetos são os mais frequentes e os responsáveis pela maior parte das complicações.

Introduction: Since 1950, a numberless of studies of the foreign-bodies in ears and upper airways were executed. They are usual cases in the emergency rooms and, if they are not rightly addressed, they can bring about several complications as trauma and tympanic membrane perforation, auditory meatus hemorrhagia, hearing loss and otitis. Objective: Establish the age, sex, complications and foreign-bodies' type in external auditory meatus of 462 patients attended in a tertiary hospital. Method: A retrospective study of the cases of ear' foreign-bodies removed by the otorhinolaryngology service of a tertiary hospital in the period of January 1, 1999 to July 31, 2006. Results: The insects were the foreign-bodies more found. The major incidence of foreign-body in an ear was found in the age group above 16 years old and, in the male sex. The complications occurred mostly in the age group below 6 years old. Conclusion: The foreign-body' prevalence in an ear of the adults is high. The complications occur mostly in 0 to 6 years old age group. In our service, the insects are the most frequents and the responsible for the major part of the complications.

Comparison of auditory brainstem responses to speech from bilateral ears with ipsilateral recordings / 临床耳鼻咽喉头颈外科杂志

Objective:To compare the time domain and the frequency domain of speech-evoked auditory brainstem response measured by stimulation of left and right ears, and to explore the difference and possible reasons of neural coding for speech from different ears in auditory brainstem.Method:Speech-ABRs to syllable /da/ of 31 healthy adults were recorded. Statistical analysis was performed on time-domain parameters, such as latencies and amplitudes of featured peaks, and frequency-domain ones, such as amplitudes of the fundamental frequency and the first formant of speech-ABRs ranging from 20-50 ms. A scoring criterion to grade the appearance of featured waves was proposed for waveform evaluation.Result:There were no significant difference for the latencies of binaural featured peaks and amplitudes of feature peaks(except peaks A and O). The waveform scores of right ear were greater than that of left ear. The amplitudes of fundamental frequency of binaural waves were both greater than that of the first formant. There was no significant difference of amplitudes of fundamental frequency and the first formant between two ears.Conclusion:The origins and distributions of speech-ABR are essentially symmetrical in brainstem in contrast with the hemisphere asymmetry of speech.

Desempenho de híbridos experimentais e comerciais de milho para produção de milho verde / Performance of experimental and commercial hybrids of maize for the production of green maize

Conduziu-se este trabalho com objetivo de avaliar o desempenho de 32 híbridos experimentais e 4 híbridos comerciais para produção de milho verde em Lavras, MG. O delineamento utilizado foi de blocos ao acaso com duas repetições. Foram avaliadas sete características de interesse agronômico e comercial para a produção de milho verde. Os dados obtidos foram submetidos à análise de variância, decompondo o efeito dos híbridos em híbridos comerciais, híbridos experimentais e híbridos comerciais versus híbridos experimentais. Foram feitos ainda estudos de correlação entre as diferentes características agronômicas dos híbridos. Entre os híbridos avaliados há híbridos experimentais promissores com desempenho superior a híbridos comerciais amplamente utilizados no Brasil. Considerando as características avaliadas, os híbridos AG 1051, AG 4051, GNS 03, GNS 21, GNS 23 e GNS 35 foram os mais promissores. É possível reduzir o número de características avaliadas em experimentos com milho verde, uma vez que existem associações entre as principais características avaliadas para essa finalidade. A produtividade de espigas empalhadas e despalhadas e a cor dos grãos são características imprescindíveis nessa avaliação.

The objective of this research was to evaluate the performance of thirty-two experimental hybrids and four commercial hybrids of green maize at Lavras, MG. The experimental design was a randomized blocks with two replications. Seven characteristics of agronomic and commercial interest for the production of green maize had been evaluated. For each experiment, the data obtained were submitted to the analysis of variance decomposing the effect of the hybrids in commercial hybrids versus experimental hybrids. There were still made studies of correlation among the different characteristics. Among all of evaluated hybrids, there are experimental promising hybrids with performance superior to the commercial hybrids widely utilized in Brazil. Taking into account all the characteristics evaluated, hybrids AG 1051, AG 4051, GNS 03, GNS 21, GNS 23 and GNS 35 were the most promising. It is possible to reduce the number of characteristics evaluated as green maize, since there are high associations among the main characteristics evaluated for this purpose. The yield of strawed ears along and the color of the grains are indispensable characteristics in that evaluation.

