ABSTRACT
Eccrine angiomatous hamartoma (EAH) is a benign, uncommon, combined vascular and eccrine malformation. Most cases of this disorder have been single or multiple nodules or plaques that appear red, yellow, blue, violaceous, or skin colored. EAH may be congenital or appear later in childhood; it rarely arises during puberty or adulthood. A 52-year-old female patient visited our department for tender subcutaneous cystic tumor on the right sole with a one month history. Histopathologic examination confirmed EAH. During excisional biopsy procedure, mucinous discharges were observed which were histopathologically diagnosed as ganglion.
Subject(s)
Female , Humans , Middle Aged , Biopsy , Foot , Ganglion Cysts , Hamartoma , Mucins , Puberty , SkinABSTRACT
Eccrine angiomatous hamartomas are benign vascular and eccrine malformations often accompanied by hyperhidrosis or pain, increased eccrine glands, and aggregates of vessels. Verrucous hemangiomas are congenital vascular malformations presenting as unilateral grouped papules. Histologically, they show verrucous epidermal change and proliferation of capillaries in the dermis. We report a case of a 47-year-old woman with a red keratotic patch overlying a bluish plaque on the right sole, which had been present since birth. It was accompanied by pain and hyperhidrosis. Histologically, there were verrucous changes in the epidermis, numerous dilated capillaries in the papillary dermis, and increased eccrine glands with angiomatous foci in the deep dermis. The epithelial cells of the eccrine glands were positive for CEA, and the endothelial cells were positive for CD31 and GLUT-1. Eccrine angiomatous hamartomas have been reported in conjunction with other vascular tumors in only a few instances. We report an interesting case of an eccrine angiomatous hamartoma associated with a verrucous hemangioma.
Subject(s)
Female , Humans , Middle Aged , Capillaries , Dermis , Eccrine Glands , Endothelial Cells , Epidermis , Epithelial Cells , Hamartoma , Hemangioma , Hyperhidrosis , Parturition , Vascular MalformationsABSTRACT
Eccrine angiomatous hamartoma (EAH) is a benign, uncommon cutaneous lesion, often localized to the distal extremities of children. It usually presents as a solitary, asymptomatic lesion that appears as a nodule or plaque, but sometimes it can occur as multiple lesions. Varying degrees of hyperhidrosis and pain have been reported. The histological feature is characterized by a proliferation of eccrine sweat glands and angiomatous channels. Occasionally, other elements are involved, such as mucin-secreting cells, adipose tissue, bony structures, apocrine glands or hair structures. We describe a case of eccrine angiomatous hamartoma with unusual lipomatous involvement.
Subject(s)
Child , Humans , Adipose Tissue , Apocrine Glands , Extremities , Hair , Hamartoma , Hyperhidrosis , Sweat GlandsABSTRACT
Eccrine angiomatous hamartoma (EAH) is a rare, benign lesion characterized by an abnormal dermal proliferation of eccrine glands and vascular channels. It generally presents as a single asymptomatic nodule or plaque associated with pain or hyperhidrosis. It may be congenital or appear later in childhood. Thus far, there is only one case report of EAH arising in a American patient with known Neurofibromatosis type-1 (NF-1). We describe a second case of EAH in NF-1 patient and suggest some possibilities for the association of EAH with NF.
Subject(s)
Humans , Eccrine Glands , Hamartoma , Hyperhidrosis , NeurofibromatosesABSTRACT
Eccrine angiomatous hamartoma is a rare benign tumor similar to hemangioma in appearance. Unlike hemangioma, it has numerous eccrine structures in addition to numerous capillary channels. Occasionally it accompanies hyperhidrosis and pain. The sweat apparatuses in the lesions showed antigenic activities by immunohistochemical stains, particularly with anti-S100 protein and anti-CEA, the two common antigens associated with eccrine sweat glands. The antigenic activities of anti-S100 protein and anti-CEA in sweat gland structure of 2 presenting cases, one with sweating and the other without sweating, were compared to each other. As a result, we found no differences between the two cases. Although an aggressive treatment is not required due to its benign nature, total excision can be considered in cases with severe symptoms. We present two cases of eccrine angiomatous hamartoma developed on right knee joint areas in a 2-year-old male and a 10 month-old male, respectively.