A Case-control Study on High-risk Factors for Newborn Hearing Loss in Seven Cities of Shandong Province / 华中科技大学学报（医学）（英德文版）

To investigate the high-risk factors for newborn heating loss and to provide information for preventing the development of hearing loss and delaying its progression, from May 2003 to June 2006, neonates who failed to pass the universal newborn hearing screening (UNHS) were referred to Jinan Newborn Hearing Screening and Rehabilitation Center from 7 newborn heating screening centers in seven cities of Shandong province. One-to-one pair-matched case-control method was employed for statistical analysis of the basic features of definitely identified cases. High-risk factors relating to the bilateral hearing loss were evaluated by univariate and multivariate Logistic regression analysis. Our results revealed that 721 transferred newborns who didn't pass the heating screening received audiological and medical evaluation and 367 were confirmed to have heating loss. Of them,177 neonates with heating loss who met the matching requirements were included in the study as subjects. Univariate analysis showed that high-risk factors related to hearing loss incuded age of father, education backgrounds of parents, parity, birth weight, gestational weeks, craniofacial deformity,history of receiving treatment in neonatal intensive care unit (NICU), neonatal disease, family history of otopathy and family history of congenital hearing loss. Multivariate Logistic regression analysis revealed that 4 independent risk factors were related to bilateral hearing loss, including parity (OR=16.285, 95% CI 3.379-78.481), neonatal disease (OR=34.968, 95% CI 2.720-449.534),family history of congenital hearing loss (OR=69.488, 95% CI 4.417-1093.300) and birth weight (OR=0.241, 95% CI 0.090-0.648). It is concluded that parity, neonatal disease and family history of hearing loss are the promoting factors of bilateral hearing loss in neonates and appropriate intervention measures should be taken to deal with the risk factors.

Cartilage-Perichondrium Tympanoplasty for Pediatric Atelectatic Ears / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Pediatric atlectasis of the pars tensa occurs fairly commonly in patients with previous ear disease, especially otitis media with effusion. The atelectatic ears have been classified into four grades. For grades 3 and 4 atlectasis, for which it is difficult to manage by conservative treatment, some surgeons suggest fascia and perichondrium grafts to reinforce thin atrophic tympanic membranes. In such situations, fascia and perichondrium are often shown to undergo atrophy and subsequent failure in the postoperative period. In this study, we attempted to assess the efficacy of cartilage-perichondrium tympanoplasty for pediatric atelectatic. We used cartilage-perichondrium for graft because it was more rigid and it tended to resist resorption and retraction even in the face of continued eustachian tube dysfunction. MATERIALS AND METHOD: Twenty one patients who underwent cartilage-perichondrium tympanoplasty were assessed retrospectively. RESULTS: The atelectatic ears were elevated and everted in all patients. The air-bone gap was less than 10 dB in 57%, and less than 20 dB in 33% of the patients observed. The postoperative CT showed a well placed graft with good ventilated middle ear cavity and mastoid cavity. CONCLUSION: It can be suggested from this study that the cartilage-perichondrium tympanoplasty offers the possibility of rigorous drum reconstruction with excellent postoperative hearing results.

A Case of Juvenile Spring Eruption of the Ears

Juvenile spring eruption(JSE) of the ears is an unusual type of photodermatosis, which develops on the light exposed areas of the ears of boys and young male adults in the early spring months. JSE has received little attention in the literature, and to our knowledge no cases have been reported in Korea until now. Herein we report a case of JSE occurring in a 17-year-old man who has suffered from a recurrent pruritic erythematous papulovesicular eruption of both helix, followed by crusting and healing without scarring within one to two months early each spring for six years.